{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:35:29Z","timestamp":1790516129529,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T00:00:00Z","timestamp":1260748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nonselective inhibition of PG synthesis augments inflammation in mouse models of airway disease, but the roles of individual PGs are not completely clarified. To investigate the role of PGE2 in a mouse model of airway inflammation induced by a natural allergen, we used mice lacking the critical terminal synthetic enzyme, microsomal PGE2 synthase (mPGES)-1. Mice lacking mPGES-1 (ptges\u2212\/\u2212 mice) and wild-type C57BL\/6 controls were challenged intranasally with low doses of an extract derived from the house dust mite Dermatophagoides farinae (Der f). The levels of PGE2 in the bronchoalveolar lavage fluids of Der f-treated ptges\u2212\/\u2212 mice were \u223c80% lower than the levels in wild-type controls. Der f-induced bronchovascular eosinophilia was modestly enhanced in the ptges\u2212\/\u2212 mice. Both Der f-treated strains showed similar increases in serum IgE and IgG1, as well as comparable levels of Th1, Th2, and Th17 cytokine production by Der f-stimulated spleen cells. These findings indicated that mPGES-1\u2013derived PGE2 was not required for allergen sensitization or development of effector T cell responses. Unexpectedly, the numbers of vascular smooth muscle cells and the thickness of intrapulmonary vessels were both markedly increased in the Der f-treated ptges\u2212\/\u2212 mice. These vascular changes were suppressed by the administration of the stable PGE2 analog 16, 16-dimethyl PGE2, or of selective agonists of the E-prostanoid (EP) 1, EP2, and EP3 receptors, respectively, for PGE2. Thus, mPGES-1 and its product, PGE2, protect the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation, and these effects may be mediated by more than one EP receptor.<\/jats:p>","DOI":"10.4049\/jimmunol.0902835","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T19:21:07Z","timestamp":1261164067000},"page":"433-441","source":"Crossref","is-referenced-by-count":68,"title":["Prostaglandin E2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation"],"prefix":"10.1093","volume":"184","author":[{"given":"Anders","family":"Lundequist","sequence":"first","affiliation":[{"name":"Department of Medicine"},{"name":"Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samridhi N","family":"Nallamshetty","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M","family":"Laidlaw","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A","family":"Boyce","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,14]]},"reference":[{"key":"2025032710022009800_r1","first-page":"65","article-title":"A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems.","volume":"59","author":"Fortier","year":"2008","journal-title":"J. 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Cellular, mediator, and permeability changes.","volume":"144","author":"Liu","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"2025032710022009800_r37","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.4049\/jimmunol.182.2.1119","article-title":"Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.","volume":"182","author":"Barrett","year":"2009","journal-title":"J. Immunol."},{"key":"2025032710022009800_r38","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1164\/rccm.200308-1094OC","article-title":"Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling.","volume":"169","author":"Johnson","year":"2004","journal-title":"Am. J. Respir. Crit. 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