{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:35:57Z","timestamp":1785515757265,"version":"3.56.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T00:00:00Z","timestamp":1260748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C7056\/A2739"],"award-info":[{"award-number":["C7056\/A2739"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tapasin edits the peptide repertoire presented to CD8+ T cells by favoring loading of slow off-rate peptides on MHC I molecules. To investigate the role of tapasin on T cell immunodominance we used poxvirus viral vectors expressing a polytope of lymphocytic choriomeningitis virus epitopes with different off-rates. In tapasin-deficient mice, responses to subdominant fast off-rate peptides were clearly favored. This alteration of the CD8+ T cell hierarchy was a consequence of tapasin editing and not a consequence of the alteration of the T cell repertoire in tapasin-deficient mice, because bone marrow chimeric mice (wild-type recipients reconstituted with tapasin knockout bone marrow) showed the same hierarchy as the tapasin knockout mice. Tapasin editing is therefore a contributing factor to the phenomenon of immunodominance. Although tapasin knockout cells have low MHC I surface expression, Ag presentation was efficient and resulted in strong T cell responses involving T cells with increased functional avidity. Therefore, in this model, tapasin-deficient mice do not have a reduced but rather have an altered immune response.<\/jats:p>","DOI":"10.4049\/jimmunol.0803489","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T03:38:26Z","timestamp":1259638706000},"page":"73-83","source":"Crossref","is-referenced-by-count":19,"title":["Absence of Tapasin Alters Immunodominance against a Lymphocytic Choriomeningitis Virus Polytope"],"prefix":"10.1093","volume":"184","author":[{"given":"Denise S M","family":"Boulanger","sequence":"first","affiliation":[{"name":"Cancer Research UK Centre, Cancer Sciences Division, School of Medicine, University of Southampton, MP824, Southampton General Hospital , Southampton SO16 6YD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre, Cancer Sciences Division, School of Medicine, University of Southampton, MP824, Southampton General Hospital , Southampton SO16 6YD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ayers","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre, Cancer Sciences Division, School of Medicine, University of Southampton, MP824, Southampton General Hospital , Southampton SO16 6YD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H","family":"Prior","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre, Cancer Sciences Division, School of Medicine, University of Southampton, MP824, Southampton General Hospital , Southampton SO16 6YD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"James","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre, Cancer Sciences Division, School of Medicine, University of Southampton, MP824, Southampton General Hospital , Southampton SO16 6YD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P","family":"Williams","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre, Cancer Sciences Division, School of Medicine, University of Southampton, MP824, Southampton General Hospital , Southampton SO16 6YD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Elliott","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre, Cancer Sciences Division, School of Medicine, University of Southampton, MP824, Southampton General Hospital , Southampton SO16 6YD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,14]]},"reference":[{"key":"2025032710012359900_r1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2005.00311.x","article-title":"The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex.","volume":"207","author":"Elliott","year":"2005","journal-title":"Immunol. 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