{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:42:46Z","timestamp":1790376166703,"version":"4.1.0"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":5473,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HL79164"],"award-info":[{"award-number":["RO1HL79164"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["0855555D"],"award-info":[{"award-number":["0855555D"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["RO1AI060632"],"award-info":[{"award-number":["RO1AI060632"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["RO1AI059267"],"award-info":[{"award-number":["RO1AI059267"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A robust innate immune response is essential to the protection of all vertebrates from infection, but it often comes with the price tag of acute inflammation. If unchecked, a runaway inflammatory response can cause significant tissue damage, resulting in myriad disorders, such as dermatitis, toxic shock, cardiovascular disease, acute pelvic and arthritic inflammatory diseases, and various infections. To prevent such pathologies, cells have evolved mechanisms to rapidly and specifically shut off these beneficial inflammatory activities before they become detrimental. Our review of recent literature, including our own work, reveals that the most dominant and common mechanism is translational silencing, in which specific regulatory proteins or complexes are recruited to cis-acting RNA structures in the untranslated regions of single or multiple mRNAs that code for the inflammatory protein(s). Enhancement of the silencing function may constitute a novel pharmacological approach to prevent immunity-related inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.0903778","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T19:33:33Z","timestamp":1269027213000},"page":"3311-3319","source":"Crossref","is-referenced-by-count":81,"title":["Translation Control: A Multifaceted Regulator of Inflammatory Response"],"prefix":"10.1093","volume":"184","author":[{"given":"Barsanjit","family":"Mazumder","sequence":"first","affiliation":[{"name":"Department of Biology, Geology and Environmental Science, Center for Gene Regulation in Health and Disease, College of Science, Cleveland State University , Cleveland, OH 44115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, Cleveland Clinic Foundation Lerner Research Institute , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailen","family":"Barik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama , Mobile, AL 36688"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"2026041420284845400_r1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0968-0004(03)00002-1","article-title":"Translational control by the 3\u2032-UTR: the ends specify the means.","volume":"28","author":"Mazumder","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"2026041420284845400_r2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2009.01.042","article-title":"Regulation of translation initiation in eukaryotes: mechanisms and biological targets.","volume":"136","author":"Sonenberg","year":"2009","journal-title":"Cell"},{"key":"2026041420284845400_r3","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation.","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"2026041420284845400_r4","volume-title":"Robbins and Cotran's Pathologic Basis of Disease","author":"Kumar","year":"2004","edition":"7th Ed."},{"key":"2026041420284845400_r5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation.","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"2026041420284845400_r6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd1383","article-title":"Inflammatory resolution: new opportunities for drug discovery.","volume":"3","author":"Gilroy","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"2026041420284845400_r7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0092-8674(02)00642-6","article-title":"Gene-specific regulation by general translation factors.","volume":"108","author":"Dever","year":"2002","journal-title":"Cell"},{"key":"2026041420284845400_r8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nrm1618","article-title":"Translational control in stress and apoptosis.","volume":"6","author":"Holcik","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026041420284845400_r9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.molcel.2007.11.018","article-title":"New modes of translational control in development, behavior, and disease.","volume":"28","author":"Sonenberg","year":"2007","journal-title":"Mol. Cell"},{"key":"2026041420284845400_r10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ni1584","article-title":"Post-transcriptional control of cytokine production.","volume":"9","author":"Anderson","year":"2008","journal-title":"Nat. Immunol."},{"key":"2026041420284845400_r11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.tibs.2009.03.004","article-title":"The GAIT system: a gatekeeper of inflammatory gene expression.","volume":"34","author":"Mukhopadhyay","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"2026041420284845400_r12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/10408369009105897","article-title":"Interleukins and tumor necrosis factor in inflammation.","volume":"28","author":"Warren","year":"1990","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"2026041420284845400_r13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1189\/jlb.0704400","article-title":"Synergistic effect of SCF and TNF-\u03b1 on the up-regulation of cell-surface expression of ICAM-1 on human leukemic mast cell line (HMC)-1 cells.","volume":"78","author":"Tsang","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2026041420284845400_r14","doi-asserted-by":"crossref","first-page":"11192","DOI":"10.1074\/jbc.M412997200","article-title":"Chromatin modification and the endothelial-specific activation of the E-selectin gene.","volume":"280","author":"Edelstein","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r15","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.3754653","article-title":"Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.","volume":"232","author":"Beutler","year":"1986","journal-title":"Science"},{"key":"2026041420284845400_r16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.171.2.465","article-title":"Endotoxin-responsive sequences control cachectin\/tumor necrosis factor biosynthesis at the translational level.","volume":"171","author":"Han","year":"1990","journal-title":"J. Exp. Med."