{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:25:00Z","timestamp":1791289500049,"version":"4.3.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Natural CD4+CD25+Foxp3+ regulatory T cells (Treg) effectively prevent autoimmune disease development, but their role in maintaining physiological tolerance against self-Ag of internal organs is not yet defined. In this study, we quantified disease-specific Treg (DS-Treg) as Treg that preferentially suppress one autoimmune disease over another in day 3 thymectomized recipients. A striking difference was found among individual lymph nodes (LN) of normal mice; Treg from draining LN were 15\u201350 times more efficient than those of nondraining LN at suppressing autoimmune diseases of ovary, prostate, and lacrimal glands. The difference disappeared upon auto-Ag ablation and returned upon auto-Ag re-expression. In contrast, the CD4+CD25\u2212 effector T cells from different individual LN induced multiorgan inflammation with comparable organ distribution. We propose that peripheral tolerance for internal organs relies on the control of autoreactive effector T cells by strategic enrichment of Ag-specific Treg in the regional LN.<\/jats:p>","DOI":"10.4049\/jimmunol.0804251","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T22:22:55Z","timestamp":1258582975000},"page":"7635-7638","source":"Crossref","is-referenced-by-count":51,"title":["Cutting Edge: Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune Disease-Suppressive Capacity"],"prefix":"10.1093","volume":"183","author":[{"given":"Karen M","family":"Wheeler","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Virginia , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen T","family":"Samy","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S K","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,15]]},"reference":[{"key":"2026012811214686300_R1","first-page":"1079","article-title":"Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.","volume-title":"J. 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