{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:22Z","timestamp":1791295342191,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The T cell response to Shigella, the causative agent of bacillary dysentery, remains poorly understood. Using a murine model of infection, we report that Shigella flexneri primes predominately IL-17A\u2013 and IL-22\u2013producing Th17 cells. Shigella-specific Th1 cells are only significantly induced on secondary infection, whereas specific Th2 and CD8+ T cells are undetectable. Apart from Th17 cells that are primed in a MHC class II- and IL-6\u2013dependent, but IL12\/23p40-independent manner, we identified \u03b3\u03b4 T cells as an additional but minor source of IL-17A. Priming of IL-17A+ \u03b3\u03b4 T cells is dependent on IL12\/23p40, but independent of MHC-class II and IL-6. Th17 cells have emerged as important players in inflammatory, autoimmune, and infectious diseases. Among the yet unresolved questions is their role in long-term immunity to pathogens. In this study, we show that the elicited S. flexneri-specific Th17 pool gives rise to an enhanced recall response up to 12 mo after priming, suggesting the presence of a long-term memory state. The clearance of primary infection is impaired in the absence of T cells, but independently of IL-17A. However, after reinfection, IL-17A produced by S. flexneri-specific Th17 cells becomes important to ultimately restrict bacterial growth. These findings bring new insights into the adaptive immune response to Shigella infection and highlight the importance of pathogen-specific Th17 cell immunity for secondary immune protection.<\/jats:p>","DOI":"10.4049\/jimmunol.0900978","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T21:55:00Z","timestamp":1264024500000},"page":"2076-2085","source":"Crossref","is-referenced-by-count":89,"title":["Th17 Cells Are the Dominant T Cell Subtype Primed by\n                    <i>Shigella flexneri<\/i>\n                    Mediating Protective Immunity"],"prefix":"10.1093","volume":"184","author":[{"given":"Gernot","family":"Sellge","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Pathog\u00e9nie Microbienne Mol\u00e9culaire"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale , U786"},{"name":"Department of Medicine III, Rheinisch-Westfalische Technische Hochschule University Hospital Aachen , Aachen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao G","family":"Magalhaes","sequence":"additional","affiliation":[{"name":"University of Toronto, Faculty of Medicine, Department of Immunology , Toronto, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Konradt","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pathog\u00e9nie Microbienne Mol\u00e9culaire"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale , U786"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg H","family":"Fritz","sequence":"additional","affiliation":[{"name":"University of Toronto, Faculty of Medicine, Department of Immunology , Toronto, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmara","family":"Salgado-Pabon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pathog\u00e9nie Microbienne Mol\u00e9culaire"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale , U786"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Eberl","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphoid Tissue Development"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Unit\u00e9 du D\u00e9veloppement des Lymphocytes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Cytokines et D\u00e9veloppement Lympho\u00efde, Institut Pasteur"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale , U668, Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillippe J","family":"Sansonetti","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pathog\u00e9nie Microbienne Mol\u00e9culaire"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale , U786"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Phalipon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pathog\u00e9nie Microbienne Mol\u00e9culaire"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale , U786"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"key":"2026012806264924600_r1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrmicro1662","article-title":"Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road.","volume":"5","author":"Levine","year":"2007","journal-title":"Nat. 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