{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:43:52Z","timestamp":1790253832282,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T00:00:00Z","timestamp":1263772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of \u03b3\u03b4 and double negative (DN) \u03b1\u03b2 T cells. These cells were rapidly recruited to the site of infection and produced large amounts of IL-17, IFN-\u03b3, and TNF-\u03b1. Notably, DN T cells transferred into L. monocytogenes-infected RAG2\u2212\/\u2212 mice prevented bacterial growth, confirming their protective role against intracellular pathogens. Our results show that IL-23 regulates the function of IL-17\u2013producing \u03b3\u03b4 and DN T cells, two essential components of the early protective immune response directed against intracellular pathogens.<\/jats:p>","DOI":"10.4049\/jimmunol.0902796","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T21:40:27Z","timestamp":1263850827000},"page":"1710-1720","source":"Crossref","is-referenced-by-count":103,"title":["IL-23 Receptor Regulates Unconventional IL-17\u2013Producing T Cells That Control Bacterial Infections"],"prefix":"10.1093","volume":"184","author":[{"given":"Lorena","family":"Riol-Blanco","sequence":"first","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanja","family":"Lazarevic","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health , Boston MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Mitsdoerffer","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S","family":"Wilson","sequence":"additional","affiliation":[{"name":"Diabetes Research Laboratories, Massachusetts General Hospital , Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Croxford","sequence":"additional","affiliation":[{"name":"1st Medical Department, Johannes Gutenberg University of Mainz , Mainz,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[{"name":"1st Medical Department, Johannes Gutenberg University of Mainz , Mainz,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H","family":"Glimcher","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health , Boston MA 02115"},{"name":"Department of Medicine, Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Oukka","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute"},{"name":"Department of Immunology, School of Medicine, University of Washington , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,1,18]]},"reference":[{"key":"2026012806315336800_r1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.0105-2896.2004.00214.x","article-title":"IL-12 and IL-23: master regulators of innate and adaptive immunity.","volume":"202","author":"Langrish","year":"2004","journal-title":"Immunol. 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