{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:52:04Z","timestamp":1791298324447,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institutes of Health, National Institute of Allergy and Infectious Diseases","award":["AI 063302"],"award-info":[{"award-number":["AI 063302"]}]},{"name":"National Institutes of Health, National Institute of Allergy and Infectious Diseases","award":["AI065359"],"award-info":[{"award-number":["AI065359"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PO1 AI 56320"],"award-info":[{"award-number":["PO1 AI 56320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The multiplex analysis was possible thanks to the Regional Center of Excellence","award":["AI065359"],"award-info":[{"award-number":["AI065359"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recognition of intracellular bacteria by macrophages leads to secretion of type I IFNs. However, the role of type I IFN during bacterial infection is still poorly understood. Francisella tularensis, the causative agent of tularemia, is a pathogenic bacterium that replicates in the cytosol of macrophages leading to secretion of type I IFN. In this study, we investigated the role of type I IFNs in a mouse model of tularemia. Mice deficient for type I IFN receptor (IFNAR1\u2212\/\u2212) are more resistant to intradermal infection with F. tularensis subspecies novicida (F. novicida). Increased resistance to infection was associated with a specific increase in IL-17A\/F and a corresponding expansion of an IL-17A+ \u03b3\u03b4 T cell population, indicating that type I IFNs negatively regulate the number of IL-17A+ \u03b3\u03b4 T cells during infection. Furthermore, IL-17A\u2013deficient mice contained fewer neutrophils compared with wild-type mice during infection, indicating that IL-17A contributes to neutrophil expansion during F. novicida infection. Accordingly, an increase in IL-17A in IFNAR1\u2212\/\u2212 mice correlated with an increase in splenic neutrophil numbers. Similar results were obtained in a mouse model of pneumonic tularemia using the highly virulent F. tularensis subspecies tularensis SchuS4 strain and in a mouse model of systemic Listeria monocytogenes infection. Our results indicate that the type I IFN-mediated negative regulation of IL-17A+ \u03b3\u03b4 T cell expansion is conserved during bacterial infections. We propose that this newly described activity of type I IFN signaling might participate in the resistance of the IFNAR1\u2212\/\u2212 mice to infection with F. novicida and other intracellular bacteria.<\/jats:p>","DOI":"10.4049\/jimmunol.0902065","type":"journal-article","created":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T21:35:12Z","timestamp":1266874512000},"page":"3755-3767","source":"Crossref","is-referenced-by-count":149,"title":["Type I IFN Signaling Constrains IL-17A\/F Secretion by \u03b3\u03b4 T Cells during Bacterial Infections"],"prefix":"10.1093","volume":"184","author":[{"given":"Thomas","family":"Henry","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology"},{"name":"Fondation Innovation en Infectiologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 851, Centre d\u2019infectiologie, Universit\u00e9 Lyon 1 , IFR128, Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish S","family":"Kirimanjeswara","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ruby","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitian","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Perret","sequence":"additional","affiliation":[{"name":"Fondation Innovation en Infectiologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 851, Centre d\u2019infectiologie, Universit\u00e9 Lyon 1 , IFR128, Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Demian","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California , Berkeley, CA 94117"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute of Medical Science, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W","family":"Metzger","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M","family":"Monack","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"2026012806325525500_r1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1098\/rspb.1957.0048","article-title":"Virus interference. I. The interferon.","volume":"147","author":"Isaacs","year":"1957","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"2026012806325525500_r2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","article-title":"Interferons, interferon-like cytokines, and their receptors.","volume":"202","author":"Pestka","year":"2004","journal-title":"Immunol. Rev."},{"key":"2026012806325525500_r3","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1128\/IAI.68.3.1600-1607.2000","article-title":"Bacterial induction of beta interferon in mice is a function of the lipopolysaccharide component.","volume":"68","author":"Sing","year":"2000","journal-title":"Infect. Immun."},{"key":"2026012806325525500_r4","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ni774","article-title":"TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha\/beta-dependent gene expression in macrophages.","volume":"3","author":"Toshchakov","year":"2002","journal-title":"Nat. Immunol."},{"key":"2026012806325525500_r5","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ni.1733","article-title":"Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells.","volume":"10","author":"Mancuso","year":"2009","journal-title":"Nat. Immunol."},{"key":"2026012806325525500_r6","doi-asserted-by":"crossref","first-page":"13861","DOI":"10.1073\/pnas.202476699","article-title":"Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.","volume":"99","author":"O\u2019Riordan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026012806325525500_r7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1084\/jem.20062665","article-title":"Type I interferon signaling is required for activation of the inflammasome during Francisella infection.","volume":"204","author":"Henry","year":"2007","journal-title":"J. Exp. Med."