{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:45:46Z","timestamp":1791071146855,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28\u2013B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4\u2013B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4\u2013B7 interaction in vivo confers the susceptibility of experimental autoimmune myocarditis to CD28\u2212\/\u2212 mice or increases the severity of experimental autoimmune myocarditis in wild-type mice. The enhanced disease susceptibility is mediated by heightened Th17 responses. With these results, we are the first to demonstrate that CTLA-4\u2013B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.0903369","type":"journal-article","created":{"date-parts":[[2010,7,3]],"date-time":"2010-07-03T03:22:24Z","timestamp":1278127344000},"page":"1375-1378","source":"Crossref","is-referenced-by-count":100,"title":["Cutting Edge: CTLA-4\u2013B7 Interaction Suppresses Th17 Cell Differentiation"],"prefix":"10.1093","volume":"185","author":[{"given":"Haiyan","family":"Ying","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai"},{"name":"Graduate School of the Chinese Academy of Sciences , Shanghai"},{"name":"Section of Nephrology, Department of Medicine, University of Chicago , Chicago, IL 60637"},{"name":"Committee on Immunology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Yang","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Medicine, University of Chicago , Chicago, IL 60637"},{"name":"Committee on Immunology, University of Chicago , Chicago, IL 60637"},{"name":"Department of Pediatrics, Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Medicine, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenping","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Medicine, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Medicine, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xie","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Medicine, University of Chicago , Chicago, IL 60637"},{"name":"Committee on Immunology, University of Chicago , Chicago, IL 60637"},{"name":"Committee on Molecular Medicine, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"key":"2025032411425838700_r1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni0407-345","article-title":"T(H)-17 cells in the circle of immunity and autoimmunity","volume":"8","author":"Bettelli","year":"2007","journal-title":"Nat. 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