{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:22:56Z","timestamp":1792581776310,"version":"4.5.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI44259"],"award-info":[{"award-number":["AI44259"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI68731"],"award-info":[{"award-number":["AI68731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR56113"],"award-info":[{"award-number":["AR56113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR55695"],"award-info":[{"award-number":["AR55695"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Howard Hughes Institute","award":["CA009537"],"award-info":[{"award-number":["CA009537"]}]},{"name":"Howard Hughes Institute","award":["T32-GM007270"],"award-info":[{"award-number":["T32-GM007270"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thymic stromal lymphopoietin (TSLP) is an IL-7\u2013related cytokine, produced by epithelial cells, that has been linked to atopic dermatitis and asthma; however, it remains unclear how TSLP shapes the adaptive immune response that causes these allergic disorders. In this study, we demonstrate a role for TSLP in a Th2 model of contact hypersensitivity in mice. TSLP is required for the development of Th2-type contact hypersensitivity induced by the hapten FITC in combination with the sensitizing agent dibutyl phthalate. TSLPR-deficient mice exhibited a dramatically reduced response, including markedly reduced local infiltration by eosinophils, Th2 cytokine production, and serum IgE levels, following FITC sensitization and challenge. The reduced response by TSLPR-deficient mice is likely due to decreased frequency and reduced T cell stimulatory function of skin-derived Ag-bearing FITC+CD11c+ dendritic cells in draining lymph nodes following FITC sensitization. These data suggest that skin-derived dendritic cells are direct or indirect targets of TSLP in the development of type 2 immune responses in the skin, where TSLP drives their maturation, accumulation in skin draining lymph nodes, and ability to induce proliferation of naive allergen-specific T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.0803478","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T21:41:20Z","timestamp":1266615680000},"page":"2974-2984","source":"Crossref","is-referenced-by-count":107,"title":["Dibutyl Phthalate-Induced Thymic Stromal Lymphopoietin Is Required for Th2 Contact Hypersensitivity Responses"],"prefix":"10.1093","volume":"184","author":[{"given":"Ryan P","family":"Larson","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"},{"name":"Immunology Program, Benaroya Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone C","family":"Zimmerli","sequence":"additional","affiliation":[{"name":"Laboratory of Allergy, Division of Immunology and Allergy, Geneva University Hospitals and Medical School , Geneva,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Comeau","sequence":"additional","affiliation":[{"name":"Amgen , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Itano","sequence":"additional","affiliation":[{"name":"Amgen , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Omori","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Iseki","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Hauser","sequence":"additional","affiliation":[{"name":"Laboratory of Allergy, Division of Immunology and Allergy, Geneva University Hospitals and Medical School , Geneva,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"},{"name":"Immunology Program, Benaroya Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,3,15]]},"reference":[{"key":"2026012806292050100_r1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.immunol.25.022106.141718","article-title":"TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.","volume":"25","author":"Liu","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"2026012806292050100_r2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat. Immunol."},{"key":"2026012806292050100_r3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ni1360","article-title":"Thymic stromal lymphopoietin in normal and pathogenic T cell development and function.","volume":"7","author":"Ziegler","year":"2006","journal-title":"Nat. Immunol."},{"key":"2026012806292050100_r4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.20062211","article-title":"Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells.","volume":"204","author":"Allakhverdi","year":"2007","journal-title":"J. Exp. Med."},{"key":"2026012806292050100_r5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1084\/jem.192.5.659","article-title":"Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor.","volume":"192","author":"Park","year":"2000","journal-title":"J. Exp. Med."},{"key":"2026012806292050100_r6","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.4049\/jimmunol.178.3.1396","article-title":"Induction of IL-4 expression in CD4+ T cells by thymic stromal lymphopoietin.","volume":"178","author":"Omori","year":"2007","journal-title":"J. Immunol."},{"key":"2026012806292050100_r7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/76923","article-title":"Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin.","volume":"1","author":"Pandey","year":"2000","journal-title":"Nat. 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