},{"key":"2026012806325525500_r8","doi-asserted-by":"crossref","first-page":"36173","DOI":"10.1074\/jbc.M604638200","article-title":"Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.","volume":"281","author":"Opitz","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2026012806325525500_r9","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.4049\/jimmunol.178.5.3143","article-title":"The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis.","volume":"178","author":"Stanley","year":"2007","journal-title":"J. Immunol."},{"key":"2026012806325525500_r10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.chom.2008.11.002","article-title":"TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.","volume":"4","author":"Charrel-Dennis","year":"2008","journal-title":"Cell Host Microbe"},{"key":"2026012806325525500_r11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2005.12.003","article-title":"Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.","volume":"24","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"2026012806325525500_r12","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1371\/journal.ppat.0040006","article-title":"Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.","volume":"4","author":"Leber","year":"2008","journal-title":"PLoS Pathog."},{"key":"2026012806325525500_r13","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1128\/IAI.01868-06","article-title":"Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages.","volume":"75","author":"Cole","year":"2007","journal-title":"Infect. Immun."},{"key":"2026012806325525500_r14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1084\/jem.20060045","article-title":"Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.","volume":"203","author":"Carrero","year":"2006","journal-title":"J. Exp. Med."},{"key":"2026012806325525500_r15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.","volume":"200","author":"Auerbuch","year":"2004","journal-title":"J. Exp. Med."},{"key":"2026012806325525500_r16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection.","volume":"200","author":"O\u2019Connell","year":"2004","journal-title":"J. Exp. Med."},{"key":"2026012806325525500_r17","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1128\/IAI.00629-08","article-title":"Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model.","volume":"76","author":"Nagarajan","year":"2008","journal-title":"Infect. Immun."},{"key":"2026012806325525500_r18","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.4049\/jimmunol.181.3.2092","article-title":"Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages.","volume":"181","author":"Qiu","year":"2008","journal-title":"J. Immunol."},{"key":"2026012806325525500_r19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.it.2006.09.005","article-title":"Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens.","volume":"27","author":"Carrero","year":"2006","journal-title":"Trends Immunol."},{"key":"2026012806325525500_r20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1196\/annals.1409.011","article-title":"Molecular epidemiology, evolution, and ecology of Francisella.","volume":"1105","author":"Keim","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2026012806325525500_r21","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.1128\/IAI.00934-06","article-title":"Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors.","volume":"74","author":"Hajjar","year":"2006","journal-title":"Infect. Immun."},{"key":"2026012806325525500_r22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1074-7613(02)00391-6","article-title":"Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.","volume":"17","author":"Nakae","year":"2002","journal-title":"Immunity"},{"key":"2026012806325525500_r23","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1128\/IAI.01250-06","article-title":"Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis.","volume":"74","author":"Brotcke","year":"2006","journal-title":"Infect. Immun."},{"key":"2026012806325525500_r24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/cyto.b.20452","article-title":"A comparison of multiplex suspension array large-panel kits for profiling cytokines and chemokines in rheumatoid arthritis patients.","volume":"76","author":"Khan","year":"2009","journal-title":"Cytometry B Clin. Cytom."},{"key":"2026012806325525500_r25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20040769","article-title":"Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.","volume":"200","author":"Carrero","year":"2004","journal-title":"J. Exp. Med."},{"key":"2026012806325525500_r26","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1073\/pnas.94.2.634","article-title":"Interferon-alpha\/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection.","volume":"94","author":"Cousens","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026012806325525500_r27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","article-title":"The roles of IL-17A in inflammatory immune responses and host defense against pathogens.","volume":"226","author":"Iwakura","year":"2008","journal-title":"Immunol. Rev."},{"key":"2026012806325525500_r28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","article-title":"Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.","volume":"30","author":"Ishigame","year":"2009","journal-title":"Immunity"},{"key":"2026012806325525500_r29","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1128\/IAI.00514-08","article-title":"Diverse myeloid and lymphoid cell subpopulations produce gamma interferon during early innate immune responses to Francisella tularensis live vaccine strain.","volume":"76","author":"De Pascalis","year":"2008","journal-title":"Infect. Immun."},{"key":"2026012806325525500_r30","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1128\/IAI.01412-07","article-title":"Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells.","volume":"76","author":"Woolard","year":"2008","journal-title":"Infect. Immun."},{"key":"2026012806325525500_r31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ni.1717","article-title":"CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat. Immunol."