{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:58Z","timestamp":1791262618954,"version":"4.1.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL-22 is a member of the IL-10 cytokine family and signals through a heterodimeric receptor composed of the common IL-10R2 subunit and the IL-22R subunit. IL-10 and IL-22 both activate the STAT3 signaling pathway; however, in contrast to IL-10, relatively little is known about IL-22 in the host response to infection. In this study, using IL-22\u2212\/\u2212 mice, neutralizing Abs to IL-22, or both, we show that IL-22 is dispensable for the development of immunity to the opportunistic pathogens Toxoplasma gondii and Mycobacterium avium when administered via the i.p. or i.v. route, respectively. IL-22 also played little to no role in aerosol infections with Mycobacterium tuberculosis and in granuloma formation and hepatic fibrosis following chronic percutaneous infections with the helminth parasite Schistosoma mansoni. A marked pathogenic role for IL-22 was, however, identified in toxoplasmosis when infections were established by the natural oral route. Anti\u2013IL-22 Ab-treated mice developed significantly less intestinal pathology than control Ab-treated mice even though both groups displayed similar parasite burdens. The decreased gut pathology was associated with reduced IL-17A, IL-17F, TNF-\u03b1, and IFN-\u03b3 expression. In contrast to the prior observations of IL-22 protective effects in the gut, these distinct findings with oral T. gondii infection demonstrate that IL-22 also has the potential to contribute to pathogenic inflammation in the intestine. The IL-22 pathway has emerged as a possible target for control of inflammation in certain autoimmune diseases. Our findings suggest that few if any infectious complications would be expected with the suppression of IL-22 signaling.<\/jats:p>","DOI":"10.4049\/jimmunol.0903416","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T03:13:55Z","timestamp":1268277235000},"page":"4378-4390","source":"Crossref","is-referenced-by-count":124,"title":["Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections"],"prefix":"10.1093","volume":"184","author":[{"given":"Mark S","family":"Wilson","sequence":"first","affiliation":[{"name":"Immunopathogensis Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl G","family":"Feng","sequence":"additional","affiliation":[{"name":"Immunobiology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"Barber","sequence":"additional","affiliation":[{"name":"Immunobiology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Yarovinsky","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center at Dallas , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen W","family":"Cheever","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Sher","sequence":"additional","affiliation":[{"name":"Immunobiology Section"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grigg","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Collins","sequence":"additional","affiliation":[{"name":"Wyeth Research-Inflammation , Cambridge, MA 02140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Fouser","sequence":"additional","affiliation":[{"name":"Wyeth Research-Inflammation , Cambridge, MA 02140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Wynn","sequence":"additional","affiliation":[{"name":"Immunopathogensis Section"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,15]]},"reference":[{"key":"2025032603592942200_r1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nri1153","article-title":"Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators.","volume":"3","author":"Renauld","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"2025032603592942200_r2","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.jmb.2008.07.046","article-title":"IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22.","volume":"382","author":"Wu","year":"2008","journal-title":"J. Mol. Biol."},{"key":"2025032603592942200_r3","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.4049\/jimmunol.168.11.5397","article-title":"Cutting edge: immune cells as sources and targets of the IL-10 family members?","volume":"168","author":"Wolk","year":"2002","journal-title":"J. Immunol."},{"key":"2025032603592942200_r4","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.","volume":"203","author":"Liang","year":"2006","journal-title":"J. Exp. Med."},{"key":"2025032603592942200_r5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.immuni.2009.06.020","article-title":"Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals.","volume":"31","author":"Martin","year":"2009","journal-title":"Immunity"},{"key":"2025032603592942200_r6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.","volume":"31","author":"Sutton","year":"2009","journal-title":"Immunity"},{"key":"2025032603592942200_r7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2009.06.008","article-title":"Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity.","volume":"31","author":"Colonna","year":"2009","journal-title":"Immunity"},{"key":"2025032603592942200_r8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1767","article-title":"Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.","volume":"10","author":"Duhen","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025032603592942200_r9","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","article-title":"Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells.","volume":"10","author":"Trifari","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025032603592942200_r10","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1074\/jbc.M007837200","article-title":"Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes.","volume":"276","author":"Kotenko","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2025032603592942200_r11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","article-title":"IL-22 increases the innate immunity of tissues.","volume":"21","author":"Wolk","year":"2004","journal-title":"Immunity"},{"key":"2025032603592942200_r12","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/eji.200535503","article-title":"IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.","volume":"36","author":"Wolk","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"2025032603592942200_r13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nm1710","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.","volume":"14","author":"Aujla","year":"2008","journal-title":"Nat. Med."