{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:08:45Z","timestamp":1769645325612,"version":"3.49.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutrophilic asthma is a prevalent, yet recently described phenotype of asthma. It is characterized by neutrophilic rather than eosinophilic airway inflammation and airways hyperresponsiveness (AHR) and may have an infectious origin. Chlamydial respiratory infections are associated with asthma, but how these Th1-inducing bacteria influence Th2-mediated asthma remains unknown. The effects of chlamydial infection on the development of asthma were investigated using a BALB\/c mouse model of OVA-induced allergic airways disease (AAD). The effects of current and resolved Chlamydia muridarum infection during OVA sensitization on AAD were assessed and compared with uninfected and nonsensitized controls. Current, but not resolved, infection attenuated hallmark features of AAD: pulmonary eosinophil influx, T cell production of IL-5, mucus-secreting cell hyperplasia, and AHR. Current infection also induced robust OVA-driven neutrophilic inflammation and IFN-\u03b3 release from T cells. The phenotype of suppressed but persistent Th2 responses in association with enhanced neutrophilia is reminiscent of neutrophilic asthma. This phenotype was also characterized by increased pulmonary IL-12 and IL-17 expression and activation of APCs, as well as by reduced thymus- and activation-regulated chemokine. Inhibition of pulmonary neutrophil influx during infection blocked OVA-induced neutrophilic inflammation and T cell IFN-\u03b3 production and reversed the suppressive effects on mucus-secreting cell hyperplasia and AHR during AAD. These changes correlated with decreased IL-12 and IL-17 expression, increased thymus- and activation-regulated chemokine and altered APC activation. Blocking IFN-\u03b3 and IL-17 during OVA challenge had no effect. Thus, active chlamydial respiratory infection during sensitization enhances subsequent neutrophilic inflammation and Th1\/Th17 responses during allergen exposure and may have a role in the pathogenesis of neutrophilic asthma.<\/jats:p>","DOI":"10.4049\/jimmunol.0902287","type":"journal-article","created":{"date-parts":[[2010,3,12]],"date-time":"2010-03-12T21:10:31Z","timestamp":1268428231000},"page":"4159-4169","source":"Crossref","is-referenced-by-count":73,"title":["Chlamydial Respiratory Infection during Allergen Sensitization Drives Neutrophilic Allergic Airways Disease"],"prefix":"10.1093","volume":"184","author":[{"given":"Jay C","family":"Horvat","sequence":"first","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm R","family":"Starkey","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Y","family":"Kim","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth W","family":"Beagley","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"},{"name":"Institute of Health and Biomedical Innovation, Queensland University of Technology , Brisbane, Queensland,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A","family":"Preston","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G","family":"Gibson","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S","family":"Foster","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle , Newcastle, New South Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,4,15]]},"reference":[{"key":"2026012808074815000_r1","first-page":"95","volume-title":"Global strategy for asthma management and prevention. National Institutes of Health, National Heart, Lung, and Blood Institute.","author":"WHO\/NHLBI","year":"1995"},{"key":"2026012808074815000_r2","first-page":"97","volume-title":"NHLBI guidelines for diagnosis and management of asthma. National Institutes of Health, National Heart, Lung, and Blood Institute.","author":"Hilman","year":"1997"},{"key":"2026012808074815000_r3","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.4049\/jimmunol.160.10.4730","article-title":"Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile.","volume":"160","author":"Prescott","year":"1998","journal-title":"J. Immunol."},{"key":"2026012808074815000_r4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2567.2004.01927.x","article-title":"Reversal of established CD4+ type 2 T helper-mediated allergic airway inflammation and eosinophilia by therapeutic treatment with DNA vaccines limits progression towards chronic inflammation and remodelling.","volume":"112","author":"Jarman","year":"2004","journal-title":"Immunology"},{"key":"2026012808074815000_r5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0163-7258(02)00220-6","article-title":"Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease.","volume":"94","author":"Foster","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"2026012808074815000_r6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.coph.2004.01.011","article-title":"Airway mucus hypersecretion in asthma: an undervalued pathology?","volume":"4","author":"Rogers","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"key":"2026012808074815000_r7","doi-asserted-by":"crossref","first-page":"411S","DOI":"10.1378\/chest.123.3_suppl.411S","article-title":"Airway hyperresponsiveness.","volume":"123","author":"O\u2019Byrne","year":"2003","journal-title":"Chest"},{"key":"2026012808074815000_r8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pharmthera.2003.10.007","article-title":"Role of atypical bacterial infection of the lung in predisposition\/protection of asthma.","volume":"101","author":"Hansbro","year":"2004","journal-title":"Pharmacol. Ther."},{"key":"2026012808074815000_r9","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1164\/rccm.200607-1005OC","article-title":"Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease.","volume":"176","author":"Horvat","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026012808074815000_r10","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.156.11.4338","article-title":"Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection.","volume":"156","author":"Yang","year":"1996","journal-title":"J. Immunol."