{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T01:26:19Z","timestamp":1769649979116,"version":"3.49.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2009,12,27]],"date-time":"2009-12-27T00:00:00Z","timestamp":1261872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autoimmune lymphocytic infiltration of the salivary glands, termed sialadenitis, is a pathologic feature of Sj\u00f6gren\u2019s syndrome (SjS) that is also prominent in nonobese diabetic (NOD) mice. Genetic factors regulate sialadenitis, and a previous (NOD \u00d7 NZW)F2 study detected linkage to murine chromosome (Chr) 7. The locus, subsequently annotated as Ssial3, maps to the distal end of Chr7 and overlaps a region associated with type 1 diabetes susceptibility in NOD mice. To examine whether Ssial3 could contribute to both diseases, or was specific for SjS, we generated a congenic mouse strain that harbored an NZW-derived Chr7 interval on the NOD genetic background. This congenic strain exhibited reduced sialadenitis compared with NOD mice and confirmed Ssial3. This reduction, however, did not ameliorate saliva abnormalities associated with SjS-like disease in NOD mice, nor were congenic mice protected against insulitis (lymphocytic infiltration of the pancreatic islets) or diabetes onset. Thus, the Ssial3 locus appears to have a tissue-specific effect for which the NZW allele is unable to prevent other autoimmune traits in the NOD mouse. Anomalous increases for antinuclear Ab production and frequency of marginal-zone B cells were also identified in congenic mice, indicating that the NZW-derived Chr7 interval has a complex effect on the NOD immune system.<\/jats:p>","DOI":"10.4049\/jimmunol.0903149","type":"journal-article","created":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T22:26:22Z","timestamp":1260397582000},"page":"859-868","source":"Crossref","is-referenced-by-count":7,"title":["An NZW-Derived Interval on Chromosome 7 Moderates Sialadenitis, But Not Insulitis in Congenic Nonobese Diabetic Mice"],"prefix":"10.1093","volume":"184","author":[{"given":"Rachel A","family":"Burt","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Watkins","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research"},{"name":"Department of Medical Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris K L","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology"},{"name":"St Vincent\u2019s Institute of Medical Research , Fitzroy, Victoria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Biology"},{"name":"St Vincent\u2019s Institute of Medical Research , Fitzroy, Victoria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Quirk","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Mackin","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Institute of Medical Research , Fitzroy, Victoria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Morgan","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Guo","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart P","family":"Berzins","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne , Parkville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Morahan","sequence":"additional","affiliation":[{"name":"Centre for Diabetes Research, The Western Australian Institute for Medical Research"},{"name":"Centre for Medical Research, University of Western Australia , Perth, Western Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C","family":"Brodnicki","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Institute of Medical Research , Fitzroy, Victoria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,27]]},"reference":[{"key":"2026012808101990700_r1","first-page":"1","article-title":"Breeding of a non-obese, diabetic strain of mice.","volume":"29","author":"Makino","year":"1980","journal-title":"Jikken Dobutsu"},{"key":"2026012808101990700_r2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000060527","article-title":"Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice.","volume":"4","author":"Serreze","year":"2001","journal-title":"Curr. Dir. Autoimmun."},{"key":"2026012808101990700_r3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/clin.1996.0050","article-title":"Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice.","volume":"79","author":"Robinson","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"2026012808101990700_r4","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1073\/pnas.94.11.5767","article-title":"Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sj\u00f6gren syndrome.","volume":"94","author":"Robinson","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026012808101990700_r5","first-page":"675","article-title":"Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice.","volume":"16","author":"Kong","year":"1998","journal-title":"Clin. Exp. Rheumatol."},{"key":"2026012808101990700_r6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000049194","article-title":"Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy.","volume":"18","author":"Cha","year":"2001","journal-title":"Exp. Clin. Immunogenet."