{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:30:23Z","timestamp":1769646623557,"version":"3.49.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accumulating evidence suggests that the dichotomy between tolerance and active IgA immunity in mucosal immune responses is regulated at the APC level. Therefore, immunomodulation of the APC could be an effective mechanism to control the two response patterns. In this study, we demonstrate that ADP-ribosylation controls the outcome of tolerance or active effector T cell immunity to an internal peptide p323\u2013339 from OVA inserted into the cholera toxin (CT)-derived CTA1-OVA-DD adjuvant. We found that a single point mutation, CTA1R7K-OVA-DD, resulting in lack of enzymatic activity, promoted peptide-specific tolerance in TCR transgenic CD4+ T cells following a single intranasal (i.n.) treatment. The CTA1R7K-OVA-DD\u2013induced tolerance was strong, long-lasting, and impaired the ability of adoptively transferred naive peptide-specific CD4+ T cells to respond to Ag-challenge, irrespective if this was given i.p or i.n. The tolerance correlated with induction of regulatory T cells of the regulatory T type 1 characterized by CD25\u2212Foxp3\u2212CD4+ T cells producing IL-10. In contrast, in IL-10\u2013deficient mice, no peptide-specific tolerance was observed, and these mice exhibited unimpaired CD4+ T cell responsiveness to recall Ag irrespective of if they were untreated (PBS) or treated i.n. with CTA1R7K-OVA-DD. Thus, for the first time, we can provide unequivocal proof that ADP-ribosylation can control the outcome of mucosal Ag exposure from tolerance to an enhanced effector CD4+ T cell response. The exploitation of this system for clinical treatment of autoimmune diseases is discussed.<\/jats:p>","DOI":"10.4049\/jimmunol.0901445","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T20:44:50Z","timestamp":1265661890000},"page":"2776-2784","source":"Crossref","is-referenced-by-count":8,"title":["ADP-Ribosylation Controls the Outcome of Tolerance or Enhanced Priming Following Mucosal Immunization"],"prefix":"10.1093","volume":"184","author":[{"given":"Annemarie","family":"Hasselberg","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Institute of Biomedicine, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Ekman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Institute of Biomedicine, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Fahl\u00e9n","family":"Yrlid","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Institute of Biomedicine, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Institute of Biomedicine, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils Y","family":"Lycke","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Institute of Biomedicine, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,3,15]]},"reference":[{"key":"2026012806281977800_r1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.0105-2896.2005.00280.x","article-title":"Oral tolerance.","volume":"206","author":"Faria","year":"2005","journal-title":"Immunol. Rev."},{"key":"2026012806281977800_r2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1057","article-title":"Anatomical basis of tolerance and immunity to intestinal antigens.","volume":"3","author":"Mowat","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"2026012806281977800_r3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0167-7799(01)01670-5","article-title":"Immunomodulators and delivery systems for vaccination by mucosal routes.","volume":"19","author":"Ryan","year":"2001","journal-title":"Trends Biotechnol."},{"key":"2026012806281977800_r4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nri1777","article-title":"Mucosal vaccines: the promise and the challenge.","volume":"6","author":"Neutra","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2026012806281977800_r5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pharmthera.2008.11.007","article-title":"Allergen-related approaches to immunotherapy.","volume":"121","author":"Rolland","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"2026012806281977800_r6","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.4049\/jimmunol.179.9.5633","article-title":"Perspectives on mucosal vaccines: is mucosal tolerance a barrier?","volume":"179","author":"Mestecky","year":"2007","journal-title":"J. Immunol."},{"key":"2026012806281977800_r7","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2174\/092986707781696609","article-title":"Sublingual allergen immunotherapy: immunological mechanisms and prospects for refined vaccine preparation.","volume":"14","author":"O\u2019Hehir","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"2026012806281977800_r8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1615\/CritRevImmunol.v24.i3.10","article-title":"Regulation of antigen-specific regulatory T-cell induction via nasal and oral mucosa.","volume":"24","author":"Samsom","year":"2004","journal-title":"Crit. Rev. Immunol."},{"key":"2026012806281977800_r9","first-page":"143","article-title":"Oral tolerance: therapeutic implications for autoimmune diseases.","volume":"13","author":"Faria","year":"2006","journal-title":"Clin. Dev. Immunol."},{"key":"2026012806281977800_r10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/mi.2007.22","article-title":"Vitamin A rewrites the ABCs of oral tolerance.","volume":"1","author":"Strober","year":"2008","journal-title":"Mucosal Immunol."},{"key":"2026012806281977800_r11","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.4049\/jimmunol.177.10.7346","article-title":"Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node.","volume":"177","author":"Hintzen","year":"2006","journal-title":"J. Immunol."},{"key":"2026012806281977800_r12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1189\/jlb.1103534","article-title":"Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent.","volume":"75","author":"Lavelle","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2026012806281977800_r13","doi-asserted-by":"crossref","DOI":"10.1002\/9780470134931.ch3","article-title":"Mechanisms of adjuvant action.","volume-title":"Vaccine Adjuvants and Delivery Systems","author":"Lycke","year":"2007"},{"key":"2026012806281977800_r14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1086\/315694","article-title":"Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses.","volume":"182","author":"Yamamoto","year":"2000","journal-title":"J. Infect. Dis."