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They show that \u03b3\u03b4 T cells engage in immune responses both early and late, that they can function both polyclonally and as peripherally selected clones, and that they can be effector cells and immune regulators. They also suggest that functional development of \u03b3\u03b4 T cells occurs stepwise in thymus and periphery, and that it is governed by \u03b3\u03b4 TCR-signaling and other signals. Finally, they indicate that \u03b3\u03b4 T cell functions often segregate with TCR-defined subsets, in contrast to conventional T cells. From the functional studies in mice and other animal models, \u03b3\u03b4 T cells emerge as a distinct lymphocyte population with a unique and broad functional repertoire, and with important roles in Ab responses, inflammation and tissue repair. They also are revealed as a potentially useful target for immune intervention.<\/jats:p>","DOI":"10.4049\/jimmunol.0903679","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T17:04:54Z","timestamp":1270487094000},"page":"4055-4061","source":"Crossref","is-referenced-by-count":59,"title":["Analysis of \u03b3\u03b4 T Cell Functions in the Mouse"],"prefix":"10.1093","volume":"184","author":[{"given":"Willi K","family":"Born","sequence":"first","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Health , Denver, CO 80206"},{"name":"University of Colorado at Denver Health Sciences Center , Denver, CO 80220"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinan","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Nankai University , Tianjin,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Soo","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine and Medical Research Institute, Chungbuk National University , Cheongju,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Doheny Eye Institute, University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Health , Denver, CO 80206"},{"name":"University of Colorado at Denver Health Sciences Center , Denver, CO 80220"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,15]]},"reference":[{"key":"2026012808073781200_r1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.1135344","article-title":"Regulation of \u03b3\u03b4 versus \u03b1\u03b2 T lymphocyte differentiation by the transcription factor SOX13.","volume":"315","author":"Melichar","year":"2007","journal-title":"Science"},{"key":"2026012808073781200_r2","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.4049\/jimmunol.0804249","article-title":"Id3 restricts the developmental potential of \u03b3 \u03b4 lineage during thymopoiesis.","volume":"182","author":"Ueda-Hayakawa","year":"2009","journal-title":"J. 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