{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:39:01Z","timestamp":1791275941613,"version":"4.1.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-27 is formed by the association of a cytokine subunit, p28, with the soluble cytokine receptor EBV-induced gene 3 (EBI3). The IL-27R comprises gp130 and WSX-1. The marked difference between EBI3\u2212\/\u2212 and WSX-1\u2212\/\u2212 mice suggests that p28 has functions independent of EBI3. We have identified an alternative secreted complex formed by p28 and the soluble cytokine receptor cytokine-like factor 1 (CLF). Like IL-27, p28\/CLF is produced by dendritic cells and is biologically active on human NK cells, increasing IL-12- and IL-2-induced IFN-\u03b3 production and activation marker expression. Experiments with Ba\/F3 transfectants indicate that p28\/CLF activates cells expressing IL-6R\u03b1 in addition to the IL-27R subunits. When tested on CD4 and CD8 T cells, p28\/CLF induces IL-6R\u03b1-dependent STAT1 and STAT3 phosphorylation. Furthermore, p28\/CLF inhibits CD4 T cell proliferation and induces IL-17 and IL-10 secretion. These results indicate that p28\/CLF may participate in the regulation of NK and T cell functions by dendritic cells. The p28\/CLF complex engages IL-6R and may therefore be useful for therapeutic applications targeting cells expressing this receptor. Blocking IL-6R using humanized mAbs such as tocilizumab has been shown to be beneficial in pathologies like rheumatoid arthritis and juvenile idiopathic arthritis. The identification of a new IL-6R ligand is therefore important for a complete understanding of the mechanism of action of this emerging class of immunosuppressors.<\/jats:p>","DOI":"10.4049\/jimmunol.0901464","type":"journal-article","created":{"date-parts":[[2009,11,23]],"date-time":"2009-11-23T22:59:20Z","timestamp":1259017160000},"page":"7692-7702","source":"Crossref","is-referenced-by-count":126,"title":["The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling"],"prefix":"10.1093","volume":"183","author":[{"given":"Sandrine","family":"Crab\u00e9","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie"},{"name":"Groupement Universitaire de Recherche sur le M\u00e9dicament, Universit\u00e9 de Montr\u00e9al , Montreal,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Guay-Giroux","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie Jeanne","family":"Tormo","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie"},{"name":"Groupement Universitaire de Recherche sur le M\u00e9dicament, Universit\u00e9 de Montr\u00e9al , Montreal,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Duluc","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers, Angers; Universit\u00e9 d\u2019Angers, Unit\u00e9 Mixte de Recherche-Sant\u00e9 892 , Angers,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Lissilaa","sequence":"additional","affiliation":[{"name":"NovImmune SA , Plan-les-Ouates,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Guilhot","sequence":"additional","affiliation":[{"name":"NovImmune SA , Plan-les-Ouates,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrick","family":"Mavoungou-Bigouagou","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers, Angers; Universit\u00e9 d\u2019Angers, Unit\u00e9 Mixte de Recherche-Sant\u00e9 892 , Angers,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Lefouili","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cognet","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ferlin","sequence":"additional","affiliation":[{"name":"NovImmune SA , Plan-les-Ouates,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Elson","sequence":"additional","affiliation":[{"name":"NovImmune SA , Plan-les-Ouates,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Jeannin","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers, Angers; Universit\u00e9 d\u2019Angers, Unit\u00e9 Mixte de Recherche-Sant\u00e9 892 , Angers,","place":["France"]},{"name":"Laboratoire d\u2019Immunologie et d\u2019Allergologie, Centre Hospitalier Universitaire d\u2019Angers , Angers,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Gauchat","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie"},{"name":"Groupement Universitaire de Recherche sur le M\u00e9dicament, Universit\u00e9 de Montr\u00e9al , Montreal,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,15]]},"reference":[{"key":"2026012811242699900_R1","first-page":"779","article-title":"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.","volume-title":"Immunity","year":"2002"},{"key":"2026012811242699900_R2","first-page":"2225","article-title":"WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012811242699900_R3","first-page":"2479","article-title":"Induction of IgG2a class switching in B cells by