{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T01:22:53Z","timestamp":1769649773606,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Agonistic anti-CD137 mAbs either positively or negatively regulate T cell function. When administered at the beginning of lymphocytic choriomeningitis virus Armstrong infection anti-CD137 induced immunosuppression and T cell deletion, and in the case of influenza infection led to increased mortality. In contrast, 72 h delay in anti-CD137 treatment led to an enhanced virus-specific CD8 T cell response and rapid viral clearance. Virus-specific CD8 T cells in anti-CD137\u2013injected mice rapidly upregulate Fas expression, and although necessary, was insufficient to induce CD8 T cell deletion. Strikingly, CD137 signaling in T cells was found to be insufficient to induce suppression or deletion. Rather, immunosuppression and T cell deletion was only observed if CD137 signals were provided to T cells and dendritic cells (DCs). In vitro CD137 crosslinking in DCs led to phosphorylation of Stat3, and importantly, anti-CD137 treatment of lymphocytic choriomeningitis virus Armstrong infected Stat3 conditional knock-out mice induced neither immune suppression or T cell deletion. Taken together, these data suggest that CD137 signaling in DCs can regulate CD8 T cell survival through a Stat3 and Fas-mediated pathway.<\/jats:p>","DOI":"10.4049\/jimmunol.0902713","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T23:34:10Z","timestamp":1269905650000},"page":"4770-4778","source":"Crossref","is-referenced-by-count":25,"title":["Dendritic Cells and Stat3 Are Essential for CD137-Induced CD8 T Cell Activation-Induced Cell Death"],"prefix":"10.1093","volume":"184","author":[{"given":"Benyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Emory Vaccine Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liguo","family":"Niu","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony T","family":"Vella","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emory University School of Medicine , Atlanta, GA 30329"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S","family":"Mittler","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center"},{"name":"Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"2026012808083032100_r1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.immunol.23.021704.115839","article-title":"TNF\/TNFR family members in costimulation of T cell responses.","volume":"23","author":"Watts","year":"2005","journal-title":"Annu. 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