{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:10Z","timestamp":1791405190672,"version":"4.3.3"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Allergic contact dermatitis, caused by metallic ions, is a T cell-mediated inflammatory skin disease. IL-12 is a 70-kDa heterodimeric protein composed of IL-12p40 and IL-12p35, playing a major role in the generation of allergen-specific T cell responses. Dendritic cells (DCs) are APCs involved in the induction of primary immune responses, as they possess the ability to stimulate naive T cells. In this study, we address the question whether the sensitizer nickel sulfate (NiSO4) itself or in synergy with other signals can induce the secretion of IL-12p70 in human monocyte-derived DCs (Mo-DCs). We found that IL-12p40 was produced by Mo-DC in response to NiSO4 stimulation. Addition of IFN-\u03b3 concomitantly to NiSO4 leads to IL-12p70 synthesis. NiSO4 treatment leads to the activation of MAPK, NF-\u03baB pathways, and IFN regulatory factor 1 (IRF-1). We investigated the role of these signaling pathways in IL-12 production using known pharmacological inhibitors of MAPK and NF-\u03baB pathways and RNA interference-mediated silencing of IRF-1. Our results showed that p38 MAPK, NF-\u03baB, and IRF-1 were involved in IL-12p40 production induced by NiSO4. Moreover, IRF-1 silencing nearly totally abrogated IL-12p40 and IL-12p70 production provoked by NiSO4 and IFN-\u03b3. In response to NiSO4, we observed that STAT-1 was phosphorylated on both serine and tyrosine residues and participated to NiSO4-induced IRF-1 activation. N-acetylcysteine abolished STAT-1 phosphorylation, suggesting that STAT-1 activation may be dependent on NiSO4-induced alteration of the redox status of the cell. These results indicate that p38 MAPK, NF-\u03baB, and IRF-1 are activated by NiSO4 in Mo-DC and cooperate for IL-12 production.<\/jats:p>","DOI":"10.4049\/jimmunol.0901992","type":"journal-article","created":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T02:41:27Z","timestamp":1275705687000},"page":"89-98","source":"Crossref","is-referenced-by-count":52,"title":["Mechanisms of IL-12 Synthesis by Human Dendritic Cells Treated with the Chemical Sensitizer NiSO4"],"prefix":"10.1093","volume":"185","author":[{"given":"Diane","family":"Antonios","sequence":"first","affiliation":[{"name":"Universud, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche S 749 and 996, Facult\u00e9 de Pharmacie , Ch\u00e2tenay-Malabry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Universud, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche S 749 and 996, Facult\u00e9 de Pharmacie , Ch\u00e2tenay-Malabry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Larang\u00e9","sequence":"additional","affiliation":[{"name":"Universud, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche S 749 and 996, Facult\u00e9 de Pharmacie , Ch\u00e2tenay-Malabry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Kerdine-R\u00f6mer","sequence":"additional","affiliation":[{"name":"Universud, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche S 749 and 996, Facult\u00e9 de Pharmacie , Ch\u00e2tenay-Malabry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pallardy","sequence":"additional","affiliation":[{"name":"Universud, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche S 749 and 996, Facult\u00e9 de Pharmacie , Ch\u00e2tenay-Malabry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"2025032411380361900_r1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2174\/187152808785748146","article-title":"Metal allergens of growing significance: epidemiology, immunotoxicology, strategies for testing and prevention","volume":"7","author":"Forte","year":"2008","journal-title":"Inflamm. 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