{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:24:07Z","timestamp":1781191447764,"version":"3.54.1"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The effect of filarial infections on malaria-specific immune responses was investigated in Malian villages coendemic for filariasis (Fil) and malaria. Cytokines were measured from plasma and Ag-stimulated whole blood from individuals with Wuchereria bancrofti and\/or Mansonella perstans infections (Fil+; n = 19) and those without evidence of filarial infection (Fil\u2212; n = 19). Plasma levels of IL-10 (geometric mean [GM], 22.8 vs 10.4) were higher in Fil+ compared with Fil\u2212, whereas levels of IFN-inducible protein (IP)-10 were lower in Fil+ (GM, 66.3 vs 110.0). Fil+ had higher levels of spontaneously secreted IL-10 (GM, 59.3 vs 6.8 pg\/ml) and lower levels of IL-2 (1.0 vs 1.2 pg\/ml) than did Fil\u2212. Although there were no differences in levels of Staphylococcus aureus enterotoxin B-induced cytokines between the two groups, Fil+ mounted lower IL-12p70 (GM, 1.11 vs 3.83 pg\/ml; p = 0.007), IFN-\u03b3 (GM, 5.44 vs 23.41 pg\/ml; p = 0.009), and IP-10 (GM, 29.43 vs 281.7 pg\/ml; p = 0.007) responses following malaria Ag (MalAg) stimulation compared with Fil\u2212. In contrast, Fil+ individuals had a higher MalAg-specific IL-10 response (GM, 7318 pg\/ml vs 3029 pg\/ml; p = 0.006) compared with those without filarial infection. Neutralizing Ab to IL-10 (but not to TGF\u03b2) reversed the down-regulated MalAg-specific IFN-\u03b3 and IP-10 (p &amp;lt; 0.001) responses in Fil+. Together, these data demonstrate that filarial infections modulate the Plasmodium falciparum-specific IL-12p70\/IFN-\u03b3 secretion pathways known to play a key role in resistance to malaria and that they do so in an IL-10-dependent manner.<\/jats:p>","DOI":"10.4049\/jimmunol.0900257","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T20:49:03Z","timestamp":1246049343000},"page":"916-924","source":"Crossref","is-referenced-by-count":56,"title":["Patent Filarial Infection Modulates Malaria-Specific Type 1 Cytokine Responses in an IL-10-Dependent Manner in a Filaria\/Malaria-Coinfected Population"],"prefix":"10.1093","volume":"183","author":[{"given":"Simon","family":"Metenou","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Demb\u00e9l\u00e9","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siaka","family":"Konate","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Housseini","family":"Dolo","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siaka Y","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaya I","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah A","family":"Diallo","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamine","family":"Soumaoro","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel E","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dramane","family":"Sanogo","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salif S","family":"Doumbia","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Wagner","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekou F","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"Filariasis Unit, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako , Bamako,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Klion","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Mahanty","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B","family":"Nutman","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 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