IL-27.","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012811242699900_R4","first-page":"916","article-title":"Development of Th1-type immune responses requires the type I cytokine receptor TCCR.","volume-title":"Nature","year":"2000"},{"key":"2026012811242699900_R5","first-page":"569","article-title":"WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection.","volume-title":"Immunity","year":"2001"},{"key":"2026012811242699900_R6","first-page":"645","article-title":"The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.","volume-title":"Immunity","year":"2003"},{"key":"2026012811242699900_R7","first-page":"5626","article-title":"The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity.","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012811242699900_R8","first-page":"657","article-title":"WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.","volume-title":"Immunity","year":"2003"},{"key":"2026012811242699900_R9","first-page":"158","article-title":"Interleukin-27R (WSX-1\/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology.","volume-title":"Am. J. Pathol.","year":"2006"},{"key":"2026012811242699900_R10","first-page":"929","article-title":"Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.","volume-title":"Nat. Immunol.","year":"2006"},{"key":"2026012811242699900_R11","first-page":"937","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.","volume-title":"Nat. Immunol.","year":"2006"},{"key":"2026012811242699900_R12","first-page":"7490","article-title":"IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice.","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012811242699900_R13","first-page":"2773","article-title":"IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.","volume-title":"J. Immunol.","year":"2006"},{"key":"2026012811242699900_R14","first-page":"237","article-title":"IL-27 limits IL-2 production during Th1 differentiation.","volume-title":"J. Immunol.","year":"2006"},{"key":"2026012811242699900_R15","first-page":"1380","article-title":"A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.","volume-title":"Nat. Immunol.","year":"2007"},{"key":"2026012811242699900_R16","first-page":"1372","article-title":"Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.","volume-title":"Nat. Immunol.","year":"2007"},{"key":"2026012811242699900_R17","first-page":"1363","article-title":"Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.","volume-title":"Nat. Immunol","year":"2007"},{"key":"2026012811242699900_R18","first-page":"3268","article-title":"Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis.","volume-title":"J. Immunol.","year":"2007"},{"key":"2026012811242699900_R19","first-page":"30","article-title":"Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitis.","volume-title":"J. Immunol.","year":"2008"},{"key":"2026012811242699900_R20","first-page":"3590","article-title":"Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis.","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012811242699900_R21","first-page":"16951","article-title":"Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice.","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026012811242699900_R22","first-page":"867","article-title":"CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.","volume-title":"Nat. Neurosci.","year":"2000"},{"key":"2026012811242699900_R23","first-page":"1371","article-title":"Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family.","volume-title":"J. Immunol.","year":"1998"},{"key":"2026012811242699900_R24","first-page":"53","article-title":"Cardiotrophin-like cytokine labelling using Bir A biotin ligase: a sensitive tool to study receptor expression by immune and non-immune cells.","volume-title":"J. Immunol. Methods","year":"2005"},{"key":"2026012811242699900_R25","first-page":"142","article-title":"I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion.","volume-title":"Nat. Biotechnol.","year":"1997"},{"key":"2026012811242699900_R26","first-page":"145","article-title":"A novel bulk-culture method for generating mature dendritic cells from mouse bone marrow cells.","volume-title":"J. Immunol. Methods","year":"2002"},{"key":"2026012811242699900_R27","first-page":"5649","article-title":"Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1\u03b1 cDNA.","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1988"},{"key":"2026012811242699900_R28","first-page":"141","article-title":"Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-\u03b3-mediated pathways.","volume-title":"J. Exp. Med.","year":"2007"},{"key":"2026012811242699900_R29","first-page":"157","article-title":"Dendritic cell-NK cell cross-talk: regulation and physiopathology.","volume-title":"Curr. Top. Microbiol. Immunol.","year":"2006"},{"key":"2026012811242699900_R30","first-page":"737","article-title":"Structural organization