},{"key":"2026041420284845400_r17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80038-2","article-title":"Impaired on\/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.","volume":"10","author":"Kontoyiannis","year":"1999","journal-title":"Immunity"},{"key":"2026041420284845400_r18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.immuni.2005.06.009","article-title":"The Mnks are novel components in the control of TNF \u03b1 biosynthesis and phosphorylate and regulate hnRNP A1.","volume":"23","author":"Buxad\u00e9","year":"2005","journal-title":"Immunity"},{"key":"2026041420284845400_r19","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1093\/emboj\/19.15.4154","article-title":"TIA-1 is a translational silencer that selectively regulates the expression of TNF-\u03b1.","volume":"19","author":"Piecyk","year":"2000","journal-title":"EMBO J."},{"key":"2026041420284845400_r20","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1074\/jbc.274.4.2322","article-title":"Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor \u03b1 mRNA.","volume":"274","author":"Gueydan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r21","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1083\/jcb.147.7.1431","article-title":"RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.","volume":"147","author":"Kedersha","year":"1999","journal-title":"J. Cell Biol."},{"key":"2026041420284845400_r22","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1084\/jem.20030616","article-title":"Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.","volume":"198","author":"Dixon","year":"2003","journal-title":"J. Exp. Med."},{"key":"2026041420284845400_r23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1097-2765(03)00012-1","article-title":"Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.","volume":"11","author":"Mukhopadhyay","year":"2003","journal-title":"Mol. Cell"},{"key":"2026041420284845400_r24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0092-8674(01)00597-9","article-title":"The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.","volume":"107","author":"Oh","year":"2001","journal-title":"Cell"},{"key":"2026041420284845400_r25","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1074\/jbc.M203526200","article-title":"Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR).","volume":"278","author":"Yu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r26","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1128\/MCB.25.21.9520-9531.2005","article-title":"Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.","volume":"25","author":"L\u00f3pez de Silanes","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r27","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.molcel.2005.08.007","article-title":"HuR as a negative posttranscriptional modulator in inflammation.","volume":"19","author":"Katsanou","year":"2005","journal-title":"Mol. Cell"},{"key":"2026041420284845400_r28","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1125676","article-title":"Type 1 interferons and the virus-host relationship: a lesson in d\u00e9tente.","volume":"312","author":"Garc\u00eda-Sastre","year":"2006","journal-title":"Science"},{"key":"2026041420284845400_r29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature06730","article-title":"Translational control of the innate immune response through IRF-7.","volume":"452","author":"Colina","year":"2008","journal-title":"Nature"},{"key":"2026041420284845400_r30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.immuni.2008.08.012","article-title":"The TSC-mTOR signaling pathway regulates the innate inflammatory response.","volume":"29","author":"Weichhart","year":"2008","journal-title":"Immunity"},{"key":"2026041420284845400_r31","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.it.2009.02.002","article-title":"The multiple facets of mTOR in immunity.","volume":"30","author":"Weichhart","year":"2009","journal-title":"Trends Immunol."},{"key":"2026041420284845400_r32","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1093\/emboj\/20.14.3760","article-title":"Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.","volume":"20","author":"Kontoyiannis","year":"2001","journal-title":"EMBO J."},{"key":"2026041420284845400_r33","doi-asserted-by":"crossref","first-page":"8260","DOI":"10.4049\/jimmunol.175.12.8260","article-title":"Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism.","volume":"175","author":"N\u00e9meth","year":"2005","journal-title":"J. Immunol."},{"key":"2026041420284845400_r34","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.4049\/jimmunol.169.4.2204","article-title":"Role of IL-10 for induction of anemia during inflammation.","volume":"169","author":"Tilg","year":"2002","journal-title":"J. Immunol."