{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:41:00Z","timestamp":1791168060049,"version":"4.1.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The CTL response in HLA-B*27+ HIV-infected individuals is characterized by an immunodominant response to a conserved epitope in gag p24 (aa 263\u2013272, KRWIILGLNK; KK10). Mutations resulting in substitution of the arginine (R264) at position 2 of this epitope have been identified as escape mutations. Nineteen HLA-B*27+ long-term nonprogressors were identified from an Australian cohort with an average follow-up of 16 y following infection. Viral and host genetic factors impacting on disease progression were determined at multiple time points. Twelve of 19 had wild-type sequences at codon 264 at all time points; 7 of 19 carried CTL escape variants. Median viral load and CD4+ T cell counts were not significantly different between these groups at enrollment. Viral load, as judged by levels at their last visit (1,700 and 21,000 RNA copies\/ml, respectively; p = 0.01) or by time-weighted area under the curve was higher in the escape group (p = 0.02). Escape mutants at other HLA-B*27\u2013restricted epitopes were uncommon. Moreover, host polymorphisms, such as CCR5\u039432, CCR2-64I, and SDF1-3\u2032A, or breadth of TCR repertoire responding to KK10 did not segregate to wild-type or escape groups. Host and viral factors were examined for a relationship to viral load. The only factor to affect viral load was the presence of the R264 escape mutations at the immunodominant epitope. CTL escape at R264 in the KK10 epitope is a major determinant of subsequent viral load in these HLA-B*27+ individuals.<\/jats:p>","DOI":"10.4049\/jimmunol.0903227","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T05:24:38Z","timestamp":1291094678000},"page":"479-488","source":"Crossref","is-referenced-by-count":36,"title":["HIV Immune Escape at an Immunodominant Epitope in HLA-B*27\u2013Positive Individuals Predicts Viral Load Outcome"],"prefix":"10.1093","volume":"186","author":[{"given":"Palanee","family":"Ammaranond","sequence":"first","affiliation":[{"name":"Immunovirology Laboratory, St Vincent\u2019s Centre for Applied Medical Research , Darlinghurst"},{"name":"Department of Transfusion Medicine, Chulalongkorn University , Bangkok 10330 ,","place":["Thailand"]},{"name":"Chulalongkorn University Centenary Academic Development Project, Faculty of Allied Health Sciences, Chulalongkorn University , Bangkok 10330 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"van Bockel","sequence":"additional","affiliation":[{"name":"Immunovirology Laboratory, St Vincent\u2019s Centre for Applied Medical Research , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Petoumenos","sequence":"additional","affiliation":[{"name":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylin","family":"McMurchie","sequence":"additional","affiliation":[{"name":"East Sydney Doctors , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Finlayson","sequence":"additional","affiliation":[{"name":"Taylor Square Private Clinic , Sydney, New South Wales 2010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie G","family":"Middleton","sequence":"additional","affiliation":[{"name":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles P","family":"Davenport","sequence":"additional","affiliation":[{"name":"Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales , Kensington, New South Wales 2052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Venturi","sequence":"additional","affiliation":[{"name":"Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales , Kensington, New South Wales 2052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Immunovirology Laboratory, St Vincent\u2019s Centre for Applied Medical Research , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Gelgor","sequence":"additional","affiliation":[{"name":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Kaldor","sequence":"additional","affiliation":[{"name":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Cooper","sequence":"additional","affiliation":[{"name":"Immunovirology Laboratory, St Vincent\u2019s Centre for Applied Medical Research , Darlinghurst"},{"name":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Immunovirology Laboratory, St Vincent\u2019s Centre for Applied Medical Research , Darlinghurst"},{"name":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales , Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"2025032410543593400_r1","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1128\/JVI.78.13.7069-7078.2004","article-title":"Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection","volume":"78","author":"Allen","year":"2004","journal-title":"J. Virol."},{"key":"2025032410543593400_r2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nm0297-205","article-title":"Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus","volume":"3","author":"Borrow","year":"1997","journal-title":"Nat. Med."},{"key":"2025032410543593400_r3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1084\/jem.20031982","article-title":"Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection","volume":"199","author":"Draenert","year":"2004","journal-title":"J. Exp. Med."},{"key":"2025032410543593400_r4","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.1128\/JVI.78.16.8437-8445.2004","article-title":"Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population","volume":"78","author":"Furutsuki","year":"2004","journal-title":"J. Virol."