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However, it is largely unknown if it has a role in regulating mature T cell activation and T cell-mediated immune responses. In this study, we demonstrate that, like IL-7R\u03b1 and CD62L, TCF-1 and lymphoid enhancer-binding factor 1 exhibit dynamic expression changes during T cell responses, being highly expressed in naive T cells, downregulated in effector T cells, and upregulated again in memory T cells. Enforced expression of a p45 TCF-1 isoform limited the expansion of Ag-specific CD8 T cells in response to Listeria monocytogenes infection. However, when the p45 transgene was coupled with ectopic expression of stabilized \u03b2-catenin, more Ag-specific memory CD8 T cells were generated, with enhanced ability to produce IL-2. Moreover, these memory CD8 T cells expanded to a larger number of secondary effectors and cleared bacteria faster when the immunized mice were rechallenged with virulent L. monocytogenes. Furthermore, in response to vaccinia virus or lymphocytic choriomeningitis virus infection, more Ag-specific memory CD8 T cells were generated in the presence of p45 and stabilized \u03b2-catenin transgenes. Although activated Wnt signaling also resulted in larger numbers of Ag-specific memory CD4 T cells, their functional attributes and expansion after the secondary infection were not improved. Thus, constitutive activation of the canonical Wnt pathway favors memory CD8 T cell formation during initial immunization, resulting in enhanced immunity upon second encounter with the same pathogen.<\/jats:p>","DOI":"10.4049\/jimmunol.0901199","type":"journal-article","created":{"date-parts":[[2009,12,21]],"date-time":"2009-12-21T21:36:14Z","timestamp":1261431374000},"page":"1191-1199","source":"Crossref","is-referenced-by-count":167,"title":["Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells"],"prefix":"10.1093","volume":"184","author":[{"given":"Dong-Mei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie S","family":"Haring","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Held","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne , Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Department of Pathology"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Harty","sequence":"additional","affiliation":[{"name":"Department of Microbiology"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hui","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Microbiology"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,21]]},"reference":[{"key":"2026012808085163800_r1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nri2251","article-title":"Shaping and reshaping CD8+ T-cell memory.","volume":"8","author":"Harty","year":"2008","journal-title":"Nat. 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