of a full-length gp130\/LIF-R cytokine receptor transmembrane complex.","volume-title":"Mol. Cell","year":"2008"},{"key":"2026012811242699900_R31","first-page":"2399","article-title":"Receptor recognition by gp130 cytokines.","volume-title":"EMBO J.","year":"2000"},{"key":"2026012811242699900_R32","first-page":"43961","article-title":"Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC\/CLF and CLC\/sCNTFR\u03b1 composite cytokines.","volume-title":"J. Biol. Chem.","year":"2004"},{"key":"2026012811242699900_R33","first-page":"235","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.","volume-title":"Nature","year":"2006"},{"key":"2026012811242699900_R34","first-page":"231","article-title":"Transforming growth factor-\u03b2 induces development of the TH17 lineage.","volume-title":"Nature","year":"2006"},{"key":"2026012811242699900_R35","first-page":"179","article-title":"TGF\u03b2 in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.","volume-title":"Immunity","year":"2006"},{"key":"2026012811242699900_R36","first-page":"7607","article-title":"IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3.","volume-title":"J. Immunol.","year":"2007"},{"key":"2026012811242699900_R37","first-page":"9528","article-title":"Signaling of human ciliary neurotrophic factor (CNTF) revisited: the interleukin-6 receptor can serve as an \u03b1-receptor for CTNF.","volume-title":"J. Biol. Chem.","year":"2003"},{"key":"2026012811242699900_R38","first-page":"1692","article-title":"The ciliary neurotrophic factor receptor \u03b1 component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.","volume-title":"EMBO J.","year":"2001"},{"key":"2026012811242699900_R39","first-page":"22476","article-title":"Signaling pathways recruited by the cardiotrophin-like cytokine\/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor \u03b1 component.","volume-title":"J. Biol. Chem.","year":"2001"},{"key":"2026012811242699900_R40","first-page":"109","article-title":"The wolf in sheep\u2019s clothing: the role of interleukin-6 in immunity, inflammation and cancer.","volume-title":"Trends Mol. Med.","year":"2008"},{"key":"2026012811242699900_R41","first-page":"2633","article-title":"Human monocyte-derived and CD83+ blood dendritic cells enhance NK cell-mediated cytotoxicity.","volume-title":"Eur. J. Immunol.","year":"2001"},{"key":"2026012811242699900_R42","first-page":"1011","article-title":"Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.","volume-title":"Nat. Immunol.","year":"2005"},{"key":"2026012811242699900_R43","first-page":"405","article-title":"Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.","volume-title":"Nat. Med.","year":"1999"},{"key":"2026012811242699900_R44","first-page":"1590","article-title":"Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells.","volume-title":"J. Immunol.","year":"2001"},{"key":"2026012811242699900_R45","first-page":"327","article-title":"Reciprocal activating interaction between natural killer cells and dendritic cells.","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026012811242699900_R46","first-page":"175","article-title":"Functional interactions between dendritic cells and NK cells during viral infection.","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2026012811242699900_R47","first-page":"2375","article-title":"Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells.","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026012811242699900_R48","first-page":"1138","article-title":"An absolute and restricted requirement for IL-12 in natural killer cell IFN-\u03b3 production and antiviral defense: studies of natural killer and T cell responses in contrasting viral infections.","volume-title":"J. Immunol.","year":"1996"},{"key":"2026012811242699900_R49","first-page":"2252","article-title":"Natural-killer cells and dendritic cells: \u201cl\u2019union fait la force.\u201d.","volume-title":"Blood","year":"2005"},{"key":"2026012811242699900_R50","first-page":"16606","article-title":"Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2004"},{"key":"2026012811242699900_R51","first-page":"189","article-title":"Natural killer cells in antiviral defense: function and regulation by innate cytokines.","volume-title":"Annu. Rev. Immunol.","year":"1999"},{"key":"2026012811242699900_R52","first-page":"3594","article-title":"Cutting edge: murine dendritic cells require IL-15R\u03b1 to prime NK cells.","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012811242699900_R53","first-page":"4279","article-title":"Coordinated and distinct roles for IFN-\u03b1\u03b2, IL-12, and IL-15 regulation of NK cell responses to viral infection.","volume-title":"J. Immunol.","year":"2002"},{"key":"2026012811242699900_R54","first-page":"187","article-title":"Biology of natural killer