{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:19:20Z","timestamp":1789391960800,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Listeria monocytogenes (LM) causes a life-threatening infectious disease affecting the brain of humans and domestic animals. Unfortunately, no adequate murine models for CNS listeriosis exist. Using intraparenchymal injection, we have established a new murine model for CNS listeriosis. Injection of a small volume of bacterial suspension limits the bacteria to the brain parenchyma with no leakage into the ventricular system. This new method enabled us to investigate the progression of and recovery from listerial brain infection, revealing roles for both innate and adaptive immune cells in CNS listeriosis. In the early phase of CNS listeriosis, NK cell-derived IFN-\u03b3 is a critical cytokine in the limitation of bacterial growth by the host defense. During the later phase, CD8+ but not CD4+ T cells play a critical role and LM-specific CD8+ T cells kill LM-infected microglia. Thus, innate and adaptive immune responses combine to successfully eliminate bacteria from the brain.<\/jats:p>","DOI":"10.4049\/jimmunol.0803798","type":"journal-article","created":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T16:48:20Z","timestamp":1241455700000},"page":"6360-6368","source":"Crossref","is-referenced-by-count":18,"title":["Critical Roles of NK and CD8+ T Cells in Central Nervous System Listeriosis"],"prefix":"10.1093","volume":"182","author":[{"given":"Toshiyuki","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology"},{"name":"Department of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"},{"name":"Core Research for Evolutionary Science and Technology, Japan Science and Technology Agency , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"},{"name":"Core Research for Evolutionary Science and Technology, Japan Science and Technology Agency , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Keio University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kawase","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Koyasu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"2026012806300821800_R1","first-page":"423","article-title":"Listeria monocytogenes: a multifaceted model.","volume-title":"Nat. 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