{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:56:23Z","timestamp":1781304983442,"version":"3.54.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The 129-derived Sle16 is a susceptibility locus for systemic autoimmunity when present on the C57BL\/6 (B6) background. Genetic analysis of a (129\u00d7B6)F2 cross identified a region from the B6 chromosome 3 (Sle18) with positive linkage to antinuclear Abs. In this study, we have generated a B6 congenic strain harboring the 129 allele of Sle18 and intercrossed this line with the lupus-prone B6.129-Sle16 strain. The presence of the 129-Sle18 allele in the B6.129-Sle16Sle18 double congenic mice suppressed the development of Sle16-mediated autoantibody production and ameliorated the renal pathology. The 129-Sle18 locus rectified the B cell abnormalities detected in the B6.129-Sle16 mice, such as the reduction in the percentage of marginal zone B and B1a cells and the increased number of germinal centers. The B6.129-Sle16Sle18 spleens still displayed an increased percentage of activated T and B cells. However, in the B6.129-Sle16Sle18 strain the percentage of naive T cells was equivalent to that in B6.129-Sle18 and B6 mice and these cells showed a reduced proliferative response to anti-CD3 stimulation compared with B6.129-Sle16 T cells. There was a significant increase in the percentage of CD4+FoxP3+regulatory T cells in all congenic strains. These cells had normal regulatory function when tested in vitro. Thus, 129-Sle18 represents a novel, non-MHC lupus-suppressor locus probably operating as a functional modifier of B cells that, in combination with other factors, leads to lupus resistance. Further characterization of this locus will help to uncover the immune mechanism(s) conferring protection against lupus.<\/jats:p>","DOI":"10.4049\/jimmunol.0901463","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T22:16:05Z","timestamp":1272665765000},"page":"6256-6265","source":"Crossref","is-referenced-by-count":12,"title":["Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3"],"prefix":"10.1093","volume":"184","author":[{"given":"Francesco","family":"Carlucci","sequence":"first","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Fossati-Jimack","sequence":"additional","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E","family":"Dumitriu","sequence":"additional","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Heidari","sequence":"additional","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Walport","sequence":"additional","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Szajna","sequence":"additional","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramita","family":"Baruah","sequence":"additional","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver A","family":"Garden","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, The Royal Veterinary College , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Terence","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Faculty of Medicine, Imperial College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Botto","sequence":"additional","affiliation":[{"name":"Rheumatology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"key":"2026012806263738900_r1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(06)92001-X","article-title":"Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease.","volume":"92","author":"Fairhurst","year":"2006","journal-title":"Adv. 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