},{"key":"2026012808074815000_r11","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.4049\/jimmunol.162.2.1010","article-title":"IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection.","volume":"162","author":"Yang","year":"1999","journal-title":"J. Immunol."},{"key":"2026012808074815000_r12","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1378\/chest.119.5.1329","article-title":"Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8.","volume":"119","author":"Gibson","year":"2001","journal-title":"Chest"},{"key":"2026012808074815000_r13","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1164\/ajrccm.160.3.9812110","article-title":"Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics.","volume":"160","author":"Wenzel","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026012808074815000_r14","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/ajrccm.161.4.9812061","article-title":"Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.","volume":"161","author":"Ordo\u00f1ez","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026012808074815000_r15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1440-1843.2006.00784.x","article-title":"Inflammatory subtypes in asthma: assessment and identification using induced sputum.","volume":"11","author":"Simpson","year":"2006","journal-title":"Respirology"},{"key":"2026012808074815000_r16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/thx.2006.061358","article-title":"Innate immune activation in neutrophilic asthma and bronchiectasis.","volume":"62","author":"Simpson","year":"2007","journal-title":"Thorax"},{"key":"2026012808074815000_r17","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1378\/chest.07-1881","article-title":"Differences in airway cytokine profile in severe asthma compared to moderate asthma.","volume":"133","author":"Shannon","year":"2008","journal-title":"Chest"},{"key":"2026012808074815000_r18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1183\/09031936.02.00226302","article-title":"Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma.","volume":"19","author":"Wark","year":"2002","journal-title":"Eur. Respir. J."},{"key":"2026012808074815000_r19","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1183\/09031936.02.00192002","article-title":"Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma.","volume":"20","author":"Wark","year":"2002","journal-title":"Eur. Respir. J."},{"key":"2026012808074815000_r20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2567.2004.02088.x","article-title":"Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent induces significant neutrophil infiltration which is not efficient in controlling the infection in mice.","volume":"114","author":"Bai","year":"2005","journal-title":"Immunology"},{"key":"2026012808074815000_r21","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.4049\/jimmunol.174.8.4836","article-title":"Polymorphonuclear neutrophils improve replication of Chlamydia pneumoniae in vivo upon MyD88-dependent attraction.","volume":"174","author":"Rodriguez","year":"2005","journal-title":"J. Immunol."},{"key":"2026012808074815000_r22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/clim.2001.5144","article-title":"Chlamydia trachomatis infection inhibits airway eosinophilic inflammation induced by ragweed.","volume":"102","author":"Bilenki","year":"2002","journal-title":"Clin. Immunol."},{"key":"2026012808074815000_r23","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.4049\/jimmunol.180.7.4621","article-title":"NK cells contribute to intracellular bacterial infection-mediated inhibition of allergic responses.","volume":"180","author":"Han","year":"2008","journal-title":"J. Immunol."},{"key":"2026012808074815000_r24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/187152807780832210","article-title":"Measuring T cell cytokines in allergic upper and lower airway inflammation: can we move to the clinic?","volume":"6","author":"Bullens","year":"2007","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"2026012808074815000_r25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2174\/187152806779010909","article-title":"Interferon-\u03b3 as a possible target in chronic asthma.","volume":"5","author":"Kumar","year":"2006","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"2026012808074815000_r26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/thx.2005.052399","article-title":"Evaluation of airway inflammation by quantitative Th1\/Th2 cytokine mRNA measurement in sputum of asthma patients.","volume":"61","author":"Truyen","year":"2006","journal-title":"Thorax"},{"key":"2026012808074815000_r27","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1164\/rccm.200312-1659OC","article-title":"Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma.","volume":"169","author":"Liu","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026012808074815000_r28","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.4049\/jimmunol.167.3.1683","article-title":"IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung.","volume":"167","author":"Mattes","year":"2001","journal-title":"J. Immunol."},{"key":"2026012808074815000_r29","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1128\/iai.61.8.3556-3558.1993","article-title":"Gamma interferon levels during Chlamydia trachomatis pneumonia in mice.","volume":"61","author":"Williams","year":"1993","journal-title":"Infect. Immun."