{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:29:49Z","timestamp":1791268189220,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Outside of the TLR paradigm, there is little understanding of how pathogen recognition at the cell surface is linked to functional responses in cells of the innate immune system. Recent work in this area demonstrates that the yeast particle zymosan, by binding to the \u03b2-glucan receptor Dectin-1, activates an ITAM-Syk\u2013dependent pathway in dendritic cells, which is required for optimal cytokine production and generation of an oxidative burst. It remains unclear how activation of Syk is coupled to effector mechanisms. In human macrophages, zymosan rapidly activated a calcium-dependent pathway downstream of Dectin-1 and Syk that led to activation of calmodulin-dependent kinase II and Pyk2. Calmodulin-dependent kinase and Pyk2 transduced calcium signals into activation of the ERK\u2013MAPK pathway, CREB, and generation of an oxidative burst, leading to downstream production of IL-10. These observations identify a new calcium-mediated signaling pathway activated by zymosan and link this pathway to both inflammatory and anti-inflammatory responses in macrophages.<\/jats:p>","DOI":"10.4049\/jimmunol.0901293","type":"journal-article","created":{"date-parts":[[2010,4,16]],"date-time":"2010-04-16T22:18:29Z","timestamp":1271456309000},"page":"5545-5552","source":"Crossref","is-referenced-by-count":87,"title":["Calcium-Activated Pathways and Oxidative Burst Mediate Zymosan-Induced Signaling and IL-10 Production in Human Macrophages"],"prefix":"10.1093","volume":"184","author":[{"given":"Erin K","family":"Kelly","sequence":"first","affiliation":[{"name":"Graduate Program in Cell Biology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Arthritis and Tissue Degeneration Program, Hospital for Special Surgery , New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel B","family":"Ivashkiv","sequence":"additional","affiliation":[{"name":"Arthritis and Tissue Degeneration Program, Hospital for Special Surgery , New York, NY 10021"},{"name":"Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,5,15]]},"reference":[{"key":"2026012806283418400_r1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0092-8674(02)01201-1","article-title":"Pattern recognition receptors: doubling up for the innate immune response.","volume":"111","author":"Gordon","year":"2002","journal-title":"Cell"},{"key":"2026012806283418400_r2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.127.3301.756.b","article-title":"On the composition of zymosan.","volume":"127","author":"Di Carlo","year":"1958","journal-title":"Science"},{"key":"2026012806283418400_r3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1084\/jem.20021890","article-title":"Dectin-1 mediates the biological effects of \u03b2-glucans.","volume":"197","author":"Brown","year":"2003","journal-title":"J. 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