cells.","volume-title":"Adv. Immunol.","year":"1989"},{"key":"2026012811242699900_R55","first-page":"15047","article-title":"IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026012811242699900_R56","first-page":"4886","article-title":"Cutting edge: role of IL-27\/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.","volume-title":"J. Immunol.","year":"2003"},{"key":"2026012811242699900_R57","first-page":"2366","article-title":"Characterization of the murine immunological signaling network with phosphospecific flow cytometry.","volume-title":"J. Immunol.","year":"2005"},{"key":"2026012811242699900_R58","first-page":"105","article-title":"Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy.","volume-title":"Immunity","year":"2001"},{"key":"2026012811242699900_R59","first-page":"87","article-title":"Th17 cells in human disease.","volume-title":"Immunol. Rev.","year":"2008"},{"key":"2026012811242699900_R60","first-page":"1173","article-title":"Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.","volume-title":"Nat. Med.","year":"2007"},{"key":"2026012811242699900_R61","first-page":"425","article-title":"T(H)1 cells control themselves by producing interleukin-10.","volume-title":"Nat. Rev. Immunol.","year":"2007"},{"key":"2026012811242699900_R62","first-page":"239","article-title":"Interleukin-10 production by effector T cells: Th1 cells show self control.","volume-title":"J. Exp. Med.","year":"2007"},{"key":"2026012811242699900_R63","first-page":"263","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis.","volume-title":"Cell","year":"1993"},{"key":"2026012811242699900_R64","first-page":"798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-\u03b3 and TNF-\u03b1.","volume-title":"J. Immunol.","year":"1996"},{"key":"2026012811242699900_R65","first-page":"357","article-title":"IL-6 in autoimmune disease and chronic inflammatory proliferative disease.","volume-title":"Cytokine Growth Factor Rev.","year":"2002"},{"key":"2026012811242699900_R66","first-page":"227","article-title":"Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.","volume-title":"J. Leukocyte Biol.","year":"2006"},{"key":"2026012811242699900_R67","first-page":"1413","article-title":"Tocilizumab: the first interleukin-6-receptor inhibitor.","volume-title":"Am. J. Health Syst. Pharm.","year":"2008"},{"key":"2026012811242699900_R68","first-page":"2627","article-title":"Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.","volume-title":"Blood","year":"2005"},{"key":"2026012811242699900_R69","first-page":"987","article-title":"Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.","volume-title":"Lancet","year":"2008"},{"key":"2026012811242699900_R70","first-page":"1761","article-title":"Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial.","volume-title":"Arthritis Rheum.","year":"2004"},{"key":"2026012811242699900_R71","first-page":"1580","article-title":"Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study.","volume-title":"Ann. Rheum. Dis.","year":"2008"},{"key":"2026012811242699900_R72","first-page":"998","article-title":"Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial.","volume-title":"Lancet","year":"2008"},{"key":"2026012811242699900_R73","first-page":"989","article-title":"A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn\u2019s disease.","volume-title":"Gastroenterology","year":"2004"},{"key":"2026012811242699900_R74","first-page":"957","article-title":"Actemra poised to launch IL-6 inhibitors.","volume-title":"Nat. Biotechnol.","year":"2008"},{"key":"2026012811242699900_R75","first-page":"107","article-title":"GM poplars to grow next door.","volume-title":"Nat. Biotechnol.","year":"2009"},{"key":"2026012811242699900_R76","first-page":"1662","article-title":"Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.","volume-title":"Arthritis Rheum.","year":"2006"},{"key":"2026012811242699900_R77","first-page":"3202","article-title":"Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130.","volume-title":"J. Immunol.","year":"2003"},{"key":"2026012811242699900_R78","first-page":"583","article-title":"Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo.","volume-title":"Nat. Med.","year":"2000"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/183\/12\/7692\/62693076\/0130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/183\/12\/7692\/62693076\/0130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:26:05Z","timestamp":1769617565000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/183\/12\/7692\/8053294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":78,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,12,15]]},"published-print":{"date-parts":[[2009,12,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0901464","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2009,12]]},"published":{"date-parts":[[2009,12]]}}}