},{"key":"2025032603592942200_r14","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.4049\/jimmunol.174.6.3695","article-title":"IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes.","volume":"174","author":"Boniface","year":"2005","journal-title":"J. Immunol."},{"key":"2025032603592942200_r15","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity.","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"2025032603592942200_r16","first-page":"1092","article-title":"Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.","volume":"159","author":"Nograles","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"2025032603592942200_r17","first-page":"534","article-title":"IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.","volume":"118","author":"Sugimoto","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2025032603592942200_r18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-009-0457-0","article-title":"IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not.","volume":"87","author":"Wolk","year":"2009","journal-title":"J. Mol. Med."},{"key":"2025032603592942200_r19","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens.","volume":"14","author":"Zheng","year":"2008","journal-title":"Nat. Med."},{"key":"2025032603592942200_r20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","article-title":"Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.","volume":"29","author":"Zenewicz","year":"2008","journal-title":"Immunity"},{"key":"2025032603592942200_r21","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing.","volume":"206","author":"Pickert","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025032603592942200_r22","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1128\/IAI.01564-06","article-title":"Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis.","volume":"75","author":"Weber","year":"2007","journal-title":"Infect. Immun."},{"key":"2025032603592942200_r23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.","volume":"445","author":"Zheng","year":"2007","journal-title":"Nature"},{"key":"2025032603592942200_r24","first-page":"597","article-title":"IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation.","volume":"118","author":"Ma","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2025032603592942200_r25","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/art.24220","article-title":"Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL\/6 mice.","volume":"60","author":"Geboes","year":"2009","journal-title":"Arthritis Rheum."},{"key":"2025032603592942200_r26","first-page":"43","article-title":"Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3.","volume":"1","author":"Pan","year":"2004","journal-title":"Cell. Mol. Immunol."},{"key":"2025032603592942200_r27","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation.","volume":"39","author":"Radaeva","year":"2004","journal-title":"Hepatology"},{"key":"2025032603592942200_r28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.","volume":"27","author":"Zenewicz","year":"2007","journal-title":"Immunity"},{"key":"2025032603592942200_r29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ni1544","article-title":"Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.","volume":"9","author":"Ramalingam","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025032603592942200_r30","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1172\/JCI31546","article-title":"IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.","volume":"117","author":"Wilson","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2025032603592942200_r31","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1128\/IAI.70.12.6672-6679.2002","article-title":"Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis.","volume":"70","author":"Feng","year":"2002","journal-title":"Infect. Immun."},{"key":"2025032603592942200_r32","doi-asserted-by":"crossref","first-page":"G1019","DOI":"10.1152\/ajpgi.00239.2006","article-title":"IL-22-mediated liver cell regeneration is abrogated by SOCS-1\/3 overexpression in vitro.","volume":"292","author":"Brand","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025032603592942200_r33","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1073\/pnas.171303198","article-title":"A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist.","volume":"98","author":"Xu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032603592942200_r34","first-page":"250","article-title":"Profiles of the mRNA expression by macrophages infected with Mycobacterium leprae and Mycobacterium avium complex.","volume":"70","author":"Shimizu","year":"2002","journal-title":"Int. J. Lepr. Other Mycobact. Dis."},{"key":"2025032603592942200_r35","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.4049\/jimmunol.162.6.3512","article-title":"Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL\/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB\/c mice.","volume":"162","author":"Schl\u00fcter","year":"1999","journal-title":"J. Immunol."},{"key":"2025032603592942200_r36","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.4049\/jimmunol.164.12.6406","article-title":"IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis.","volume":"164","author":"Hoffmann","year":"2000","journal-title":"J. Immunol."},{"key":"2025032603592942200_r37","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.4049\/jimmunol.164.5.2585","article-title":"Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent.","volume":"164","author":"Fallon","year":"2000","journal-title":"J. Immunol."},{"key":"2025032603592942200_r38","doi-asserted-by":"crossref","first-page":"734","DOI":"10.2307\/3285752","article-title":"Schistosoma mansoni: IL-4 is necessary for concomitant immunity in mice.","volume":"85","author":"Brunet","year":"1999","journal-title":"J. Parasitol."