{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:25:58Z","timestamp":1769761558109,"version":"3.49.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-17A and IL-17F regulate granulopoiesis and are produced by memory T cells. Rag1\u2212\/\u2212 recombinase-activating gene-deficient mice cannot produce mature T cells but maintain normal neutrophil counts. Athymic nude mice are neutropenic or have near-normal neutrophil counts, depending on the prevailing intestinal flora, and do not produce IL-17A. By contrast, thymi from Rag1\u2212\/\u2212 mice contain as much IL-17A as those from wild-type (WT) mice. IL-17A-producing cells are found in the double negative DN1 compartment of the Rag1\u2212\/\u2212 thymus and express intracellular CD3. These cells colonize the spleen and mesenteric lymph node and secrete IL-17A in vitro following stimulation with IL-23 at a level similar to that of WT splenocytes. Adoptively transferred Rag1\u2212\/\u2212 or WT thymocytes correct neutrophil counts in neutropenic nude mice. We conclude that the development of IL-17A-producing T-lineage cells requires an intact thymic epithelium, but not V(D)J recombination.<\/jats:p>","DOI":"10.4049\/jimmunol.0900887","type":"journal-article","created":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T17:42:08Z","timestamp":1256060528000},"page":"5685-5693","source":"Crossref","is-referenced-by-count":11,"title":["T-Lineage Cells Require the Thymus but Not V(D)J Recombination to Produce IL-17A and Regulate Granulopoiesis In Vivo"],"prefix":"10.1093","volume":"183","author":[{"given":"Emily","family":"Smith","sequence":"first","affiliation":[{"name":"Robert M. Berne Cardiovascular Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibylle","family":"von Vietinghoff","sequence":"additional","affiliation":[{"name":"Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A","family":"Stark","sequence":"additional","affiliation":[{"name":"Robert M. Berne Cardiovascular Research Center"},{"name":"Department of Molecular Physiology and Biological Physics, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Zarbock","sequence":"additional","affiliation":[{"name":"Robert M. Berne Cardiovascular Research Center"},{"name":"Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"},{"name":"Department of Anesthesiology and Critical Care Medicine, University of M\u00fcnster , M\u00fcnster,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Sanders","sequence":"additional","affiliation":[{"name":"Robert M. Berne Cardiovascular Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Duley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Rivera-Nieves","sequence":"additional","affiliation":[{"name":"Mucosal Inflammation Program, University of Colorado Health Sciences Center , Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Ley","sequence":"additional","affiliation":[{"name":"Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"2026012811144670500_R1","first-page":"3360","article-title":"Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis.","volume-title":"J. 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