{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:04:40Z","timestamp":1767985480807,"version":"3.49.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sj\u00f6gren\u2019s Syndrome (SS) is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. In this study, we show that the Aire-deficient mouse represents a new tool to investigate autoimmune dacryoadenitis and keratoconjunctivitis sicca, features of SS. Previous work in the Aire-deficient mouse suggested a role for \u03b1-fodrin, a ubiquitous Ag, in the disease process. Using an unbiased biochemical approach, however, we have identified a novel lacrimal gland autoantigen, odorant binding protein 1a, targeted by the autoimmune response. This novel autoantigen is expressed in the thymus in an Aire-dependent manner. The results from our study suggest that defects in central tolerance may contribute to SS and provide a new and clinically relevant model to investigate the pathogenic mechanisms in lacrimal gland autoimmunity and associated ocular surface sequelae.<\/jats:p>","DOI":"10.4049\/jimmunol.0902434","type":"journal-article","created":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T02:33:41Z","timestamp":1268879621000},"page":"4236-4246","source":"Crossref","is-referenced-by-count":41,"title":["An Autoimmune Response to Odorant Binding Protein 1a Is Associated with Dry Eye in the <i>Aire<\/i>-Deficient Mouse"],"prefix":"10.1093","volume":"184","author":[{"given":"Jason J.","family":"DeVoss","sequence":"first","affiliation":[{"name":"*Diabetes Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert P.","family":"LeClair","sequence":"additional","affiliation":[{"name":"\u2020Proctor Foundation, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Hou","sequence":"additional","affiliation":[{"name":"\u2021Department of Medicine, University of California-San Francisco, San Francisco, CA 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navdeep K.","family":"Grewal","sequence":"additional","affiliation":[{"name":"*Diabetes Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kellsey P.","family":"Johannes","sequence":"additional","affiliation":[{"name":"*Diabetes Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"*Diabetes Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"*Diabetes Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Meagher","sequence":"additional","affiliation":[{"name":"\u2020Proctor Foundation, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Fong","sequence":"additional","affiliation":[{"name":"\u2021Department of Medicine, University of California-San Francisco, San Francisco, CA 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich C.","family":"Strauss","sequence":"additional","affiliation":[{"name":"\u2020Proctor Foundation, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"*Diabetes Center,"},{"name":"\u2021Department of Medicine, University of California-San Francisco, San Francisco, CA 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,4,15]]},"reference":[{"key":"2023010203124931300_r1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0049-0172(84)90001-5","article-title":"Primary Sjogren syndrome: clinical and immunopathologic features.","volume":"14","author":"Fox","year":"1984","journal-title":"Semin. 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