},{"key":"2026012806281977800_r15","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1189\/jlb.1207850","article-title":"Cholera toxin B subunit promotes the induction of regulatory T cells by preventing human dendritic cell maturation.","volume":"84","author":"D\u2019Ambrosio","year":"2008","journal-title":"J. Leukoc. Biol."},{"issue":"4","key":"2026012806281977800_r16","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1038\/nm1213","article-title":"Mucosal immunity and vaccines.","volume":"11","author":"Holmgren","year":"2005","journal-title":"Nat. Med."},{"key":"2026012806281977800_r17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-5699(98)01397-8","article-title":"Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic.","volume":"20","author":"Williams","year":"1999","journal-title":"Immunol. Today"},{"key":"2026012806281977800_r18","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1084\/jem.187.7.1123","article-title":"Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.","volume":"187","author":"Giuliani","year":"1998","journal-title":"J. Exp. Med."},{"key":"2026012806281977800_r19","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.4049\/jimmunol.177.5.3045","article-title":"A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking.","volume":"177","author":"Hagiwara","year":"2006","journal-title":"J. Immunol."},{"key":"2026012806281977800_r20","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.4049\/jimmunol.158.8.3936","article-title":"Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.","volume":"158","author":"Agren","year":"1997","journal-title":"J. Immunol."},{"key":"2026012806281977800_r21","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.4049\/jimmunol.162.4.2432","article-title":"Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity.","volume":"162","author":"Agren","year":"1999","journal-title":"J. Immunol."},{"key":"2026012806281977800_r22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-3083.2005.01713.x","article-title":"The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization.","volume":"63","author":"Akhiani","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"2026012806281977800_r23","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.vaccine.2007.12.027","article-title":"CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.","volume":"26","author":"Eliasson","year":"2008","journal-title":"Vaccine"},{"key":"2026012806281977800_r24","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.4049\/jimmunol.173.5.3310","article-title":"The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues.","volume":"173","author":"Eriksson","year":"2004","journal-title":"J. Immunol."},{"key":"2026012806281977800_r25","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.4049\/jimmunol.165.9.4778","article-title":"Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues.","volume":"165","author":"van Ginkel","year":"2000","journal-title":"J. Immunol."},{"key":"2026012806281977800_r26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1084\/jem.180.1.25","article-title":"Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.","volume":"180","author":"Kirberg","year":"1994","journal-title":"J. Exp. Med."},{"key":"2026012806281977800_r27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis.","volume":"75","author":"K\u00fchn","year":"1993","journal-title":"Cell"},{"key":"2026012806281977800_r28","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.2125367","article-title":"Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.","volume":"250","author":"Murphy","year":"1990","journal-title":"Science"},{"key":"2026012806281977800_r29","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.4049\/jimmunol.175.8.5192","article-title":"Splenic marginal zone dendritic cells mediate the cholera toxin adjuvant effect: dependence on the ADP-ribosyltransferase activity of the holotoxin.","volume":"175","author":"Grdic","year":"2005","journal-title":"J. Immunol."},{"key":"2026012806281977800_r30","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1084\/jem.182.5.1579","article-title":"The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-\u03b1\u03b2-transgenic model.","volume":"182","author":"Hosken","year":"1995","journal-title":"J. Exp. Med."},{"key":"2026012806281977800_r31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.immunol.21.120601.141110","article-title":"T cell anergy.","volume":"21","author":"Schwartz","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"2026012806281977800_r32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.0105-2896.2006.00420.x","article-title":"Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.","volume":"212","author":"Roncarolo","year":"2006","journal-title":"Immunol. Rev."},{"key":"2026012806281977800_r33","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.4049\/jimmunol.181.10.7230","article-title":"Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma.","volume":"181","author":"Henry","year":"2008","journal-title":"J. Immunol."},{"key":"2026012806281977800_r34","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.4049\/jimmunol.180.8.5187","article-title":"Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1.","volume":"180","author":"Rynda","year":"2008","journal-title":"J. Immunol."},{"key":"2026012806281977800_r35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2008.00711.x","article-title":"Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation.","volume":"226","author":"Maynard","year":"2008","journal-title":"Immunol. Rev."},{"key":"2026012806281977800_r36","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ni1504","article-title":"Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10.","volume":"8","author":"Maynard","year":"2007","journal-title":"Nat. Immunol."},{"key":"2026012806281977800_r37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","article-title":"A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.","volume":"389","author":"Groux","year":"1997","journal-title":"Nature"},{"key":"2026012806281977800_r38","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.172.9.5213","article-title":"Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-\u03b2, and IL-10.","volume":"172","author":"Zheng","year":"2004","journal-title":"J. Immunol."},{"key":"2026012806281977800_r39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine.","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol. Rev."