{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:37:43Z","timestamp":1791376663475,"version":"4.3.2"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL096348"],"award-info":[{"award-number":["HL096348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL083044"],"award-info":[{"award-number":["HL083044"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL081764"],"award-info":[{"award-number":["HL081764"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fever is common in critically ill patients and is associated with worse clinical outcomes, including increased intensive care unit mortality. In animal models, febrile-range hyperthermia (FRH) worsens acute lung injury, but the mechanisms by which this occurs remain uncertain. We hypothesized that FRH augments the response of the alveolar epithelium to TNF-\u03b1 receptor family signaling. We found that FRH augmented LPS-induced lung injury and increased LPS-induced mortality in mice. At 24 h, animals exposed to hyperthermia and LPS had significant increases in alveolar permeability without changes in inflammatory cells in bronchoalveolar lavage fluid or lung tissue as compared with animals exposed to LPS alone. The increase in alveolar permeability was associated with an increase in alveolar epithelial apoptosis and was attenuated by caspase inhibition with zVAD.fmk. At 48 h, the animals exposed to hyperthermia and LPS had an enhanced lung inflammatory response. In murine lung epithelial cell lines (MLE-15, LA-4) and in primary type II alveolar epithelial cells, FRH enhanced apoptosis in response to TNF-\u03b1 but not Fas ligand. The increase in apoptosis was caspase-8 dependent and associated with suppression of NF-\u03baB activity. The FRH-associated NF-\u03baB suppression was not associated with persistence of I\u03baB-\u03b1, suggesting that FRH-mediated suppression of NF-\u03baB occurs by means other than alteration of I\u03baB-\u03b1 kinetics. These data show for the first time that FRH promotes lung injury in part by increasing lung epithelial apoptosis. The enhanced apoptotic response might relate to FRH-mediated suppression of NF-\u03baB activity in the alveolar epithelium with a resultant increase in susceptibility to TNF-\u03b1\u2013mediated cell death.<\/jats:p>","DOI":"10.4049\/jimmunol.0903191","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T22:44:45Z","timestamp":1267656285000},"page":"3801-3813","source":"Crossref","is-referenced-by-count":35,"title":["Febrile-Range Hyperthermia Augments Lipopolysaccharide-Induced Lung Injury by a Mechanism of Enhanced Alveolar Epithelial Apoptosis"],"prefix":"10.1093","volume":"184","author":[{"given":"Anne B","family":"Lipke","sequence":"first","affiliation":[{"name":"Medical Research Service, VA Puget Sound Medical Center, University of Washington , Seattle, WA 98108"},{"name":"Division of Pulmonary and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Matute-Bello","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine"},{"name":"Center for Lung Biology, Department of Medicine, University of Washington , Seattle, WA 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Herrero","sequence":"additional","affiliation":[{"name":"Medical Research Service, VA Puget Sound Medical Center, University of Washington , Seattle, WA 98108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoyasu","family":"Kurahashi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine , Yokohama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venus A","family":"Wong","sequence":"additional","affiliation":[{"name":"Medical Research Service, VA Puget Sound Medical Center, University of Washington , Seattle, WA 98108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Mongovin","sequence":"additional","affiliation":[{"name":"Medical Research Service, VA Puget Sound Medical Center, University of Washington , Seattle, WA 98108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Martin","sequence":"additional","affiliation":[{"name":"Medical Research Service, VA Puget Sound Medical Center, University of Washington , Seattle, WA 98108"},{"name":"Center for Lung Biology, Department of Medicine, University of Washington , Seattle, WA 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"2026012806282213600_r1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1097\/CCM.0b013e318170efd3","article-title":"Occurrence and outcome of fever in critically ill adults.","volume":"36","author":"Laupland","year":"2008","journal-title":"Crit. Care Med."},{"key":"2026012806282213600_r2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00134-004-2166-z","article-title":"Body temperature alterations in the critically ill.","volume":"30","author":"Peres Bota","year":"2004","journal-title":"Intensive Care Med."},{"key":"2026012806282213600_r3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s001340050928","article-title":"A prospective study of fever in the intensive care unit.","volume":"25","author":"Circiumaru","year":"1999","journal-title":"Intensive Care Med."},{"key":"2026012806282213600_r4","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jamcollsurg.2007.01.033","article-title":"Is fever protective in surgical patients with bloodstream infection?","volume":"204","author":"Swenson","year":"2007","journal-title":"J. Am. Coll. Surg"},{"key":"2026012806282213600_r5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1113\/jphysiol.1978.sp012460","article-title":"Fever and survival in rabbits infected with Pasteurella multocida.","volume":"282","author":"Kluger","year":"1978","journal-title":"J. Physiol."},{"key":"2026012806282213600_r6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/252473a0","article-title":"Fever in the lizard Dipsosaurus dorsalis.","volume":"252","author":"Vaughn","year":"1974","journal-title":"Nature"},{"key":"2026012806282213600_r7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/0002-9343(78)90578-8","article-title":"Spontaneous bacterial peritonitis. A review of 28 cases with emphasis on improved survival and factors influencing prognosis.","volume":"64","author":"Weinstein","year":"1978","journal-title":"Am. J. Med."