},{"key":"2026012806325525500_r32","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.4049\/jimmunol.181.5.3456","article-title":"IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver.","volume":"181","author":"Hamada","year":"2008","journal-title":"J. Immunol."},{"key":"2026012806325525500_r33","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.4049\/jimmunol.174.10.5936","article-title":"Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections.","volume":"174","author":"Liu","year":"2005","journal-title":"J. Immunol."},{"key":"2026012806325525500_r34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni1375","article-title":"Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.","volume":"7","author":"Batten","year":"2006","journal-title":"Nat. Immunol."},{"key":"2026012806325525500_r35","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni1376","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.","volume":"7","author":"Stumhofer","year":"2006","journal-title":"Nat. Immunol."},{"key":"2026012806325525500_r36","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1172\/JCI33342","article-title":"The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.","volume":"118","author":"Guo","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2026012806325525500_r37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.coi.2009.03.013","article-title":"The Current STATus of lymphocyte signaling: new roles for old players.","volume":"21","author":"Adamson","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"2026012806325525500_r38","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 family cytokines and the expanding diversity of effector T cell lineages.","volume":"25","author":"Weaver","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"2026012806325525500_r39","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1196\/annals.1409.007","article-title":"Mucosal Immunopathogenesis of Francisella tularensis.","volume":"1105","author":"Metzger","year":"2007","journal-title":"Ann NY Acad Sci %R"},{"key":"2026012806325525500_r40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation.","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"2026012806325525500_r41","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.coi.2008.03.006","article-title":"gammadelta T cells: an important source of IL-17.","volume":"20","author":"Roark","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"2026012806325525500_r42","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.4049\/jimmunol.178.6.3786","article-title":"IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection.","volume":"178","author":"Umemura","year":"2007","journal-title":"J. Immunol."},{"key":"2026012806325525500_r43","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/intimm\/dxn069","article-title":"IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance.","volume":"20","author":"Schulz","year":"2008","journal-title":"Int. Immunol."},{"key":"2026012806325525500_r44","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.4049\/jimmunol.172.8.4866","article-title":"Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule.","volume":"172","author":"Carrero","year":"2004","journal-title":"J. Immunol."},{"key":"2026012806325525500_r45","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.4049\/jimmunol.0803039","article-title":"IL-17 receptor signaling is required to control polymicrobial sepsis.","volume":"182","author":"Freitas","year":"2009","journal-title":"J. Immunol."},{"key":"2026012806325525500_r46","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.194.4.519","article-title":"Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense.","volume":"194","author":"Ye","year":"2001","journal-title":"J. Exp. Med."},{"key":"2026012806325525500_r47","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.4049\/jimmunol.178.7.4466","article-title":"Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.","volume":"178","author":"Shibata","year":"2007","journal-title":"J. Immunol."},{"key":"2026012806325525500_r48","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.4049\/jimmunol.170.10.5228","article-title":"Neutrophilia in LFA-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony-stimulating factor and IL-17.","volume":"170","author":"Miyamoto","year":"2003","journal-title":"J. Immunol."},{"key":"2026012806325525500_r49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0171-2985(99)80057-6","article-title":"Early host-pathogen interactions in the liver and spleen during systemic murine listeriosis: an overview.","volume":"201","author":"Conlan","year":"1999","journal-title":"Immunobiology"},{"key":"2026012806325525500_r50","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-065X.2008.00689.x","article-title":"Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis.","volume":"225","author":"Kirimanjeswara","year":"2008","journal-title":"Immunol. Rev."},{"key":"2026012806325525500_r51","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.immuni.2009.02.007","article-title":"Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.","volume":"30","author":"Chung","year":"2009","journal-title":"Immunity"},{"key":"2026012806325525500_r52","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/eji.200838331","article-title":"Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells.","volume":"38","author":"Gu","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"2026012806325525500_r53","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/7\/3755\/62722699\/ji_0902065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/7\/3755\/62722699\/ji_0902065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:36:56Z","timestamp":1769600216000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/7\/3755\/8007264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,4,1]]},"published-print":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0902065","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,4]]},"published":{"date-parts":[[2010,4,1]]}}}