},{"key":"2025032410543593400_r5","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nm0297-212","article-title":"Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS","volume":"3","author":"Goulder","year":"1997","journal-title":"Nat. Med."},{"key":"2025032410543593400_r6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1084\/jem.193.3.375","article-title":"Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses","volume":"193","author":"Kelleher","year":"2001","journal-title":"J. Exp. Med."},{"key":"2025032410543593400_r7","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1002\/eji.1830250720","article-title":"The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus","volume":"25","author":"Klenerman","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"2025032410543593400_r8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/369403a0","article-title":"Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants","volume":"369","author":"Klenerman","year":"1994","journal-title":"Nature"},{"key":"2025032410543593400_r9","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.270.5240.1360","article-title":"Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants","volume":"270","author":"Meier","year":"1995","journal-title":"Science"},{"key":"2025032410543593400_r10","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1073\/pnas.94.5.1890","article-title":"Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection","volume":"94","author":"Price","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032410543593400_r11","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/eji.1830270929","article-title":"Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides","volume":"27","author":"Sewell","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"2025032410543593400_r12","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1128\/JVI.78.3.1324-1332.2004","article-title":"Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection","volume":"78","author":"Yokomaku","year":"2004","journal-title":"J. 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Virol."},{"key":"2025032410543593400_r15","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1069660","article-title":"Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level","volume":"296","author":"Moore","year":"2002","journal-title":"Science"},{"key":"2025032410543593400_r16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1126\/science.272.5261.537","article-title":"Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection","volume":"272","author":"Wolinsky","year":"1996","journal-title":"Science"},{"key":"2025032410543593400_r17","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1128\/JVI.76.17.8757-8768.2002","article-title":"Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation","volume":"76","author":"Yusim","year":"2002","journal-title":"J. Virol."},{"key":"2025032410543593400_r18","doi-asserted-by":"crossref","first-page":"9216","DOI":"10.1128\/JVI.01041-08","article-title":"Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute\/early HIV-1 infection","volume":"82","author":"Brumme","year":"2008","journal-title":"J. Virol."},{"key":"2025032410543593400_r19","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/JVI.01545-08","article-title":"HLA-associated clinical progression correlates with epitope reversion rates in early human immunodeficiency virus infection","volume":"83","author":"Duda","year":"2009","journal-title":"J. Virol."},{"key":"2025032410543593400_r20","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.immuni.2004.10.010","article-title":"T cell receptor recognition motifs govern immune escape patterns in acute SIV infection","volume":"21","author":"Price","year":"2004","journal-title":"Immunity"},{"key":"2025032410543593400_r21","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1128\/JVI.01061-08","article-title":"Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1","volume":"83","author":"Wang","year":"2009","journal-title":"J. Virol."},{"key":"2025032410543593400_r22","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1084\/jem.20090365","article-title":"The first T cell response to transmitted\/founder virus contributes to the control of acute viremia in HIV-1 infection","volume":"206","author":"Goonetilleke","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025032410543593400_r23","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1128\/JVI.76.8.4108-4112.2002","article-title":"Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication","volume":"76","author":"Allen","year":"2002","journal-title":"J. Virol."},{"key":"2025032410543593400_r24","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1128\/JVI.77.13.7367-7375.2003","article-title":"Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys","volume":"77","author":"Barouch","year":"2003","journal-title":"J. Virol."},{"key":"2025032410543593400_r25","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.4049\/jimmunol.164.12.6474","article-title":"Simian immunodeficiency virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class I","volume":"164","author":"Chen","year":"2000","journal-title":"J. Immunol."},{"key":"2025032410543593400_r26","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/15224","article-title":"Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef","volume":"5","author":"Evans","year":"1999","journal-title":"Nat. Med."