{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:05:24Z","timestamp":1761843924710,"version":"3.40.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>TNF has been shown to be important for controlling many pathogens. Here, we directly demonstrate using wild-type TNF\u2212\/\u2212 and TNFR1\u2212\/\u2212 mice that TNF does play a role in protection against vaccinia virus (VV) infection in naive mice. Since VV replication is also partially controlled in lymphocytic choriomeningitis virus (LCMV)-immune C57BL\/6J mice through the process of heterologous immunity, we questioned whether TNF was required in mediating this protection. VV-infected LCMV-immune mice that were TNF-deficient as a consequence of genetic deletion or receptor blockade demonstrated normal recruitment and selective expansion of cross-reactive LCMV-specific memory CD8 T cells and controlled VV infection similar to LCMV-immune mice having TNF function. This indicates that neither TNF nor lymphotoxin, which uses the same receptor, was required in mediating protective heterologous immunity against VV. Indeed, prior immunity to LCMV made the role of TNF in protection against VV infection much less important, even under conditions of lethal dose inoculum. Thus, heterologous immunity may help explain why treatment of patients with anti-TNF compounds is reasonably well tolerated with relatively few infectious complications.<\/jats:p>","DOI":"10.4049\/jimmunol.0902156","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T02:25:49Z","timestamp":1256178349000},"page":"6554-6560","source":"Crossref","is-referenced-by-count":11,"title":["Resistance to Vaccinia Virus Is Less Dependent on TNF under Conditions of Heterologous Immunity"],"prefix":"10.1093","volume":"183","author":[{"given":"Siwei","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School , Worcester, MA 01655"},{"name":"Dept. of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa K","family":"Selin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,11,15]]},"reference":[{"key":"2025032603213049500_R1","first-page":"241","article-title":"Tumor necrosis factor (TNF)-\u03b1 and TNF receptors in viral pathogenesis.","volume-title":"Proc. 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