{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:36:40Z","timestamp":1790073400366,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alternatively activated macrophages prevent lethal intestinal pathology caused by worm ova in mice infected with the human parasite Schistosoma mansoni through mechanisms that are currently unclear. This study demonstrates that arginase I (Arg I), a major product of IL-4\u2013 and IL-13\u2013induced alternatively activated macrophages, prevents cachexia, neutrophilia, and endotoxemia during acute schistosomiasis. Specifically, Arg I-positive macrophages promote TGF-\u03b2 production and Foxp3 expression, suppress Ag-specific T cell proliferation, and limit Th17 differentiation. S. mansoni-infected Arg I-deficient bone marrow chimeras develop a marked accumulation of worm ova within the ileum but impaired fecal egg excretion compared with infected wild-type bone marrow chimeras. Worm ova accumulation in the intestines of Arg I-deficient bone marrow chimeras was associated with intestinal hemorrhage and production of molecules associated with classical macrophage activation (increased production of IL-6, NO, and IL-12\/IL-23p40), but whereas inhibition of NO synthase-2 has marginal effects, IL-12\/IL-23p40 neutralization abrogates both cachexia and intestinal inflammation and reduces the number of ova within the gut. Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12\/IL-23p40 production and maintaining the Treg\/Th17 balance within the intestinal mucosa.<\/jats:p>","DOI":"10.4049\/jimmunol.0902009","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T22:53:56Z","timestamp":1273100036000},"page":"6438-6446","source":"Crossref","is-referenced-by-count":107,"title":["Arginase I Suppresses IL-12\/IL-23p40\u2013Driven Intestinal Inflammation during Acute Schistosomiasis"],"prefix":"10.1093","volume":"184","author":[{"given":"De\u2019Broski R","family":"Herbert","sequence":"first","affiliation":[{"name":"Research Service, Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Orekov","sequence":"additional","affiliation":[{"name":"Research Service, Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Roloson","sequence":"additional","affiliation":[{"name":"Research Service, Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Ilies","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Perkins","sequence":"additional","affiliation":[{"name":"Research Service, Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Cederbaum","sequence":"additional","affiliation":[{"name":"Mental Retardation Research Center, University of California Los Angeles , Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Christianson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nives","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred D","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Research Service, Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"},{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"key":"2026012806290640900_r1","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.4049\/jimmunol.167.11.6078","article-title":"Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites.","volume":"167","author":"Urban","year":"2001","journal-title":"J. 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