{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:53:57Z","timestamp":1791021237258,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Administration of attenuated pathogenic T cell clones, a procedure known as T cell vaccination, induces CD8+ T cells specific for peptides derived from the V\u03b2-chain of the TCR presented by the MHC class Ib molecule, Qa-1 expressed on the vaccine cells. These regulatory CD8+ T cells have the capacity to control the activation of endogenous T cells expressing the same TCR V\u03b2-chain as the vaccinating cells. We hypothesized that vaccination with NKT cells could also induce Qa-1\u2013restricted CD8+ T cells that would control NKT cell activation. We tested this hypothesis in a murine model of Con A-induced hepatitis that is induced by NKT cells. Vaccination with NKT cells effectively induced protective Qa-1\u2013restricted CD8+ T cells that prevented hepatitis. Surprisingly, upon vaccination with T cells expressing V\u03b2-chains irrelevant to NKT cells, we discovered that the specificity of vaccine-induced Qa-1\u2013restricted CD8+ T cells was not limited to the V\u03b2-chain of the vaccinating cells. We further show that these regulatory Qa-1\u2013restricted CD8+ T cells arise spontaneously upon polyclonal activation of T cells in the absence of deliberate T cell vaccination. These experiments provide new insight into a CD8+ T cell compartment that regulates the immediate reactivation of conventional T cells and NKT cells.<\/jats:p>","DOI":"10.4049\/jimmunol.0903109","type":"journal-article","created":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T23:07:04Z","timestamp":1274310424000},"page":"6585-6591","source":"Crossref","is-referenced-by-count":28,"title":["Control of T Cell Reactivation by Regulatory Qa-1\u2013Restricted CD8+ T Cells"],"prefix":"10.1093","volume":"184","author":[{"given":"Aditi","family":"Varthaman","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U698"},{"name":"Universit\u00e9 Denis Diderot Paris 7, H\u00f4pital Bichat-Claude Bernard"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U872, Centre de Recherche des Cordeliers, Equipe 16, Universit\u00e9 de Pierre et Marie Curie Paris 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila","family":"Khallou-Laschet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U698"},{"name":"Universit\u00e9 Denis Diderot Paris 7, H\u00f4pital Bichat-Claude Bernard"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U872, Centre de Recherche des Cordeliers, Equipe 16, Universit\u00e9 de Pierre et Marie Curie Paris 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Clement","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U698"},{"name":"Universit\u00e9 Denis Diderot Paris 7, H\u00f4pital Bichat-Claude Bernard"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U872, Centre de Recherche des Cordeliers, Equipe 16, Universit\u00e9 de Pierre et Marie Curie Paris 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National de la Sant\u00e9 et de la Recherche M\u00e9dicale U872, Centre de Recherche des Cordeliers, Equipe 16, Universit\u00e9 de Pierre et Marie Curie Paris 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Herbelin","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 8147, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Descartes, H\u00f4pital Necker , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Kaveri","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U872, Centre de Recherche des Cordeliers, Equipe 16, Universit\u00e9 de Pierre et Marie Curie Paris 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Cantor","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, 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