},{"key":"2026012806281977800_r40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.coph.2006.01.010","article-title":"Understanding and exploiting the endogenous interleukin-10\/STAT3-mediated anti-inflammatory response.","volume":"6","author":"Murray","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"2026012806281977800_r41","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1074-7613(03)00232-2","article-title":"A critical role for Stat3 signaling in immune tolerance.","volume":"19","author":"Cheng","year":"2003","journal-title":"Immunity"},{"key":"2026012806281977800_r42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nri2097","article-title":"T(H)1 cells control themselves by producing interleukin-10.","volume":"7","author":"O\u2019Garra","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2026012806281977800_r43","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.174.4.915","article-title":"Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.","volume":"174","author":"de Waal Malefyt","year":"1991","journal-title":"J. Exp. Med."},{"key":"2026012806281977800_r44","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL-10 inhibits cytokine production by activated macrophages.","volume":"147","author":"Fiorentino","year":"1991","journal-title":"J. Immunol."},{"key":"2026012806281977800_r45","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4049\/jimmunol.151.3.1224","article-title":"IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.","volume":"151","author":"Ding","year":"1993","journal-title":"J. Immunol."},{"key":"2026012806281977800_r46","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1182\/blood.V81.11.2964.2964","article-title":"Human interleukin-10 can directly inhibit T-cell growth.","volume":"81","author":"Taga","year":"1993","journal-title":"Blood"},{"key":"2026012806281977800_r47","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/eji.200838773","article-title":"IL-10 interferes directly with TCR-induced IFN-\u03b3 but not IL-17 production in memory T cells.","volume":"39","author":"Naundorf","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2026012806281977800_r48","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.4049\/jimmunol.163.5.2592","article-title":"Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells.","volume":"163","author":"Tsitoura","year":"1999","journal-title":"J. Immunol."},{"key":"2026012806281977800_r49","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.imbio.2009.01.012","article-title":"Different mechanisms regulate CD4+ T cell independent induction of oral and nasal tolerance of CD8+ T cells.","volume":"215","author":"van den Berg","year":"2009","journal-title":"Immunobiology"},{"key":"2026012806281977800_r50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-3083.2006.01823.x","article-title":"Sublingual tolerance induction with antigen conjugated to cholera toxin B subunit induces Foxp3+CD25+CD4+ regulatory T cells and suppresses delayed-type hypersensitivity reactions.","volume":"64","author":"Sun","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"2026012806281977800_r51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1073\/pnas.93.1.226","article-title":"Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets.","volume":"93","author":"Nashar","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026012806281977800_r52","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.4049\/jimmunol.177.11.7634","article-title":"Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells.","volume":"177","author":"Sun","year":"2006","journal-title":"J. Immunol."},{"key":"2026012806281977800_r53","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.4049\/jimmunol.181.12.8278","article-title":"B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B subunit.","volume":"181","author":"Sun","year":"2008","journal-title":"J. Immunol."},{"key":"2026012806281977800_r54","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa030595","article-title":"Use of the inactivated intranasal influenza vaccine and the risk of Bell\u2019s palsy in Switzerland.","volume":"350","author":"Mutsch","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2026012806281977800_r55","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/art.24566","article-title":"Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis.","volume":"60","author":"Hasselberg","year":"2009","journal-title":"Arthritis Rheum."},{"key":"2026012806281977800_r56","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/art.21647","article-title":"Antigen-induced, tolerogenic CD11c+,CD11b+ dendritic cells are abundant in Peyer\u2019s patches during the induction of oral tolerance to type II collagen and suppress experimental collagen-induced arthritis.","volume":"54","author":"Min","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2026012806281977800_r57","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1471-4906(01)01959-7","article-title":"Designer dendritic cells for tolerance induction: guided not misguided missiles.","volume":"22","author":"Hackstein","year":"2001","journal-title":"Trends Immunol."},{"key":"2026012806281977800_r58","doi-asserted-by":"crossref","first-page":"R141","DOI":"10.1186\/ar2031","article-title":"Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine.","volume":"8","author":"Popov","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"2026012806281977800_r59","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.4049\/jimmunol.177.6.3806","article-title":"Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells.","volume":"177","author":"Charbonnier","year":"2006","journal-title":"J. Immunol."},{"key":"2026012806281977800_r60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2567.2008.02875.x","article-title":"Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo.","volume":"126","author":"Jaen","year":"2008","journal-title":"Immunology"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/6\/2776\/62717636\/ji_0901445.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/6\/2776\/62717636\/ji_0901445.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:30:38Z","timestamp":1769599838000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/6\/2776\/8006847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":60,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,3,15]]},"published-print":{"date-parts":[[2010,3,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0901445","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,3]]},"published":{"date-parts":[[2010,3]]}}}