{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:23:06Z","timestamp":1791969786447,"version":"4.3.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Th17 is a newly identified lineage of effector T cells involved in autoimmunity and immune responses to pathogens. We demonstrate in this study the pathogenic role of IL-17\u2013producing CD4+ T lymphocytes in allergic contact dermatitis (ACD) to skin-applied chemicals. IL-17+ T cells infiltrate ACD reactions and predominantly distribute at the site of heavy spongiosis. Skin IL-17+ T cells were functionally and phenotypically heterogeneous: although pure Th17 prevailed in ACD skin, hapten responsiveness was restricted to Th1\/IL-17 (IFN-\u03b3+IL-17+) and Th0\/IL-17 (IFN-\u03b3+IL-17+IL-4+) fractions, and to lesser extent Th2\/IL-17 cells. In the IFN-\u03b3\u2013dominated ACD environment, IL-17\u2013releasing T cells affect immune function of keratinocytes by promoting CXCL8, IL-6, and HBD-2 production. In addition, compared with Th1, supernatants from Th1\/IL-17 T cells were much more efficient in inducing ICAM-1 expression on keratinocytes and keratinocyte\u2013T cell adhesiveness in vitro. As a consequence, exposure to combined IFN-\u03b3 and IL-17 rendered keratinocytes susceptible to ICAM-1\u2013dependent Ag nonspecific T cell killing. Thus, IL-17 efficiently amplifies the allergic reaction by rendering virtually all of the T lymphocytes recruited at the site of skin inflammation capable to directly contribute to tissue damage.<\/jats:p>","DOI":"10.4049\/jimmunol.0901767","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T23:07:42Z","timestamp":1270076862000},"page":"4880-4888","source":"Crossref","is-referenced-by-count":105,"title":["IL-17 Amplifies Human Contact Hypersensitivity by Licensing Hapten Nonspecific Th1 Cells to Kill Autologous Keratinocytes"],"prefix":"10.1093","volume":"184","author":[{"given":"Davide","family":"Pennino","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Scarponi","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Carbone","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Division of Environmental Dermatology and Allergy, Zentrum Allergie und Umwelt, Helmholtz\/Technische Universitat Munchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Nasorri","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Garcovich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Universit\u00e0 Cattolica Sacro Cuore, Policlinico Gemelli , Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Traidl-Hoffmann","sequence":"additional","affiliation":[{"name":"Division of Environmental Dermatology and Allergy, Zentrum Allergie und Umwelt, Helmholtz\/Technische Universitat Munchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Albanesi","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cavani","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"2026012808082797400_r1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/ACI.0b013e3282ef6923","article-title":"New aspects of the molecular basis of contact allergy.","volume":"7","author":"Cavani","year":"2007","journal-title":"Curr. 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