},{"key":"2026041420284845400_r35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ni.1603","article-title":"Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.","volume":"9","author":"Sinclair","year":"2008","journal-title":"Nat. Immunol."},{"key":"2026041420284845400_r36","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1016\/S0021-9258(18)53755-8","article-title":"Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1\/S-phase growth arrest in T lymphocytes.","volume":"268","author":"Morice","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08155","article-title":"mTOR regulates memory CD8 T-cell differentiation.","volume":"460","author":"Araki","year":"2009","journal-title":"Nature"},{"key":"2026041420284845400_r38","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2009.04.014","article-title":"The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.","volume":"30","author":"Delgoffe","year":"2009","journal-title":"Immunity"},{"key":"2026041420284845400_r39","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2009.12.003","article-title":"The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation.","author":"Gulen","year":"2010","journal-title":"Immunity"},{"key":"2026041420284845400_r40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/347669a0","article-title":"Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES.","volume":"347","author":"Schall","year":"1990","journal-title":"Nature"},{"key":"2026041420284845400_r41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1172\/JCI0215336","article-title":"A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.","volume":"110","author":"Nikolcheva","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2026041420284845400_r42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1074-7613(00)80010-2","article-title":"RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.","volume":"10","author":"Song","year":"1999","journal-title":"Immunity"},{"key":"2026041420284845400_r43","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1073\/pnas.0401901101","article-title":"Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs.","volume":"101","author":"Lindemann","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.biochem.69.1.419","article-title":"Platelet-activating factor and related lipid mediators.","volume":"69","author":"Prescott","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"2026041420284845400_r45","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/89759","article-title":"Lipid mediator class switching during acute inflammation: signals in resolution.","volume":"2","author":"Levy","year":"2001","journal-title":"Nat. Immunol."},{"key":"2026041420284845400_r46","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/ni1056","article-title":"Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway.","volume":"5","author":"Karp","year":"2004","journal-title":"Nat. Immunol."},{"key":"2026041420284845400_r47","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0092-8674(00)80241-X","article-title":"mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3\u2032 end.","volume":"89","author":"Ostareck","year":"1997","journal-title":"Cell"},{"key":"2026041420284845400_r48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(01)00212-4","article-title":"Lipoxygenase mRNA silencing in erythroid differentiation: The 3\u2019UTR regulatory complex controls 60S ribosomal subunit joining.","volume":"104","author":"Ostareck","year":"2001","journal-title":"Cell"},{"key":"2026041420284845400_r49","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/MCB.22.13.4535-4543.2002","article-title":"c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.","volume":"22","author":"Ostareck-Lederer","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.immunol.22.012703.104711","article-title":"The dynamic life of natural killer cells.","volume":"22","author":"Yokoyama","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"2026041420284845400_r51","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.immuni.2007.04.010","article-title":"Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.","volume":"26","author":"Fehniger","year":"2007","journal-title":"Immunity"},{"key":"2026041420284845400_r52","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1046\/j.1538-7836.2003.00304.x","article-title":"The evolving role of platelets in inflammation.","volume":"1","author":"Weyrich","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"2026041420284845400_r53","doi-asserted-by":"crossref","first-page":"10284","DOI":"10.1073\/pnas.181201398","article-title":"Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes.","volume":"98","author":"Mahoney","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r54","doi-asserted-by":"crossref","first-page":"5556","DOI":"10.1073\/pnas.95.10.5556","article-title":"Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets.","volume":"95","author":"Weyrich","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r55","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1096\/fj.01-0690hyp","article-title":"Regional manifestations and control of the immune system.","volume":"16","author":"Saadi","year":"2002","journal-title":"FASEB J."