{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:57:19Z","timestamp":1790128639244,"version":"4.0.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammatory stresses associated with inflammatory bowel diseases up-regulate P2Y2 mRNA receptor expression in the human colon adenocarcinoma cell line Caco-2, the noncancerous IEC-6 cells and in colonic tissues of patient suffering from Crohn\u2019s disease and ulcerative colitis. However, the transcriptional events regulating P2Y2 receptor (P2Y2R) expression are not known. We have identified a putative transcription start site in the P2Y2R gene and demonstrated acetylation of Lys14 on histone H3 and Lys8 on histone H4, thus suggesting that the chromatin associated with the P2Y2 promoter is accessible to transcription factors. We also showed that the transcription factor NF-\u03baB p65 regulates P2Y2R transcription under both proinflammatory and basal conditions. A NF-\u03baB-responsive element was identified at \u2212181 to \u2212172 bp in the promoter region of P2Y2. Hence, activation of P2Y2R by ATP and UTP stimulated cyclooxygenase-2 expression and PGE2 secretion by intestinal epithelial cells. These findings demonstrate that P2Y2R expression is regulated during intestinal inflammation through an NF-\u03baB p65-dependent mechanism and could contribute not only to inflammatory bowel disease but also to other inflammatory diseases by regulating PG release.<\/jats:p>","DOI":"10.4049\/jimmunol.0803977","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T20:55:29Z","timestamp":1252097729000},"page":"4521-4529","source":"Crossref","is-referenced-by-count":58,"title":["<i>P2Y<\/i>\n                    <i>2<\/i>\n                    Receptor Transcription Is Increased by NF-\u03baB and Stimulates Cyclooxygenase-2 Expression and PGE2 Released by Intestinal Epithelial Cells"],"prefix":"10.1093","volume":"183","author":[{"given":"Emilie","family":"Degagn\u00e9","sequence":"first","affiliation":[{"name":"Canadian Institutes of Health Research Team on the Digestive Epithelium, D\u00e9partement d\u2019Anatomie et de Biologie Cellulaire, Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djordje M","family":"Grbic","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Team on the Digestive Epithelium, D\u00e9partement d\u2019Anatomie et de Biologie Cellulaire, Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9e-Anne","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Team on the Digestive Epithelium, D\u00e9partement d\u2019Anatomie et de Biologie Cellulaire, Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise G","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Langlois","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Team on the Digestive Epithelium, D\u00e9partement d\u2019Anatomie et de Biologie Cellulaire, Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Missouri , Columbia, MO 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A","family":"Weisman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Missouri , Columbia, MO 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"S\u00e9vigny","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernand-Pierre","family":"Gendron","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Team on the Digestive Epithelium, D\u00e9partement d\u2019Anatomie et de Biologie Cellulaire, Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"2025032620143581900_R1","first-page":"275","article-title":"Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense.","volume-title":"Br. 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