{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:46:45Z","timestamp":1792525605987,"version":"4.5.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T00:00:00Z","timestamp":1262131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-33 is constitutively expressed in epithelial barrier tissues, such as skin. Although increased expression of IL-33\/IL-33R has been correlated with fibrotic disorders, such as scleroderma and progressive systemic sclerosis, the direct consequences of IL-33 release in skin has not been reported. To determine the effects of dysregulated IL-33 signaling in skin, we administered IL-33 s.c. and monitored its effects at the injection site. Administration of IL-33 resulted in IL-33R\u2013dependent accumulation of eosinophils, CD3+ lymphocytes, F4\/80+ mononuclear cells, increased expression of IL-13 mRNA, and the development of cutaneous fibrosis. Consistent with extensive cutaneous tissue remodeling, IL-33 resulted in significant modulation of a number of extracellular matrix-associated genes, including collagen VI, collagen III, and tissue inhibitor of metalloproteases-1. We establish that IL-33\u2013induced fibrosis requires IL-13 using IL-13 knockout mice and eosinophils using \u0394dblGATA mice. We show that bone marrow-derived eosinophils secrete IL-13 in response to IL-33 stimulation, suggesting that eosinophil-derived IL-13 may promote IL-33\u2013induced cutaneous fibrosis. Collectively, our results identify IL-33 as a previously unrecognized profibrotic mediator in skin and highlight the cellular and molecular pathways by which this pathology develops.<\/jats:p>","DOI":"10.4049\/jimmunol.0903306","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T22:01:23Z","timestamp":1262210483000},"page":"1526-1535","source":"Crossref","is-referenced-by-count":201,"title":["IL-33 Induces IL-13\u2013Dependent Cutaneous Fibrosis"],"prefix":"10.1093","volume":"184","author":[{"given":"Andrew L","family":"Rankin","sequence":"first","affiliation":[{"name":"Department of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B","family":"Mumm","sequence":"additional","affiliation":[{"name":"Department of Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrill K","family":"McClanahan","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A","family":"Bourne","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H","family":"Pierce","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Pharmacology, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Kastelein","sequence":"additional","affiliation":[{"name":"Department of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Pflanz","sequence":"additional","affiliation":[{"name":"Department of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,30]]},"reference":[{"key":"2026012808091437700_r1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis.","volume":"214","author":"Wynn","year":"2008","journal-title":"J. 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