},{"key":"2025032603592942200_r39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","article-title":"An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response.","volume":"104","author":"Chiaramonte","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2025032603592942200_r40","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","article-title":"Disseminated tuberculosis in interferon gamma gene-disrupted mice.","volume":"178","author":"Cooper","year":"1993","journal-title":"J. Exp. Med."},{"key":"2025032603592942200_r41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1053\/spid.2002.127198","article-title":"Latent tuberculosis: models, mechanisms, and novel prospects for eradication.","volume":"13","author":"Riska","year":"2002","journal-title":"Semin. Pediatr. Infect. Dis."},{"key":"2025032603592942200_r42","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1046\/j.1365-2567.2002.01511.x","article-title":"Reactivation of latent tuberculosis by an inhibitor of inducible nitric oxide synthase in an aerosol murine model.","volume":"107","author":"Botha","year":"2002","journal-title":"Immunology"},{"key":"2025032603592942200_r43","doi-asserted-by":"crossref","first-page":"ii54","DOI":"10.1136\/ard.61.suppl_2.ii54","article-title":"Protection against tuberculosis: cytokines, T cells, and macrophages.","volume":"61","author":"Kaufmann","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"2025032603592942200_r44","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.4049\/jimmunol.171.6.3110","article-title":"Reactivation of latent tuberculosis infection in TNF-deficient mice.","volume":"171","author":"Botha","year":"2003","journal-title":"J. Immunol."},{"key":"2025032603592942200_r45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ni.1684","article-title":"RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.","volume":"10","author":"Sanos","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025032603592942200_r46","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.4049\/jimmunol.178.9.5973","article-title":"IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn\u2019s disease.","volume":"178","author":"Wolk","year":"2007","journal-title":"J. Immunol."},{"key":"2025032603592942200_r47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor.","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"2025032603592942200_r48","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.","volume":"157","author":"Gazzinelli","year":"1996","journal-title":"J. Immunol."},{"key":"2025032603592942200_r49","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1172\/JCI9918","article-title":"IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.","volume":"105","author":"Boussiotis","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2025032603592942200_r50","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.4049\/jimmunol.151.10.5425","article-title":"IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections.","volume":"151","author":"Denis","year":"1993","journal-title":"J. Immunol."},{"key":"2025032603592942200_r51","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4049\/jimmunol.158.1.315","article-title":"T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.","volume":"158","author":"Murray","year":"1997","journal-title":"J. Immunol."},{"key":"2025032603592942200_r52","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.4049\/jimmunol.169.11.6343","article-title":"In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL\/6 mice.","volume":"169","author":"Turner","year":"2002","journal-title":"J. Immunol."},{"key":"2025032603592942200_r53","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1073\/pnas.0400983101","article-title":"Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.","volume":"101","author":"Verreck","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032603592942200_r54","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.4049\/jimmunol.168.5.2383","article-title":"IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.","volume":"168","author":"Schopf","year":"2002","journal-title":"J. Immunol."},{"key":"2025032603592942200_r55","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00109-009-0448-1","article-title":"IL-22: a critical mediator in mucosal host defense.","volume":"87","author":"Aujla","year":"2009","journal-title":"J. Mol. Med."},{"key":"2025032603592942200_r56","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1002\/eji.200838655","article-title":"IL-22 and inflammation: leukin\u2019 through a glass onion.","volume":"38","author":"Zenewicz","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"2025032603592942200_r57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/mi.2008.26","article-title":"IL-22 in mucosal immunity.","volume":"1","author":"Ouyang","year":"2008","journal-title":"Mucosal Immunol."},{"key":"2025032603592942200_r58","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/clin.1996.0118","article-title":"Th1 and Th2 in human diseases.","volume":"80","author":"Romagnani","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"2025032603592942200_r59","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ni1105-1069","article-title":"TH-17: a giant step from TH1 and TH2.","volume":"6","author":"Wynn","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025032603592942200_r60","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.175.6.3920","article-title":"Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17.","volume":"175","author":"Rutitzky","year":"2005","journal-title":"J. Immunol."},{"key":"2025032603592942200_r61","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.4049\/jimmunol.177.3.1416","article-title":"Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection.","volume":"177","author":"Cruz","year":"2006","journal-title":"J. Immunol."},{"key":"2025032603592942200_r62","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection.","volume":"177","author":"Lockhart","year":"2006","journal-title":"J. Immunol."