},{"key":"2025032410543593400_r27","doi-asserted-by":"crossref","first-page":"10064","DOI":"10.1128\/JVI.78.18.10064-10073.2004","article-title":"Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts","volume":"78","author":"Friedrich","year":"2004","journal-title":"J. Virol."},{"key":"2025032410543593400_r28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/336484a0","article-title":"HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides","volume":"336","author":"Nixon","year":"1988","journal-title":"Nature"},{"key":"2025032410543593400_r29","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.4049\/jimmunol.154.5.2189","article-title":"Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope","volume":"154","author":"Nietfield","year":"1995","journal-title":"J. Immunol."},{"key":"2025032410543593400_r30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00002030-200002180-00003","article-title":"Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection","volume":"14","author":"Wilson","year":"2000","journal-title":"AIDS"},{"key":"2025032410543593400_r31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1089\/aid.2005.21.395","article-title":"A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1","volume":"21","author":"Ammaranond","year":"2005","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"2025032410543593400_r32","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/35085576","article-title":"Evolution and transmission of stable CTL escape mutations in HIV infection","volume":"412","author":"Goulder","year":"2001","journal-title":"Nature"},{"key":"2025032410543593400_r33","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0092-8674(00)81823-1","article-title":"Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid","volume":"87","author":"Gamble","year":"1996","journal-title":"Cell"},{"key":"2025032410543593400_r34","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nsb0996-763","article-title":"Crystal structure of dimeric HIV-1 capsid protein","volume":"3","author":"Momany","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"2025032410543593400_r35","doi-asserted-by":"crossref","first-page":"12382","DOI":"10.1128\/JVI.01543-07","article-title":"Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication","volume":"81","author":"Schneidewind","year":"2007","journal-title":"J. Virol."},{"key":"2025032410543593400_r36","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.it.2006.09.007","article-title":"Hitting HIV where it hurts: an alternative approach to HIV vaccine design","volume":"27","author":"Altfeld","year":"2006","journal-title":"Trends Immunol."},{"key":"2025032410543593400_r37","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1073\/pnas.0408773102","article-title":"Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection","volume":"102","author":"Betts","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032410543593400_r38","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1126\/science.283.5408.1748","article-title":"HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage","volume":"283","author":"Carrington","year":"1999","journal-title":"Science"},{"key":"2025032410543593400_r39","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.4049\/jimmunol.162.11.6942","article-title":"New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS","volume":"162","author":"Hendel","year":"1999","journal-title":"J. Immunol."},{"key":"2025032410543593400_r40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nm0496-405","article-title":"Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection","volume":"2","author":"Kaslow","year":"1996","journal-title":"Nat. Med."},{"key":"2025032410543593400_r41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/aid.1998.14.117","article-title":"Predictors of progression in long-term nonprogressors","volume":"14","author":"Ashton","year":"1998","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"2025032410543593400_r42","first-page":"8","volume-title":"WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children.","author":"World Health Organization","year":"2007"},{"key":"2025032410543593400_r43","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1097\/00002030-199715000-00007","article-title":"Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection","volume":"11","author":"Stewart","year":"1997","journal-title":"AIDS"},{"key":"2025032410543593400_r44","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1096-9071(199905)58:1<54::AID-JMV8>3.0.CO;2-N","article-title":"Frequencies of SDF-1 chemokine, CCR-5, and CCR-2 chemokine receptor gene alleles conferring resistance to human immunodeficiency virus type 1 and AIDS in Kuwaitis","volume":"58","author":"Voevodin","year":"1999","journal-title":"J. Med. Virol."},{"key":"2025032410543593400_r45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jim.2007.07.016","article-title":"Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood","volume":"326","author":"van Bockel","year":"2007","journal-title":"J. Immunol. Methods"},{"key":"2025032410543593400_r46","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.4049\/jimmunol.168.6.3099","article-title":"A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape","volume":"168","author":"Douek","year":"2002","journal-title":"J. Immunol."},{"key":"2025032410543593400_r47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1468-1293.2008.00663.x","article-title":"Effect of nucleoside reverse transcriptase inhibitors on CD4 T-cell recovery in HIV-1-infected individuals receiving long-term fully suppressive combination antiretroviral therapy","volume":"10","author":"Byakwaga","year":"2009","journal-title":"HIV Med."