},{"key":"2026012806282213600_r8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1001\/archinte.1971.00310130124022","article-title":"Factors affecting mortality of gram-negative rod bacteremia.","volume":"127","author":"Bryant","year":"1971","journal-title":"Arch. Intern. Med."},{"key":"2026012806282213600_r9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/sur.2004.5.145","article-title":"Causes and consequences of fever complicating critical surgical illness.","volume":"5","author":"Barie","year":"2004","journal-title":"Surg. Infect. (Larchmt)"},{"key":"2026012806282213600_r10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11255-007-9323-6","article-title":"Glomerulonephritis causing acute renal failure during the course of bacterial infections. Histological varieties, potential pathogenetic pathways and treatment.","volume":"40","author":"Zeledon","year":"2008","journal-title":"Int. Urol. Nephrol."},{"key":"2026012806282213600_r11","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.4049\/jimmunol.174.6.3676","article-title":"Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia.","volume":"174","author":"Rice","year":"2005","journal-title":"J. Immunol."},{"key":"2026012806282213600_r12","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/S0002-9440(10)64333-7","article-title":"Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicity.","volume":"162","author":"Hasday","year":"2003","journal-title":"Am. J. Pathol."},{"key":"2026012806282213600_r13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/01.CCM.0000098857.14923.44","article-title":"Effect of core body temperature on ventilator-induced lung injury.","volume":"32","author":"Suzuki","year":"2004","journal-title":"Crit. Care Med."},{"key":"2026012806282213600_r14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jcrc.2004.11.001","article-title":"Effects of body temperature on ventilator-induced lung injury.","volume":"20","author":"Akinci","year":"2005","journal-title":"J. Crit. Care"},{"key":"2026012806282213600_r15","first-page":"F87","article-title":"Body temperature: an important determinant of severity of ischemic renal injury.","volume":"251","author":"Zager","year":"1986","journal-title":"Am. J. Physiol."},{"key":"2026012806282213600_r16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1513\/pats.200504-031AC","article-title":"Apoptosis and epithelial injury in the lungs.","volume":"2","author":"Martin","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"2026012806282213600_r17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H","article-title":"TNF alpha and the TNF receptor superfamily: structure-function relationship(s).","volume":"50","author":"Idriss","year":"2000","journal-title":"Microsc. Res. Tech."},{"key":"2026012806282213600_r18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2119\/2008-00011.Perl","article-title":"Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-a unifying hypothesis? What we have learned from small interfering RNAs.","volume":"14","author":"Perl","year":"2008","journal-title":"Mol. Med."},{"key":"2026012806282213600_r19","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1128\/IAI.69.9.5768-5776.2001","article-title":"Fas\/Fas ligand system mediates epithelial injury, but not pulmonary host defenses, in response to inhaled bacteria.","volume":"69","author":"Matute-Bello","year":"2001","journal-title":"Infect. Immun."},{"key":"2026012806282213600_r20","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.4049\/jimmunol.175.6.4069","article-title":"Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung.","volume":"175","author":"Matute-Bello","year":"2005","journal-title":"J. Immunol."},{"key":"2026012806282213600_r21","doi-asserted-by":"crossref","first-page":"L328","DOI":"10.1152\/ajplung.2001.281.2.L328","article-title":"Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits.","volume":"281","author":"Matute-Bello","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2026012806282213600_r22","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.4049\/jimmunol.163.4.2217","article-title":"Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS).","volume":"163","author":"Matute-Bello","year":"1999","journal-title":"J. Immunol."},{"key":"2026012806282213600_r23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0002-9440(10)63953-3","article-title":"Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation.","volume":"158","author":"Matute-Bello","year":"2001","journal-title":"Am. J. Pathol."},{"key":"2026012806282213600_r24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2567.2003.01724.x","article-title":"Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue.","volume":"110","author":"Wortinger","year":"2003","journal-title":"Immunology"},{"key":"2026012806282213600_r25","first-page":"358","article-title":"Sustained lipopolysaccharide-induced lung inflammation in mice is attenuated by functional deficiency of the Fas\/Fas ligand system.","volume":"11","author":"Matute-Bello","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"2026012806282213600_r26","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1086\/427261","article-title":"Blockade of the Fas\/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen.","volume":"191","author":"Matute-Bello","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2026012806282213600_r27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9440(10)62290-0","article-title":"Relationship of acute lung inflammatory injury to Fas\/FasL