{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:46:37Z","timestamp":1792572397306,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T00:00:00Z","timestamp":1262131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB587-B3"],"award-info":[{"award-number":["SFB587-B3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dendritic cells (DCs) residing in the lung are known to acquire inhaled Ag and, after migration to the draining bronchial lymph node (brLN), to present it to naive T cells in an either tolerogenic or immunogenic context. To visualize endogenous lung-derived DCs, we applied fluorescent latex beads (LXs) intratracheally, thereby in vivo labeling the majority of phagocytic cells within the lung. Of note, LX-bearing cells subsequently arriving in the draining brLN were found to represent lung-derived migratory DCs. Imaging explanted brLN by two-photon laser-scanning microscopy, we quantitatively analyzed the migration and interaction behavior of naive CD4+ T cells and endogenous, lung-derived DC presenting airway-delivered Ag under inflammatory or noninflammatory conditions. Ag-specific naive CD4+ T cells engaged in stable as well as transient contacts with LX-bearing DCs in both situations and displayed similar overall motility kinetics, including a pronounced decrease in motility at 16\u201320 h after antigenic challenge. In contrast, the comparative analysis of T cell\u2013DC cluster sizes as well as contact durations strongly suggests that lung-derived migratory DCs and naive CD4+ T cells form more stable, long-lasting contacts under inflammatory conditions favoring the induction of respiratory immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.0902277","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T22:01:23Z","timestamp":1262210483000},"page":"1317-1327","source":"Crossref","is-referenced-by-count":23,"title":["T Cell\u2013Dendritic Cell Interaction Dynamics during the Induction of Respiratory Tolerance and Immunity"],"prefix":"10.1093","volume":"184","author":[{"given":"Nadja","family":"Bako\u010devi\u0107","sequence":"first","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Worbs","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Davalos-Misslitz","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,30]]},"reference":[{"key":"2026012808084233800_r1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1136\/bmj.330.7499.1037","article-title":"Prevalence of asthma.","volume":"330","author":"Anderson","year":"2005","journal-title":"BMJ"},{"key":"2026012808084233800_r2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev.immunol.21.120601.141040","article-title":"Tolerogenic dendritic cells.","volume":"21","author":"Steinman","year":"2003","journal-title":"Annu. 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