},{"key":"2026041420284845400_r56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","article-title":"HIF-1\u03b1 is essential for myeloid cell-mediated inflammation.","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"key":"2026041420284845400_r57","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1073\/pnas.91.14.6496","article-title":"Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3\u2032 enhancer.","volume":"91","author":"Firth","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r58","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","article-title":"Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.","volume":"269","author":"Semenza","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r59","doi-asserted-by":"crossref","first-page":"29083","DOI":"10.1074\/jbc.270.49.29083","article-title":"Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences.","volume":"270","author":"Ebert","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r60","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1091\/mbc.02-02-0017","article-title":"Hypoxia-inducible factor-1\u03b1 mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia.","volume":"13","author":"Lang","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"2026041420284845400_r61","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1158\/0008-5472.CAN-04-1437","article-title":"Functional integrity of nuclear factor kappaB, phosphatidylinositol 3\u2032-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1alpha.","volume":"64","author":"Zhou","year":"2004","journal-title":"Cancer Res."},{"key":"2026041420284845400_r62","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1128\/MCB.22.21.7405-7416.2002","article-title":"Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.","volume":"22","author":"Koumenis","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-5793(99)00185-4","article-title":"Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes.","volume":"446","author":"Tinton","year":"1999","journal-title":"FEBS Lett."},{"key":"2026041420284845400_r64","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature02870","article-title":"Unlocking the potential of the human genome with RNA interference.","volume":"431","author":"Hannon","year":"2004","journal-title":"Nature"},{"key":"2026041420284845400_r65","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response.","volume":"104","author":"O\u2019Connell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r66","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.4049\/jimmunol.179.8.5082","article-title":"Modulation of miR-155 and miR-125b levels following lipopolysaccharide\/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock.","volume":"179","author":"Tili","year":"2007","journal-title":"J. Immunol."},{"key":"2026041420284845400_r67","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1073\/pnas.0810909106","article-title":"Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals.","volume":"106","author":"Bazzoni","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r68","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.4049\/jimmunol.180.8.5689","article-title":"Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells.","volume":"180","author":"Perry","year":"2008","journal-title":"J. Immunol."},{"key":"2026041420284845400_r69","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1074\/jbc.M311498200","article-title":"Interleukin 1 activates STAT3\/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism.","volume":"279","author":"Yoshida","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r70","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r71","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1196\/annals.1352.026","article-title":"Transcription factor NF-kappaB: a sensor for smoke and stress signals.","volume":"1056","author":"Ahn","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2026041420284845400_r72","doi-asserted-by":"crossref","first-page":"21596","DOI":"10.1074\/jbc.M910087199","article-title":"Regulation of SOCS-1 expression by translational repression.","volume":"275","author":"Gregorieff","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2026041420284845400_r73","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1073\/pnas.94.20.10895","article-title":"Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium.","volume":"94","author":"Firestein","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r74","doi-asserted-by":"crossref","first-page":"10025","DOI":"10.1073\/pnas.152333199","article-title":"Regional analysis of p53 mutations in rheumatoid arthritis synovium.","volume":"99","author":"Yamanishi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r75","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2337\/diabetes.54.5.1423","article-title":"Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function.","volume":"54","author":"Zheng","year":"2005","journal-title":"Diabetes"},{"key":"2026041420284845400_r76","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1093\/emboj\/16.13.4117","article-title":"Participation of the human p53 3\u2019UTR in translational repression and activation following gamma-irradiation.","volume":"16","author":"Fu","year":"1997","journal-title":"EMBO J."},{"key":"2026041420284845400_r77","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1073\/pnas.1432104100","article-title":"RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.","volume":"100","author":"Mazan-Mamczarz","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041420284845400_r78","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.1128\/MCB.23.20.7083-7095.2003","article-title":"Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells.","volume":"23","author":"Galb\u00e1n","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r79","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1046\/j.1523-1755.2003.00077.x","article-title":"IL-18 translational inhibition restricts IFN-\u03b3 expression in crescentic glomerulonephritis.","volume":"64","author":"Garcia","year":"2003","journal-title":"Kidney Int."