system.","volume":"166","author":"Neff","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2026012806282213600_r28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1164\/rccm.200611-1743OC","article-title":"Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury.","volume":"176","author":"Perl","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026012806282213600_r29","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0002-9440(10)61240-0","article-title":"Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis.","volume":"167","author":"Perl","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2026012806282213600_r30","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s10495-007-0125-1","article-title":"Lung injury after ischemia-reperfusion of small intestine in rats involves apoptosis of type II alveolar epithelial cells mediated by TNF-alpha and activation of Bid pathway.","volume":"12","author":"An","year":"2007","journal-title":"Apoptosis"},{"key":"2026012806282213600_r31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.rmed.2007.10.001","article-title":"Evaluation of bronchoalveolar lavage fluid from ARDS patients with regard to apoptosis.","volume":"102","author":"Lee","year":"2008","journal-title":"Respir. Med."},{"key":"2026012806282213600_r32","article-title":"Potential role of soluble TRAIL in epithelial injury in children with severe RSV infection.","author":"Bem","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"2026012806282213600_r33","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.cdd.4401278","article-title":"Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis.","volume":"10","author":"Tran","year":"2003","journal-title":"Cell Death Differ."},{"key":"2026012806282213600_r34","first-page":"650","article-title":"Synergistic cytotoxic and antitumor effects of recombinant human tumor necrosis factor and hyperthermia.","volume":"48","author":"Watanabe","year":"1988","journal-title":"Cancer Res."},{"key":"2026012806282213600_r35","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1349-7006.1992.tb01962.x","article-title":"Mechanism of synergistic cytotoxic effect between tumor necrosis factor and hyperthermia.","volume":"83","author":"Yamauchi","year":"1992","journal-title":"Jpn. J. Cancer Res."},{"key":"2026012806282213600_r36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/02656730601074052","article-title":"Hyperthermia enhances tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human cancer cells.","volume":"22","author":"Yoo","year":"2006","journal-title":"Int. J. Hyperthermia"},{"key":"2026012806282213600_r37","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s10495-007-0096-2","article-title":"Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis.","volume":"12","author":"Moulin","year":"2007","journal-title":"Apoptosis"},{"key":"2026012806282213600_r38","doi-asserted-by":"crossref","first-page":"L314","DOI":"10.1152\/ajplung.00210.2007","article-title":"Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice.","volume":"295","author":"Bem","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2026012806282213600_r39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1165\/ajrcmb.14.4.8600933","article-title":"Isolation and primary culture of murine alveolar type II cells.","volume":"14","author":"Corti","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026012806282213600_r40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2026012806282213600_r41","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/rccm.200804-534OC","article-title":"Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis.","volume":"179","author":"Matsuda","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026012806282213600_r42","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/3276","article-title":"Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand.","volume":"4","author":"Miwa","year":"1998","journal-title":"Nat. Med."},{"key":"2026012806282213600_r43","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1538-7836.2007.02479.x","article-title":"In vivo effects of hyperthermia on the functional and conformational characteristics of antithrombin.","volume":"5","author":"Hern\u00e1ndez-Espinosa","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"2026012806282213600_r44","doi-asserted-by":"crossref","first-page":"24313","DOI":"10.1074\/jbc.271.40.24313","article-title":"Sounding the alarm: protein kinase cascades activated by stress and inflammation.","volume":"271","author":"Kyriakis","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2026012806282213600_r45","first-page":"262","article-title":"Hyperthermic modulation of tumor necrosis factor-dependent monocyte\/macrophage tumor cytotoxicity in vitro.","volume":"8","author":"Klostergaard","year":"1989","journal-title":"J. Biol. Response Mod."},{"key":"2026012806282213600_r46","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jcb.20729","article-title":"Hyperthermia engages the intrinsic apoptotic pathway by enhancing upstream caspase activation to overcome apoptotic resistance in MCF-7 breast adenocarcinoma cells.","volume":"98","author":"Klostergaard","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"2026012806282213600_r47","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4049\/jimmunol.174.1.223","article-title":"Hyperthermia enhances CD95-ligand gene expression in T lymphocytes.","volume":"174","author":"Cippitelli","year":"2005","journal-title":"J. Immunol."},{"key":"2026012806282213600_r48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3835(03)00463-4","article-title":"Hyperthermia enhances tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line.","volume":"201","author":"Kokura","year":"2003","journal-title":"Cancer Lett."