{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:58:37Z","timestamp":1769835517742,"version":"3.49.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recruitment of bone marrow-derived myelomonocytic cells plays a fundamental role in tumor angiogenesis and metastasis. Placental growth factor (PlGF) is a potent cytokine that can attract myelomonocytic cells to the tumor. However, the underlying mechanism remains obscure. In this study, we demonstrate that tumor-derived PlGF activates NFAT1 via vascular endothelial growth factor receptor 1 in both murine and human myelomonocytic cells. Activation of NFAT1 is crucial for PlGF-induced myelomonocytic cell recruitment as shown by the in vitro transwell migration assay, transendothelial migration assay, and PlGF-overexpressing tumor models in mice, respectively. TNF-\u03b1 is upregulated by PlGF in myelomonocytic cells in an NFAT1-dependent manner, which in turn contributes to PlGF-induced myelomonocytic cell recruitment. Blockade of TNF-\u03b1 expression by RNA interference or neutralization of secreted TNF-\u03b1 with its Ab attenuates PlGF-induced myelomonocytic cell migration and transendothelial migration. Furthermore, the inhibitory effect of NFAT1 RNA interference on PlGF function is rescued by exogenously added TNF-\u03b1. Taken together, we demonstrate that NFAT1 mediates PlGF-induced myelomonocytic cell recruitment via the induction of TNF-\u03b1. Our present studies discover a novel role of the NFAT1\u2013TNF-\u03b1 pathway in tumor inflammation, which may provide potential targets to diversify current cancer therapy.<\/jats:p>","DOI":"10.4049\/jimmunol.0902378","type":"journal-article","created":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T22:03:29Z","timestamp":1264197809000},"page":"2593-2601","source":"Crossref","is-referenced-by-count":24,"title":["NFAT1 Mediates Placental Growth Factor-Induced Myelomonocytic Cell Recruitment via the Induction of TNF\n                    <b>-<\/b>\n                    \u03b1"],"prefix":"10.1093","volume":"184","author":[{"given":"Yanping","family":"Ding","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Huang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Song","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Gao","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaopeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchen","family":"Cai","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhang","family":"Luo","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,3,1]]},"reference":[{"key":"2026012806311345100_r1","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1158\/0008-5472.CAN-05-2714","article-title":"Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion.","volume":"65","author":"Colombo","year":"2005","journal-title":"Cancer Res."},{"key":"2026012806311345100_r2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/0008-5472.CAN-05-4005","article-title":"Distinct role 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