},{"key":"2026012808074815000_r30","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1182\/blood-2007-01-071340","article-title":"Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus.","volume":"110","author":"Phipps","year":"2007","journal-title":"Blood"},{"key":"2026012808074815000_r31","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/ni.1637","article-title":"A critical function for CD200 in lung immune homeostasis and the severity of influenza infection.","volume":"9","author":"Snelgrove","year":"2008","journal-title":"Nat. Immunol."},{"key":"2026012808074815000_r32","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.4049\/jimmunol.162.4.2217","article-title":"IL-12 administered during Chlamydia psittaci lung infection in mice confers immediate and long-term protection and reduces macrophage inflammatory protein-2 level and neutrophil infiltration in lung tissue.","volume":"162","author":"Huang","year":"1999","journal-title":"J. Immunol."},{"key":"2026012808074815000_r33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.79.5.497","article-title":"Isolation from normal mice of a pneumotropic virus which forms elementary bodies.","volume":"79","author":"Nigg","year":"1944","journal-title":"J. Exp. Med."},{"key":"2026012808074815000_r34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/infdis\/92.3.254","article-title":"The histopathology of murine pneumonitis infection and the growth of the virus in the mouse lung.","volume":"92","author":"Gogolak","year":"1953","journal-title":"J. Infect. Dis."},{"key":"2026012808074815000_r35","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0091-6749(95)70128-1","article-title":"Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation.","volume":"95","author":"Fahy","year":"1995","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026012808074815000_r36","first-page":"713","article-title":"Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?","volume":"148","author":"Sur","year":"1993","journal-title":"Am Rev Respir Res"},{"key":"2026012808074815000_r37","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jaci.2005.06.003","article-title":"The role of rhinovirus in asthma exacerbations.","volume":"116","author":"Friedlander","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026012808074815000_r38","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1067\/mai.2001.113047","article-title":"Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection.","volume":"107","author":"ten Brinke","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026012808074815000_r39","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/thx.53.12.1094c","article-title":"Chlamydia pneumoniae and asthma.","volume":"53","author":"Hahn","year":"1998","journal-title":"Thorax"},{"key":"2026012808074815000_r40","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.4049\/jimmunol.172.3.1768","article-title":"Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis.","volume":"172","author":"van Zandbergen","year":"2004","journal-title":"J. Immunol."},{"key":"2026012808074815000_r41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1165\/rcmb.4832","article-title":"Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.","volume":"28","author":"Hellings","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026012808074815000_r42","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1084\/jem.177.4.1199","article-title":"Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.","volume":"177","author":"Manetti","year":"1993","journal-title":"J. Exp. Med."},{"key":"2026012808074815000_r43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1183\/09031936.04.00032904","article-title":"Neutrophils, interleukin-17A and lung disease.","volume":"25","author":"Lind\u00e9n","year":"2005","journal-title":"Eur. Respir. J."},{"key":"2026012808074815000_r44","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1067\/mai.2001.117929","article-title":"IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.","volume":"108","author":"Molet","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026012808074815000_r45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1465-9921-7-135","article-title":"IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?","volume":"7","author":"Bullens","year":"2006","journal-title":"Respir. Res."},{"key":"2026012808074815000_r46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jaci.2004.10.046","article-title":"TH1-mediated airway hyperresponsiveness independent of neutrophilic inflammation.","volume":"115","author":"Cui","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026012808074815000_r47","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.4049\/jimmunol.181.6.4089","article-title":"TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.","volume":"181","author":"McKinley","year":"2008","journal-title":"J. Immunol."},{"key":"2026012808074815000_r48","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11882-007-0071-6","article-title":"Neutrophils in asthma.","volume":"7","author":"Macdowell","year":"2007","journal-title":"Curr. Allergy Asthma Rep."},{"key":"2026012808074815000_r49","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1136\/thorax.57.10.875","article-title":"Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids.","volume":"57","author":"Green","year":"2002","journal-title":"Thorax"},{"key":"2026012808074815000_r50","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1067\/mai.2003.1612","article-title":"Effect of HFA-flunisolide on peripheral lung inflammation in asthma.","volume":"112","author":"Hauber","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026012808074815000_r51","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.4049\/jimmunol.156.11.4422","article-title":"Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes.","volume":"156","author":"Meagher","year":"1996","journal-title":"J. Immunol."