},{"key":"2026012806282213600_r49","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/35104568","article-title":"Inhibition of JNK activation through NF-kappaB target genes.","volume":"414","author":"Tang","year":"2001","journal-title":"Nature"},{"key":"2026012806282213600_r50","doi-asserted-by":"crossref","first-page":"8961","DOI":"10.1038\/sj.onc.1207230","article-title":"To be, or not to be: NF-kappaB is the answer\u2014role of Rel\/NF-kappaB in the regulation of apoptosis.","volume":"22","author":"Kucharczak","year":"2003","journal-title":"Oncogene"},{"key":"2026012806282213600_r51","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4161\/cc.3.12.1321","article-title":"NF-kappaB and JNK: an intricate affair.","volume":"3","author":"Bubici","year":"2004","journal-title":"Cell Cycle"},{"key":"2026012806282213600_r52","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/35104560","article-title":"Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.","volume":"414","author":"De Smaele","year":"2001","journal-title":"Nature"},{"key":"2026012806282213600_r53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.cdd.4401154","article-title":"JNK: a killer on a transcriptional leash.","volume":"10","author":"Franzoso","year":"2003","journal-title":"Cell Death Differ."},{"key":"2026012806282213600_r54","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1038\/sj.onc.1204570","article-title":"NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B.","volume":"20","author":"Javelaud","year":"2001","journal-title":"Oncogene"},{"key":"2026012806282213600_r55","doi-asserted-by":"crossref","first-page":"18514","DOI":"10.1073\/pnas.0705316104","article-title":"Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis.","volume":"104","author":"Stathopoulos","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026012806282213600_r56","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1126\/science.274.5288.782","article-title":"An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.","volume":"274","author":"Beg","year":"1996","journal-title":"Science"},{"key":"2026012806282213600_r57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0092-8674(03)00757-8","article-title":"A JNK-dependent pathway is required for TNFalpha-induced apoptosis.","volume":"115","author":"Deng","year":"2003","journal-title":"Cell"},{"key":"2026012806282213600_r58","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.yexcr.2007.10.001","article-title":"Interferon-alpha induces transient upregulation of c-FLIP through NF-kappaB activation.","volume":"314","author":"Kanetaka","year":"2008","journal-title":"Exp. Cell Res."},{"key":"2026012806282213600_r59","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S1097-2765(03)00203-X","article-title":"JunD mediates survival signaling by the JNK signal transduction pathway.","volume":"11","author":"Lamb","year":"2003","journal-title":"Mol. Cell"},{"key":"2026012806282213600_r60","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.274.5288.787","article-title":"Suppression of TNF-alpha-induced apoptosis by NF-kappaB.","volume":"274","author":"Van Antwerp","year":"1996","journal-title":"Science"},{"key":"2026012806282213600_r61","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/7410","article-title":"Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.","volume":"5","author":"Wang","year":"1999","journal-title":"Nat. Med."},{"key":"2026012806282213600_r62","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.274.5288.784","article-title":"TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.","volume":"274","author":"Wang","year":"1996","journal-title":"Science"},{"key":"2026012806282213600_r63","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1126\/science.281.5383.1680","article-title":"NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.","volume":"281","author":"Wang","year":"1998","journal-title":"Science"},{"key":"2026012806282213600_r64","first-page":"G599","article-title":"Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis.","volume":"276","author":"Abreu-Martin","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2026012806282213600_r65","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4049\/jimmunol.160.1.134","article-title":"The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression.","volume":"160","author":"Faris","year":"1998","journal-title":"J. Immunol."},{"key":"2026012806282213600_r66","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.","volume":"288","author":"Tournier","year":"2000","journal-title":"Science"},{"key":"2026012806282213600_r67","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1128\/MCB.22.13.4929-4942.2002","article-title":"The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.","volume":"22","author":"Lei","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2026012806282213600_r68","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0960-9822(02)00547-X","article-title":"The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat.","volume":"6","author":"Zanke","year":"1996","journal-title":"Curr. Biol."},{"key":"2026012806282213600_r69","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1242\/jeb.018960","article-title":"Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart.","volume":"211","author":"Gaitanaki","year":"2008","journal-title":"J. Exp. Biol."},{"key":"2026012806282213600_r70","doi-asserted-by":"crossref","first-page":"L622","DOI":"10.1152\/ajplung.00477.2005","article-title":"NF-kappa B activation as a pathological mechanism of septic shock and inflammation.","volume":"290","author":"Liu","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2026012806282213600_r71","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.4049\/jimmunol.0900105","article-title":"A pivotal role of endothelial-specific NF-kappaB signaling in the pathogenesis of septic shock and septic vascular dysfunction.","volume":"183","author":"Ding","year":"2009","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/7\/3801\/62712072\/ji_0903191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/7\/3801\/62712072\/ji_0903191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:31:07Z","timestamp":1769599867000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/7\/3801\/8006851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":71,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,4,1]]},"published-print":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0903191","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,4]]},"published":{"date-parts":[[2010,4,1]]}}}