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The \u03b14 integrin subunit that pairs with \u03b27 integrin can also pair with \u03b21 integrin. In this paper, we show that the preferential pairing of \u03b21 integrin with \u03b14 integrin regulates the expression of \u03b14\u03b27 on T cells. In the absence of \u03b21 integrin, naive mouse CD4 T cells have increased \u03b14\u03b27 expression, resulting in increased adhesion to mucosal addressin cell adhesion molecule-1 and enhanced homing to Peyer\u2019s patches (PP). In a reciprocal manner, overexpression of \u03b21 integrin causes the loss of \u03b14\u03b27 expression and decreased homing to PP. A similar upregulation of \u03b21 integrin and suppression of \u03b14\u03b27 expression occurs rapidly after CD4 T cell activation. \u03b21 integrin thus dominates \u03b27 integrin for \u03b14 integrin pairing, thereby controlling the abundance of unpaired \u03b14 integrin. Increasing the abundance of \u03b14 integrin relative to \u03b21 integrin is critical to retinoic acid-mediated expression of \u03b14\u03b27 integrin during T cell activation. In the absence of \u03b21 integrin, endogenous Ag-specific CD4 T cells uniformly express high levels of \u03b14\u03b27 after Listeria monocytogenes infection. The resulting \u03b21-deficient early memory T cells have decreased localization to the bone marrow and enhanced localization to PP after infection. Thus, the preferential association of \u03b21 integrin with \u03b14 integrin suppresses \u03b14\u03b27 integrin expression and regulates the localization of memory CD4 T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.0902407","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T22:59:58Z","timestamp":1264805998000},"page":"2458-2467","source":"Crossref","is-referenced-by-count":78,"title":["Control of \u03b14\u03b27 Integrin Expression and CD4 T Cell Homing by the \u03b21 Integrin Subunit"],"prefix":"10.1093","volume":"184","author":[{"given":"Christopher C","family":"DeNucci","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J","family":"Pag\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,3,1]]},"reference":[{"key":"2026012806305019900_r1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines.","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"2026012806305019900_r2","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1056\/NEJM200010053431407","article-title":"T-cell function and migration. Two sides of the same coin.","volume":"343","author":"von Andrian","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"2026012806305019900_r3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevImmunol.v29.i2.10","article-title":"Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there.","volume":"29","author":"Denucci","year":"2009","journal-title":"Crit. Rev. Immunol."},{"key":"2026012806305019900_r4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4049\/jimmunol.151.2.717","article-title":"Selective expression of integrin \u03b14\u03b27 on a subset of human CD4+ memory T cells with hallmarks of gut-trophism.","volume":"151","author":"Schweighoffer","year":"1993","journal-title":"J. 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