{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:06:03Z","timestamp":1773108363642,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the thymus, the transcription factor ThPOK is essential for the development of the CD4 helper T cell lineage, whereas active repression of ThPOK is critical for the development of the CD8 cytotoxic T cell lineage. ThPOK gene silencing is thought to be irreversible in peripheral CD8 T cells. We noticed that ThPOK repression is readily abrogated upon in vitro TCR stimulation of peripheral CD8 T cells. This observation prompted us to investigate a role for ThPOK in the CD8 T cell response to an acute viral infection. We observed that a functional deficiency of ThPOK does not affect CD8 T cell differentiation into effector T cells and the long-term persistence of Ag-specific memory T cells. However, in the absence of functional ThPOK, clonal expansion is significantly less in both primary and secondary CD8 T cell responses. Long-lived, Ag-specific CD8 T cells with a functional deficiency in ThPOK fail to produce high amounts of IL-2 and also fail to express high levels of granzyme B upon rechallenge. Our data reveal an unexpected role for ThPOK in CD8 T cells in promoting expansion and boosting the response to antigenic challenge.<\/jats:p>","DOI":"10.4049\/jimmunol.0901428","type":"journal-article","created":{"date-parts":[[2009,9,5]],"date-time":"2009-09-05T00:55:29Z","timestamp":1252112129000},"page":"4467-4474","source":"Crossref","is-referenced-by-count":25,"title":["ThPOK Derepression Is Required for Robust CD8 T cell Responses to Viral Infection"],"prefix":"10.1093","volume":"183","author":[{"given":"Ruka","family":"Setoguchi","sequence":"first","affiliation":[{"name":"Department of Immunology and the Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Taniuchi","sequence":"additional","affiliation":[{"name":"Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology , Yokohama,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Bevan","sequence":"additional","affiliation":[{"name":"Department of Immunology and the Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"2025032620140431100_R1","first-page":"837","article-title":"Molecular and functional profiling of memory CD8 T cell differentiation.","volume-title":"Cell","year":"2002"},{"key":"2025032620140431100_R2","first-page":"171","article-title":"Effector and memory CTL differentiation.","volume-title":"Annu. 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