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Latently infected persons, of which there are estimated to be ~2 billion in the world, represent an enormous reservoir of potential reactivation TB, which can spread to other people. The immunology of TB is complex and multifaceted. Identifying the immune mechanisms that lead to control of initial infection and prevent reactivation of latent infection is crucial to combating this disease.<\/jats:p>","DOI":"10.4049\/jimmunol.0903856","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T01:37:09Z","timestamp":1277084229000},"page":"15-22","source":"Crossref","is-referenced-by-count":385,"title":["Understanding Latent Tuberculosis: A Moving Target"],"prefix":"10.1093","volume":"185","author":[{"given":"Philana Ling","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center , Pittsburgh, PA 15224"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnne L","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine , Pittsburgh, PA 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"2025032411364170600_r1","doi-asserted-by":"crossref","DOI":"10.30875\/94694cca-en","volume-title":"WHO Report 2009: Global Tuberculosis Control. 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