},{"key":"2026041420284845400_r80","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(02)00616-5","article-title":"Human interferon-\u03b3 mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR.","volume":"108","author":"Ben-Asouli","year":"2002","journal-title":"Cell"},{"key":"2026041420284845400_r81","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-\u03b3: an overview of signals, mechanisms and functions.","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2026041420284845400_r82","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1128\/MCB.19.10.6898","article-title":"Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: role of the 3\u2032 untranslated region.","volume":"19","author":"Mazumder","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r83","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1128\/MCB.21.19.6440-6449.2001","article-title":"Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G.","volume":"21","author":"Mazumder","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r84","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0092-8674(03)00773-6","article-title":"Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.","volume":"115","author":"Mazumder","year":"2003","journal-title":"Cell"},{"key":"2026041420284845400_r85","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1128\/MCB.23.5.1509-1519.2003","article-title":"Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3\u2032 untranslated region.","volume":"23","author":"Sampath","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r86","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2004.09.030","article-title":"Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.","volume":"119","author":"Sampath","year":"2004","journal-title":"Cell"},{"key":"2026041420284845400_r87","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1261\/rna.694007","article-title":"Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation.","volume":"13","author":"Chaudhuri","year":"2007","journal-title":"RNA"},{"key":"2026041420284845400_r88","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molcel.2006.11.028","article-title":"L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control.","volume":"25","author":"Kapasi","year":"2007","journal-title":"Mol. Cell"},{"key":"2026041420284845400_r89","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/MCB.00824-08","article-title":"Genome-wide polysome profiling reveals an inflammation-responsive posttranscriptional operon in gamma interferon-activated monocytes.","volume":"29","author":"Vyas","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"2026041420284845400_r90","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/0929866013409517","article-title":"Ceruloplasmin, the unique multi-copper oxidase of vertebrates.","volume":"8","author":"Musci","year":"2001","journal-title":"Protein Pept. Lett."},{"key":"2026041420284845400_r91","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.molcel.2009.05.028","article-title":"Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity.","volume":"35","author":"Arif","year":"2009","journal-title":"Mol. Cell"},{"key":"2026041420284845400_r92","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.molcel.2008.09.019","article-title":"DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.","volume":"32","author":"Mukhopadhyay","year":"2008","journal-title":"Mol. Cell"},{"key":"2026041420284845400_r93","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1038\/sj.emboj.7601774","article-title":"A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity.","volume":"26","author":"Ray","year":"2007","journal-title":"EMBO J."},{"key":"2026041420284845400_r94","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nature07598","article-title":"A stress-responsive RNA switch regulates VEGFA expression.","volume":"457","author":"Ray","year":"2009","journal-title":"Nature"},{"key":"2026041420284845400_r95","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrg2111","article-title":"RNA regulons: coordination of post-transcriptional events.","volume":"8","author":"Keene","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"2026041420284845400_r96","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S1097-2765(02)00559-2","article-title":"Eukaryotic mRNPs may represent posttranscriptional operons.","volume":"9","author":"Keene","year":"2002","journal-title":"Mol. Cell"},{"key":"2026041420284845400_r97","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.it.2006.04.002","article-title":"Fine-tuning leukocyte responses: towards a chemokine \u2018interactome\u2019.","volume":"27","author":"Weber","year":"2006","journal-title":"Trends Immunol."},{"key":"2026041420284845400_r98","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1160\/TH07-01-0046","article-title":"Chemokines and thrombogenicity.","volume":"97","author":"Lambert","year":"2007","journal-title":"Thromb. Haemost."},{"key":"2026041420284845400_r99","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis.","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"2026041420284845400_r100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/84209","article-title":"Chemokines and disease.","volume":"2","author":"Gerard","year":"2001","journal-title":"Nat. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/7\/3311\/62719876\/ji_0903778.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/7\/3311\/62719876\/ji_0903778.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:56:39Z","timestamp":1776214599000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/7\/3311\/8007461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":100,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.0903778","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,4]]},"published":{"date-parts":[[2010,4,1]]}}}