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In this study, we found, although this is so under steady state conditions, under inflammatory conditions monocyte-derived DC (mDC) became a major cell type producing IL-12. Depletion of either type of DC resulted in reduced production of IL-12 in vivo. For CD8+ DC, IL-12 production could be stimulated by various pathways viz. signaling through MyD88, Trif, or nucleotide-binding oligomerization domain (Nod)-like receptors. In contrast, for mDC, IL-12 production was mainly dependent on MyD88 signaling. Thus, conventional DCs and mDCs use different pathways to regulate IL-12 production.<\/jats:p>","DOI":"10.4049\/jimmunol.0903793","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T22:27:24Z","timestamp":1279578444000},"page":"2125-2133","source":"Crossref","is-referenced-by-count":43,"title":["Resident and Monocyte-Derived Dendritic Cells Become Dominant IL-12 Producers under Different Conditions and Signaling Pathways"],"prefix":"10.1093","volume":"185","author":[{"given":"Yifan","family":"Zhan","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuekang","family":"Xu","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Seah","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L","family":"Brady","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M","family":"Carrington","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Cheers","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben A","family":"Croker","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A","family":"Villadangos","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Lew","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,15]]},"reference":[{"key":"2025032411465637400_r1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/icb.2008.3","article-title":"The cell biology of cross-presentation and the role of dendritic cell subsets","volume":"86","author":"Lin","year":"2008","journal-title":"Immunol. 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