{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:50:01Z","timestamp":1789980601531,"version":"4.0.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Osteoclasts are resident cells of the bone that are primarily involved in the physiological and pathological remodeling of this tissue. Mature osteoclasts are multinucleated giant cells that are generated from the fusion of circulating precursors originating from the monocyte\/macrophage lineage. During inflammatory bone conditions in vivo, de novo osteoclastogenesis is observed but it is currently unknown whether, besides increased osteoclast differentiation from undifferentiated precursors, other cell types can generate a multinucleated giant cell phenotype with bone resorbing activity. In this study, an animal model of calvaria-induced aseptic osteolysis was used to analyze possible bone resorption capabilities of dendritic cells (DCs). We determined by FACS analysis and confocal microscopy that injected GFP-labeled immature DCs were readily recruited to the site of osteolysis. Upon recruitment, the cathepsin K-positive DCs were observed in bone-resorbing pits. Additionally, chromosomal painting identified nuclei from female DCs, previously injected into a male recipient, among the nuclei of giant cells at sites of osteolysis. Finally, osteolysis was also observed upon recruitment of CD11c-GFP conventional DCs in Csf1r\u2212\/\u2212 mice, which exhibit a severe depletion of resident osteoclasts and tissue macrophages. Altogether, our analysis indicates that DCs may have an important role in bone resorption associated with various inflammatory diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.0903560","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T01:26:54Z","timestamp":1277515614000},"page":"1485-1491","source":"Crossref","is-referenced-by-count":38,"title":["Dendritic Cell-Mediated In Vivo Bone Resorption"],"prefix":"10.1093","volume":"185","author":[{"given":"Radhashree","family":"Maitra","sequence":"first","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , New York, NY 10461"},{"name":"Department of Orthopedic Surgery, Montefiore Medical Center , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Follenzi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Yaghoobian","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Montefiore Medical Center , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Montagna","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , New York, NY 10461"},{"name":"Department of Molecular Genetics, Albert Einstein College of Medicine , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Merlin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira S","family":"Cannizzo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Hardin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Montefiore Medical Center , New York, NY 10461"},{"name":"Division of Rheumatology, Department of Medicine, Albert Einstein College of Medicine , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Cobelli","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Montefiore Medical Center , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Richard","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Developmental Molecular Biology, Albert Einstein College of Medicine , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Santambrogio","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine , New York, NY 10461"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , New York, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"key":"2025032411442842300_r1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/08916930701693180","article-title":"Osteoclasts - the innate immune cells of the bone","volume":"41","author":"Wu","year":"2008","journal-title":"Autoimmunity"},{"key":"2025032411442842300_r2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/08916930701694543","article-title":"Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss","volume":"41","author":"Abu-Amer","year":"2008","journal-title":"Autoimmunity"},{"key":"2025032411442842300_r3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-0-387-72009-8_6","article-title":"Immunologic regulation of bone development","volume":"602","author":"Horowitz","year":"2007","journal-title":"Adv. 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