},{"key":"2026012808101990700_r7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12016-007-8012-7","article-title":"Animal models of Sj\u00f6gren\u2019s syndrome.","volume":"32","author":"Jonsson","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"2026012808101990700_r8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1365-3083.2003.01235.x","article-title":"Genetic heterogeneity of autoimmune disorders in the nonobese diabetic mouse.","volume":"57","author":"Johansson","year":"2003","journal-title":"Scand. J. Immunol."},{"key":"2026012808101990700_r9","first-page":"91","article-title":"Animal models of type 1 diabetes: genetics and immunological function.","volume":"552","author":"Lang","year":"2004","journal-title":"Adv. Exp. Med. Biol."},{"key":"2026012808101990700_r10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11892-005-0042-z","article-title":"Nonobese diabetic mice and the genetics of diabetes susceptibility.","volume":"5","author":"Leiter","year":"2005","journal-title":"Curr. Diab. Rep."},{"key":"2026012808101990700_r11","doi-asserted-by":"crossref","first-page":"11533","DOI":"10.1073\/pnas.191383798","article-title":"Transgenic rescue implicates \u03b22-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice.","volume":"98","author":"Hamilton-Williams","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026012808101990700_r12","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature01621","article-title":"Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.","volume":"423","author":"Ueda","year":"2003","journal-title":"Nature"},{"key":"2026012808101990700_r13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ng1766","article-title":"In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.","volume":"38","author":"Kissler","year":"2006","journal-title":"Nat. Genet."},{"key":"2026012808101990700_r14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ng1958","article-title":"Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.","volume":"39","author":"Yamanouchi","year":"2007","journal-title":"Nat. Genet."},{"key":"2026012808101990700_r15","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cell.2006.10.038","article-title":"TRPV1+ sensory neurons control \u03b2 cell stress and islet inflammation in autoimmune diabetes.","volume":"127","author":"Razavi","year":"2006","journal-title":"Cell"},{"key":"2026012808101990700_r16","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/hmg\/ddl209","article-title":"Identification of the transcription factor Arntl2 as a candidate gene for the type 1 diabetes locus Idd6","volume":"15","author":"Hung","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"2026012808101990700_r17","doi-asserted-by":"crossref","first-page":"734","DOI":"10.2337\/diabetes.55.03.06.db05-1059","article-title":"Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice.","volume":"55","author":"Laloraya","year":"2006","journal-title":"Diabetes"},{"key":"2026012808101990700_r18","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.4049\/jimmunol.168.8.4192","article-title":"Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1.","volume":"168","author":"Boulard","year":"2002","journal-title":"J. Immunol."},{"key":"2026012808101990700_r19","first-page":"1896","article-title":"Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sj\u00f6gren\u2019s syndrome-like autoimmune exocrinopathy.","volume":"27","author":"Brayer","year":"2000","journal-title":"J. Rheumatol."},{"key":"2026012808101990700_r20","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/art.10258","article-title":"Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sj\u00f6gren\u2019s syndrome) on a healthy murine background.","volume":"46","author":"Cha","year":"2002","journal-title":"Arthritis Rheum."},{"key":"2026012808101990700_r21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/1521-4141(200201)32:1<243::AID-IMMU243>3.0.CO;2-X","article-title":"The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross.","volume":"32","author":"Johansson","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"2026012808101990700_r22","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.2337\/diabetes.54.12.3453","article-title":"Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice.","volume":"54","author":"Brodnicki","year":"2005","journal-title":"Diabetes"},{"key":"2026012808101990700_r23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1074-7613(00)00012-1","article-title":"The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.","volume":"13","author":"Lyons","year":"2000","journal-title":"Immunity"},{"key":"2026012808101990700_r24","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/ar2300","article-title":"The influence of the NOD Nss1\/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice.","volume":"9","author":"Hjelmervik","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"2026012808101990700_r25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng0893-404","article-title":"Polygenic control of autoimmune diabetes in nonobese diabetic mice.","volume":"4","author":"Ghosh","year":"1993","journal-title":"Nat. Genet."