{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:30:45Z","timestamp":1791052245042,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immune activation is a feature of dengue hemorrhagic fever (DHF) and CD8+ T cell responses in particular have been suggested as having a role in the vasculopathy that characterizes this disease. By phenotyping CD8+ T cells (CD38+\/HLA-DR+, CD38+\/Ki-67+, or HLA-DR+\/Ki-67+) in serial blood samples from children with dengue, we found no evidence of increased CD8+ T cell activation prior to the commencement of resolution of viremia or hemoconcentration. Investigations with MHC class I tetramers to detect NS3133\u2013142-specific CD8+ T cells in two independent cohorts of children suggested the commencement of hemoconcentration and thrombocytopenia in DHF patients generally begins before the appearance of measurable frequencies of NS3133\u2013142-specific CD8+ T cells. The temporal mismatch between the appearance of measurable surface activated or NS3133\u2013142-specific CD8+ T cells suggests that these cells are sequestered at sites of infection, have phenotypes not detected by our approach, or that other mechanisms independent of CD8+ T cells are responsible for early triggering of capillary leakage in children with DHF.<\/jats:p>","DOI":"10.4049\/jimmunol.0903262","type":"journal-article","created":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T22:44:47Z","timestamp":1273704287000},"page":"7281-7287","source":"Crossref","is-referenced-by-count":78,"title":["Timing of CD8+ T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengue"],"prefix":"10.1093","volume":"184","author":[{"given":"Nguyen Thi Phuong","family":"Dung","sequence":"first","affiliation":[{"name":"Oxford University Clinical Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh Thi Le","family":"Duyen","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Van Thuy","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran","family":"Van Ngoc","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Van Vinh","family":"Chau","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Tinh","family":"Hien","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Rowland-Jones","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Dong","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Farrar","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit"},{"name":"Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford , Oxford,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Wills","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit"},{"name":"Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford , Oxford,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron P","family":"Simmons","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit"},{"name":"Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford , Oxford,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,6,15]]},"reference":[{"key":"2026012806343121900_r1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/01.inf.0000258612.26743.10","article-title":"Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study.","volume":"26","author":"Srikiatkhachorn","year":"2007","journal-title":"Pediatr. 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