{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:22:40Z","timestamp":1791400960121,"version":"4.3.3"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b3\u03b4 T cells, a major innate-like T cell subset, are thought to play in vivo an important role in innate and adaptive immune responses to various infection agents like parasites, bacteria, or viruses but the mechanisms contributing to this immune process remain ill defined. Owing to their ability to recognize a broad set of microbial molecular patterns, TLRs represent a major innate pathway through which pathogens induce dendritic cells (DC) maturation and acquisition of immunostimulatory functions. In this study, we studied the effects of various TLR ligands on the activation of human V\u03b39V\u03b42 T cells, a main human \u03b3\u03b4 PBL subset, which has been recently involved in the licensing of mycobacteria-infected DC. Both TLR3 and TLR4, but not TLR2 ligands, induced a rapid, strong, and exclusive IFN-\u03b3 production by V\u03b39V\u03b42 T cells. This \u03b3\u03b4 subset contributed to a large extent to the overall PBL IFN-\u03b3 response induced after short-term TLR stimulation of human PBMC. Importantly, this phenomenon primarily depended on type I IFN, but not IL-12, produced by monocytic DC upon TLR engagement. V\u03b39V\u03b42 T cells were similarly activated by plasmacytoid DC upon TLR8\/9 activation or Yellow Fever virus infection. Moreover TLR-induced V\u03b39V\u03b42 IFN-\u03b3 noncytolytic response led to efficient DC polarization into IL-12p70-producing cells. Our results support an adjuvant role played by V\u03b39V\u03b42 T cells along microbial infections through a particular cross-talk with pathogen-associated molecular patterns-activated DC. Moreover they provide new insights into the mechanisms underlying functional activation of this unique peripheral innate-like T cell subset during viral infections.<\/jats:p>","DOI":"10.4049\/jimmunol.0901571","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T22:24:00Z","timestamp":1251325440000},"page":"3625-3633","source":"Crossref","is-referenced-by-count":83,"title":["Early Triggering of Exclusive IFN-\u03b3 Responses of Human V\u03b39V\u03b42 T Cells by TLR-Activated Myeloid and Plasmacytoid Dendritic Cells"],"prefix":"10.1093","volume":"183","author":[{"given":"Marie-Claire","family":"Devilder","sequence":"first","affiliation":[{"name":"INSERM, U892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers , Nantes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Allain","sequence":"additional","affiliation":[{"name":"INSERM, U892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers , Nantes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Dousset","sequence":"additional","affiliation":[{"name":"INSERM, U892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers , Nantes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bonneville","sequence":"additional","affiliation":[{"name":"INSERM, U892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers , Nantes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Scotet","sequence":"additional","affiliation":[{"name":"INSERM, U892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers , Nantes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,9,15]]},"reference":[{"key":"2026012811273313900_R1","first-page":"197","article-title":"Innate immune recognition.","volume-title":"Annu. 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