},{"key":"2026012808101990700_r26","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2337\/diab.44.10.1186","article-title":"Crosses of NOD mice with the related NON strain. A polygenic model for IDDM.","volume":"44","author":"McAleer","year":"1995","journal-title":"Diabetes"},{"key":"2026012808101990700_r27","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1074-7613(00)80405-7","article-title":"Genetic control of diabetes progression.","volume":"7","author":"Gonzalez","year":"1997","journal-title":"Immunity"},{"key":"2026012808101990700_r28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/clim.2000.4893","article-title":"Derivation of diabetes-resistant congenic lines from the nonobese diabetic mouse.","volume":"96","author":"McDuffie","year":"2000","journal-title":"Clin. Immunol."},{"key":"2026012808101990700_r29","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00335-005-0007-1","article-title":"\u201cAgouti NOD\u201d: identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.","volume":"16","author":"Chen","year":"2005","journal-title":"Mamm. Genome"},{"key":"2026012808101990700_r30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0090-1229(80)90198-1","article-title":"Age- and sex-related glomerulonephritis in New Zealand white mice.","volume":"16","author":"Kelley","year":"1980","journal-title":"Clin. Immunol. Immunopathol."},{"key":"2026012808101990700_r31","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1084\/jem.165.5.1237","article-title":"The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.","volume":"165","author":"Kotzin","year":"1987","journal-title":"J. Exp. Med."},{"key":"2026012808101990700_r32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/genetics\/131.2.423","article-title":"A genetic map of the mouse suitable for typing intraspecific crosses.","volume":"131","author":"Dietrich","year":"1992","journal-title":"Genetics"},{"key":"2026012808101990700_r33","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.2337\/diab.37.8.1108","article-title":"Progression from insulitis to \u03b2-cell destruction in NOD mouse requires L3T4+ T-lymphocytes.","volume":"37","author":"Charlton","year":"1988","journal-title":"Diabetes"},{"key":"2026012808101990700_r34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.0300-9475.2004.01508.x","article-title":"A dual role for interferon-\u03b3 in the pathogenesis of Sjogren\u2019s syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse.","volume":"60","author":"Cha","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"2026012808101990700_r35","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/rheumatology\/keg170","article-title":"The association of antinuclear antibodies with organ involvement and survival in systemic sclerosis.","volume":"42","author":"Hesselstrand","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"2026012808101990700_r36","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/exer.1999.0715","article-title":"Impact of gender on exocrine gland inflammation in mouse models of Sj\u00f6gren\u2019s syndrome.","volume":"69","author":"Toda","year":"1999","journal-title":"Exp. Eye Res."},{"key":"2026012808101990700_r37","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2337\/diabetes.51.7.2141","article-title":"An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice.","volume":"51","author":"Boulard","year":"2002","journal-title":"Diabetes"},{"key":"2026012808101990700_r38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren\u2019s syndrome.","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"2026012808101990700_r39","first-page":"E607","article-title":"Functional changes in salivary glands of autoimmune disease-prone NOD mice.","volume":"263","author":"Hu","year":"1992","journal-title":"Am. J. Physiol."},{"key":"2026012808101990700_r40","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/978-1-4615-2417-5_105","article-title":"Utilization of the non-obese diabetic (NOD) mouse as an animal model for the study of secondary Sj\u00f6gren\u2019s syndrome.","volume":"350","author":"Humphreys-Beher","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"2026012808101990700_r41","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1002\/art.21945","article-title":"Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland.","volume":"54","author":"Jonsson","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2026012808101990700_r42","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2249.2005.02930.x","article-title":"Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis.","volume":"142","author":"Rosignoli","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"2026012808101990700_r43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jaut.2005.11.004","article-title":"Sj\u00f6gren\u2019s syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease.","volume":"26","author":"Gao","year":"2006","journal-title":"J. Autoimmun."},{"key":"2026012808101990700_r44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/1529-0131(199801)41:1<150::AID-ART18>3.0.CO;2-T","article-title":"A novel NOD-derived murine model of primary Sj\u00f6gren\u2019s syndrome.","volume":"41","author":"Robinson","year":"1998","journal-title":"Arthritis Rheum."},{"key":"2026012808101990700_r45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-3083.2006.01828.x","article-title":"Sj\u00f6gren\u2019s syndrome-like disease of C57BL\/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus.","volume":"64","author":"Nguyen","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"2026012808101990700_r46","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.4049\/jimmunol.179.4.2318","article-title":"Development of Sjogren\u2019s syndrome in nonobese diabetic-derived autoimmune-prone C57BL\/6.NOD-Aec1Aec2 mice is dependent on complement component-3.","volume":"179","author":"Nguyen","year":"2007","journal-title":"J. Immunol."