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In this study, we show that modest differences in the number of memory CD8 T cells formed in aged versus young animals were associated with altered memory CD8 T cell differentiation. Aged immune mice had increased morbidity and mortality upon secondary viral challenge, suggesting changes in T cell immunity. Indeed, virus-specific memory CD8 T cells from aged mice showed substantially reduced proliferative expansion upon secondary infection using multiple challenge models. In addition, this defect in recall capacity of aged memory CD8 T cells was cell-intrinsic and persisted upon adoptive transfer into young mice. Thus, the poor proliferative potential of memory T cells and altered memory CD8 T cell differentiation could underlie age-related defects in antiviral immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.0902063","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T20:45:03Z","timestamp":1270500303000},"page":"5151-5159","source":"Crossref","is-referenced-by-count":63,"title":["Cell-Intrinsic Defects in the Proliferative Response of Antiviral Memory CD8 T Cells in Aged Mice upon Secondary Infection"],"prefix":"10.1093","volume":"184","author":[{"given":"Vilma","family":"Decman","sequence":"first","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J","family":"Laidlaw","sequence":"additional","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren J","family":"DiMenna","sequence":"additional","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna","family":"Mozdzanowska","sequence":"additional","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Erikson","sequence":"additional","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildegund C J","family":"Ertl","sequence":"additional","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E John","family":"Wherry","sequence":"additional","affiliation":[{"name":"Immunology Program, The Wistar Institute , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"2026012808082441800_r1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.exger.2006.09.005","article-title":"Immunity and ageing in man.","volume":"41","author":"Pawelec","year":"2006","journal-title":"Exp. 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