},{"key":"2025032410543593400_r48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jim.2007.01.019","article-title":"Methods for comparing the diversity of samples of the T cell receptor repertoire","volume":"321","author":"Venturi","year":"2007","journal-title":"J. Immunol. Methods"},{"key":"2025032410543593400_r49","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1002\/eji.1830211051","article-title":"In vivo persistence of a HIV-1-encoded HLA-B27-restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity","volume":"21","author":"Meyerhans","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"2025032410543593400_r50","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1128\/JVI.74.22.10581-10588.2000","article-title":"Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression","volume":"74","author":"Rhodes","year":"2000","journal-title":"J. Virol."},{"key":"2025032410543593400_r51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1399-0039.2008.01183.x","article-title":"The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1\/3\/4\/5, and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens","volume":"73","author":"Holdsworth","year":"2009","journal-title":"Tissue Antigens"},{"key":"2025032410543593400_r52","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nature07746","article-title":"Adaptation of HIV-1 to human leukocyte antigen class I","volume":"458","author":"Kawashima","year":"2009","journal-title":"Nature"},{"key":"2025032410543593400_r53","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03113","article-title":"Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA","volume":"432","author":"Kiepiela","year":"2004","journal-title":"Nature"},{"key":"2025032410543593400_r54","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1128\/JVI.00320-10","article-title":"Additive contribution of HLA class I alleles in the immune control of HIV-1 infection","volume":"84","author":"Leslie","year":"2010","journal-title":"J. Virol."},{"key":"2025032410543593400_r55","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.4049\/jimmunol.170.4.1925","article-title":"Associations of MHC ancestral haplotypes with resistance\/susceptibility to AIDS disease development","volume":"170","author":"Flores-Villanueva","year":"2003","journal-title":"J. Immunol."},{"key":"2025032410543593400_r56","first-page":"37","article-title":"HLA-B35 is associated with accelerated progression to AIDS","volume":"5","author":"Itescu","year":"1992","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"2025032410543593400_r57","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.1128\/JVI.78.16.8927-8930.2004","article-title":"Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child","volume":"78","author":"Feeney","year":"2004","journal-title":"J. Virol."},{"key":"2025032410543593400_r58","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/354453a0","article-title":"Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition","volume":"354","author":"Phillips","year":"1991","journal-title":"Nature"},{"key":"2025032410543593400_r59","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1371\/journal.pmed.0030403","article-title":"HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1","volume":"3","author":"Altfeld","year":"2006","journal-title":"PLoS Med."},{"key":"2025032410543593400_r60","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1084\/jem.185.8.1423","article-title":"Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation","volume":"185","author":"Goulder","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025032410543593400_r61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1084\/jem.193.2.181","article-title":"Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection","volume":"193","author":"Goulder","year":"2001","journal-title":"J. Exp. Med."},{"key":"2025032410543593400_r62","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1126\/science.270.5238.988","article-title":"Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients","volume":"270","author":"Deacon","year":"1995","journal-title":"Science"},{"key":"2025032410543593400_r63","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/QAD.0b013e3283021a8c","article-title":"Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection","volume":"22","author":"Brumme","year":"2008","journal-title":"AIDS"},{"key":"2025032410543593400_r64","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/JVI.01471-08","article-title":"HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1","volume":"83","author":"Miura","year":"2009","journal-title":"J. Virol."},{"key":"2025032410543593400_r65","first-page":"77","volume-title":"HIV Management in Australia: A Guide for Clinical Care.","author":"Vujovic","year":"2009"},{"key":"2025032410543593400_r66","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20070784","article-title":"Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover","volume":"204","author":"Almeida","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025032410543593400_r67","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1084\/jem.20061865","article-title":"A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells","volume":"204","author":"Lichterfeld","year":"2007","journal-title":"J. Exp. 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