},{"key":"2026012808101990700_r47","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2337\/diabetes.52.1.218","article-title":"A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.","volume":"52","author":"Brodnicki","year":"2003","journal-title":"Diabetes"},{"key":"2026012808101990700_r48","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1006\/clin.1993.1137","article-title":"Characterization of antinuclear autoantibodies present in the serum from nonobese diabetic (NOD) mice.","volume":"68","author":"Humphreys-Beher","year":"1993","journal-title":"Clin. Immunol. Immunopathol."},{"key":"2026012808101990700_r49","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1365-3083.1994.tb03419.x","article-title":"Mycobacteria precipitate autoimmune rheumatic disease in NOD mice via an adjuvant-like activity.","volume":"39","author":"Baxter","year":"1994","journal-title":"Scand. J. Immunol."},{"key":"2026012808101990700_r50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/art.1780120403","article-title":"Autoantibodies and nephritis in the white strain (NZW) of New Zealand mice.","volume":"12","author":"Hahn","year":"1969","journal-title":"Arthritis Rheum."},{"key":"2026012808101990700_r51","first-page":"829","article-title":"Genesis of antinuclear antibody in NZB-W mice: role of genetic factors and of viral infections.","volume":"6","author":"Lambert","year":"1970","journal-title":"Clin. Exp. Immunol."},{"key":"2026012808101990700_r52","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.2741\/2187","article-title":"Sj\u00f6gren\u2019s syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies.","volume":"12","author":"Nguyen","year":"2007","journal-title":"Front. Biosci."},{"key":"2026012808101990700_r53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI0214121","article-title":"Association of BAFF\/BLyS overexpression and altered B cell differentiation with Sj\u00f6gren\u2019s syndrome.","volume":"109","author":"Groom","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2026012808101990700_r54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00251-005-0066-1","article-title":"Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region.","volume":"58","author":"Irie","year":"2006","journal-title":"Immunogenetics"},{"key":"2026012808101990700_r55","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/1074-7613(94)90100-7","article-title":"Polygenic control of susceptibility to murine systemic lupus erythematosus.","volume":"1","author":"Morel","year":"1994","journal-title":"Immunity"},{"key":"2026012808101990700_r56","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/sj.gene.6364426","article-title":"Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis.","volume":"8","author":"Liu","year":"2007","journal-title":"Genes Immun."},{"key":"2026012808101990700_r57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/197197a0","article-title":"Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice.","volume":"197","author":"Helyer","year":"1963","journal-title":"Nature"},{"key":"2026012808101990700_r58","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1073\/pnas.95.13.7538","article-title":"Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sj\u00f6gren\u2019s syndrome.","volume":"95","author":"Robinson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026012808101990700_r59","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nri799","article-title":"Marginal-zone B cells.","volume":"2","author":"Martin","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2026012808101990700_r60","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.4049\/jimmunol.172.8.5086","article-title":"B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice.","volume":"172","author":"Silveira","year":"2004","journal-title":"J. Immunol."},{"key":"2026012808101990700_r61","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2337\/db07-0589","article-title":"Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells.","volume":"57","author":"Mari\u00f1o","year":"2008","journal-title":"Diabetes"},{"key":"2026012808101990700_r62","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.4049\/jimmunol.180.5.3250","article-title":"Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.","volume":"180","author":"Serreze","year":"2008","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/2\/859\/62711787\/ji_0903149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/2\/859\/62711787\/ji_0903149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:12:06Z","timestamp":1769605926000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/2\/859\/8013577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,27]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,12,27]]},"published-print":{"date-parts":[[2010,1,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0903149","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,1]]},"published":{"date-parts":[[2009,12,27]]}}}