},{"key":"2026012808074815000_r52","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.4049\/jimmunol.154.9.4719","article-title":"Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes.","volume":"154","author":"Cox","year":"1995","journal-title":"J. Immunol."},{"key":"2026012808074815000_r53","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1128\/jcm.34.10.2379-2381.1996","article-title":"Effect of hydrocortisone succinate on growth of Chlamydia pneumoniae in vitro.","volume":"34","author":"Tsumura","year":"1996","journal-title":"J. Clin. Microbiol."},{"key":"2026012808074815000_r54","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1128\/iai.64.4.1488-1490.1996","article-title":"Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment.","volume":"64","author":"Laitinen","year":"1996","journal-title":"Infect. Immun."},{"key":"2026012808074815000_r55","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1034\/j.1399-3003.2000.15b06.x","article-title":"Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthma.","volume":"15","author":"Black","year":"2000","journal-title":"Eur. Respir. J."},{"key":"2026012808074815000_r56","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/j.1365-2222.2005.02391.x","article-title":"Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-alpha-dependent pathway.","volume":"35","author":"Cho","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"2026012808074815000_r57","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.4049\/jimmunol.155.4.2158","article-title":"Chemokine binding and activities mediated by the mouse IL-8 receptor.","volume":"155","author":"Lee","year":"1995","journal-title":"J. Immunol."},{"key":"2026012808074815000_r58","doi-asserted-by":"crossref","first-page":"L58","DOI":"10.1152\/ajplung.2001.280.1.L58","article-title":"Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14.","volume":"280","author":"Maus","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2026012808074815000_r59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/intimm\/11.1.81","article-title":"Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.","volume":"11","author":"Imai","year":"1999","journal-title":"Int. Immunol."},{"key":"2026012808074815000_r60","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4049\/jimmunol.161.2.547","article-title":"The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells.","volume":"161","author":"Zingoni","year":"1998","journal-title":"J. Immunol."},{"key":"2026012808074815000_r61","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0092-8674(95)90349-6","article-title":"B7-1 and B7-2 costimulatory molecules activate differentially the Th1\/Th2 developmental pathways: application to autoimmune disease therapy.","volume":"80","author":"Kuchroo","year":"1995","journal-title":"Cell"},{"key":"2026012808074815000_r62","first-page":"421","article-title":"CD80 and CD86 expression on LPS-stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma.","volume":"51","author":"Rutkowski","year":"2003","journal-title":"Arch. Immunol. Ther. Exp. (Warsz.)"},{"key":"2026012808074815000_r63","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2567.2007.02802.x","article-title":"Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis.","volume":"124","author":"Odobasic","year":"2008","journal-title":"Immunology"},{"key":"2026012808074815000_r64","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1189\/jlb.0905526","article-title":"Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes.","volume":"79","author":"Megiovanni","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2026012808074815000_r65","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.4049\/jimmunol.171.11.6052","article-title":"Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection.","volume":"171","author":"Bennouna","year":"2003","journal-title":"J. Immunol."},{"key":"2026012808074815000_r66","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/eji.200636771","article-title":"Spontaneous or Mycobacterium tuberculosis-induced apoptotic neutrophils exert opposite effects on the dendritic cell-mediated immune response.","volume":"37","author":"Alem\u00e1n","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2026012808074815000_r67","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.imlet.2008.02.008","article-title":"Murine neutrophils present Class II restricted antigen.","volume":"118","author":"Culshaw","year":"2008","journal-title":"Immunol. Lett."},{"key":"2026012808074815000_r68","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1078\/0171-2985-00092","article-title":"Regulation of Th1\/Th2 development by antigen-presenting cells in vivo.","volume":"204","author":"Moser","year":"2001","journal-title":"Immunobiology"},{"key":"2026012808074815000_r69","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.4049\/jimmunol.159.4.1993","article-title":"Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines.","volume":"159","author":"Sozzani","year":"1997","journal-title":"J. Immunol."},{"key":"2026012808074815000_r70","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1128\/IAI.00403-09","article-title":"Critical role of the interleukin-17\/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.","volume":"77","author":"Zhou","year":"2009","journal-title":"Infect. Immun."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/8\/4159\/62714077\/ji_0902287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/8\/4159\/62714077\/ji_0902287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:08:09Z","timestamp":1769605689000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/8\/4159\/8013290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,4,15]]},"published-print":{"date-parts":[[2010,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0902287","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,4]]},"published":{"date-parts":[[2010,4]]}}}