},{"key":"2025032603592942200_r63","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/IAI.73.1.617-621.2005","article-title":"Interleukin-17\/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection.","volume":"73","author":"Kelly","year":"2005","journal-title":"Infect. Immun."},{"key":"2025032603592942200_r64","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni1376","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.","volume":"7","author":"Stumhofer","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032603592942200_r65","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1590\/S0074-02762006000900052","article-title":"CD4 T cells producing pro-inflammatory interleukin-17 mediate high pathology in schistosomiasis.","volume":"101","author":"Rutitzky","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"2025032603592942200_r66","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1017\/S0031182009005708","article-title":"The saga of schistosome migration and attrition.","volume":"136","author":"Wilson","year":"2009","journal-title":"Parasitology"},{"key":"2025032603592942200_r67","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1128\/IAI.73.9.5782-5788.2005","article-title":"Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs.","volume":"73","author":"Happel","year":"2005","journal-title":"Infect. Immun."},{"key":"2025032603592942200_r68","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.","volume":"8","author":"Khader","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025032603592942200_r69","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1086\/592448","article-title":"Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses.","volume":"198","author":"Qiu","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2025032603592942200_r70","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4049\/jimmunol.180.3.1962","article-title":"Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.","volume":"180","author":"Scriba","year":"2008","journal-title":"J. Immunol."},{"key":"2025032603592942200_r71","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.4049\/jimmunol.157.9.4045","article-title":"In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.","volume":"157","author":"Scharton-Kersten","year":"1996","journal-title":"J. Immunol."},{"key":"2025032603592942200_r72","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.smim.2007.11.006","article-title":"Negative regulation of Th17 responses.","volume":"19","author":"Stumhofer","year":"2007","journal-title":"Semin. Immunol."},{"key":"2025032603592942200_r73","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.184.2.597","article-title":"Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii.","volume":"184","author":"Liesenfeld","year":"1996","journal-title":"J. Exp. Med."},{"key":"2025032603592942200_r74","doi-asserted-by":"crossref","first-page":"G827","DOI":"10.1152\/ajpgi.00513.2005","article-title":"IL-22 is increased in active Crohn\u2019s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration.","volume":"290","author":"Brand","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025032603592942200_r75","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/j.gastro.2005.06.071","article-title":"Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.","volume":"129","author":"Andoh","year":"2005","journal-title":"Gastroenterology"},{"key":"2025032603592942200_r76","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.4049\/jimmunol.168.6.2988","article-title":"Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogen.","volume":"168","author":"Mennechet","year":"2002","journal-title":"J. Immunol."},{"key":"2025032603592942200_r77","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1136\/gut.2003.028225","article-title":"CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn\u2019s disease.","volume":"53","author":"Connor","year":"2004","journal-title":"Gut"},{"key":"2025032603592942200_r78","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/ibd.20315","article-title":"Linking genetic susceptibility to Crohn\u2019s disease with Th17 cell function: IL-22 serum levels are increased in Crohn\u2019s disease and correlate with disease activity and IL23R genotype status.","volume":"14","author":"Schmechel","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"2025032603592942200_r79","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ibd.20079","article-title":"Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease.","volume":"13","author":"te Velde","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"2025032603592942200_r80","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.4049\/jimmunol.158.6.2689","article-title":"IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences.","volume":"158","author":"Polentarutti","year":"1997","journal-title":"J. Immunol."},{"key":"2025032603592942200_r81","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1084\/jem.20070634","article-title":"TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production.","volume":"204","author":"Goldszmid","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025032603592942200_r82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00712.x","article-title":"Th17 cytokines and their emerging roles in inflammation and autoimmunity.","volume":"226","author":"Fouser","year":"2008","journal-title":"Immunol. Rev."},{"key":"2025032603592942200_r83","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.autrev.2008.07.011","article-title":"Screening for tuberculosis infection prior to initiation of anti-TNF therapy.","volume":"8","author":"Lalvani","year":"2008","journal-title":"Autoimmun. Rev."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/8\/4378\/62719261\/ji_0903416.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/8\/4378\/62719261\/ji_0903416.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T10:29:10Z","timestamp":1743244150000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/8\/4378\/8013332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":83,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0903416","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,4]]},"published":{"date-parts":[[2010,4]]}}}