{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:39:47Z","timestamp":1790739587519,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T00:00:00Z","timestamp":1260748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b3\u03b4 T lymphocytes are attractive effector cells for immunotherapy. In vitro, they can be expanded and kill efficiently a variety of tumor cells. The frequency and distribution of \u03b3\u03b4 T lymphocytes were compared in tumor lymph nodes of 51 patients with follicular lymphoma lymph nodes (FL-LNs) and 28 patients with inflammatory lymph nodes (I-LNs). \u03b3\u03b4 and CD8 T lymphocytes were less abundant in FL-LNs than in I-LNs (p \u2264 10\u22127). These lymphocytes were localized in the perifollicular zone outside of the tumor follicles. Perifollicular \u03b3\u03b4 T lymphocytes expressed CCR7, in contrast to peripheral blood \u03b3\u03b4 T lymphocytes and both perifollicular and peripheral blood \u03b3\u03b4 T lymphocytes expressed CXCR4. The very low number of perifollicular \u03b3\u03b4 T lymphocytes in FL-LNs could be explained in part by migratory problems because of absence of CCL19 expression in FL-LNs compared with I-LNs. Conversely, CCL21 and CXCL12 were similarly expressed in both FL-LNs and I-LNs. CCL19 and CCL21 were expressed in high endothelial venules and lymphatic vessels, whereas CXCL12 was expressed by stromal cells surrounding high endothelial venules and lymphatic vessels. Peripheral \u03b3\u03b4 T lymphocytes from 34 patients with FL, expanded with Phosphostim and IL-2 in vitro, had the same expansion capacity as those from healthy individuals. Thus, \u03b3\u03b4 T lymphocytes can be an attractive source for adoptive immunotherapy in patients with FL, providing they may home in tumor LNs.<\/jats:p>","DOI":"10.4049\/jimmunol.0901980","type":"journal-article","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T22:38:26Z","timestamp":1259620706000},"page":"134-140","source":"Crossref","is-referenced-by-count":18,"title":["\u03b3\u03b4 T Lymphocytes Count Is Normal and Expandable in Peripheral Blood of Patients with Follicular Lymphoma, Whereas It Is Decreased in Tumor Lymph Nodes Compared with Inflammatory Lymph Nodes"],"prefix":"10.1093","volume":"184","author":[{"given":"Mounia Sabrina","family":"Braza","sequence":"first","affiliation":[{"name":"INSERM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Caraux","sequence":"additional","affiliation":[{"name":"INSERM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8se","family":"Rousset","sequence":"additional","affiliation":[{"name":"CHU Montpellier, Centre Hospitalier Universitaire de Montpellier, Department of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lafaye de Micheaux","sequence":"additional","affiliation":[{"name":"Innate Pharma , Marseille, 13009,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Sicard","sequence":"additional","affiliation":[{"name":"Innate Pharma , Marseille, 13009,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Squiban","sequence":"additional","affiliation":[{"name":"Innate Pharma , Marseille, 13009,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Costes","sequence":"additional","affiliation":[{"name":"INSERM"},{"name":"CHU Montpellier, Centre Hospitalier Universitaire de Montpellier, Department of Pathology"},{"name":"Universit\u00e9 Montpellier1, UFR M\u00e9decine, Unit\u00e9 de Formation et de Recherche M\u00e9decine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Klein","sequence":"additional","affiliation":[{"name":"INSERM"},{"name":"Universit\u00e9 Montpellier1, UFR M\u00e9decine, Unit\u00e9 de Formation et de Recherche M\u00e9decine"},{"name":"CHU Montpellier, Centre Hospitalier Universitaire de Montpellier, Institute of Research in Biotherapy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Rossi","sequence":"additional","affiliation":[{"name":"INSERM"},{"name":"Universit\u00e9 Montpellier1, UFR M\u00e9decine, Unit\u00e9 de Formation et de Recherche M\u00e9decine"},{"name":"CHU Montpellier, Centre Hospitalier Universitaire de Montpellier, CIC BT, Centre d\u2019Investigation Clinique Bioth\u00e9rapie 509 , Montpellier, Cedex 5"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,14]]},"reference":[{"key":"2026012805023001800_r1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJM198211113072002","article-title":"Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin\u2019s lymphoma.","volume":"307","author":"Yunis","year":"1982","journal-title":"N. 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