{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:30:01Z","timestamp":1768437001519,"version":"3.49.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Interaction between the nervous and immune systems greatly contributes to inflammatory disease. In organs at the interface between our body and the environment, the sensory neuropeptide substance P (SP) is one key mediator of an acute local stress response through neurogenic inflammation but may also alter cytokine balance and dendritic cell (DC) function. Using a combined murine allergic inflammation\/noise stress model with C57BL\/6 mice, we show in this paper that SP\u2014released during repeated stress exposure\u2014has the capacity to markedly attenuate inflammation. In particular, repeated stress exposure prior to allergen sensitization increases DC-nerve fiber contacts, enhances DC migration and maturation, alters cytokine balance, and increases levels of IL-2 and T regulatory cell numbers in local lymph nodes and inflamed tissue in a neurokinin 1-SP-receptor (neurokinin-1 receptor)-dependent manner. Concordantly, allergic inflammation is significantly reduced after repeated stress exposure. We conclude that SP\/repeated stress prior to immune activation acts protolerogenically and thereby beneficially in inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.0903878","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T04:23:44Z","timestamp":1292905424000},"page":"848-855","source":"Crossref","is-referenced-by-count":49,"title":["Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation"],"prefix":"10.1093","volume":"186","author":[{"given":"Sanja","family":"Pavlovic","sequence":"first","affiliation":[{"name":"University-Medicine Charit\u00e9, Charit\u00e9 Center 12 for Internal Medicine and Dermatology , D-10117 Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Liezmann","sequence":"additional","affiliation":[{"name":"University-Medicine Charit\u00e9, Charit\u00e9 Center 12 for Internal Medicine and Dermatology , D-10117 Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M","family":"Blois","sequence":"additional","affiliation":[{"name":"University-Medicine Charit\u00e9, Charit\u00e9 Center 12 for Internal Medicine and Dermatology , D-10117 Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricarda","family":"Joachim","sequence":"additional","affiliation":[{"name":"University-Medicine Charit\u00e9, Charit\u00e9 Center 12 for Internal Medicine and Dermatology , D-10117 Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, University Giessen , D-35392 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Romani","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Innsbruck Medical University , A-6020 Innsbruck ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burghard F","family":"Klapp","sequence":"additional","affiliation":[{"name":"University-Medicine Charit\u00e9, Charit\u00e9 Center 12 for Internal Medicine and Dermatology , D-10117 Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva M J","family":"Peters","sequence":"additional","affiliation":[{"name":"University-Medicine Charit\u00e9, Charit\u00e9 Center 12 for Internal Medicine and Dermatology , D-10117 Berlin ,","place":["Germany"]},{"name":"Department of Psychosomatic Medicine, University Giessen , D-35392 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,15]]},"reference":[{"key":"2025032410583891000_r1","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/archderm.139.11.1479","article-title":"Modern aspects of cutaneous neurogenic inflammation","volume":"139","author":"Steinhoff","year":"2003","journal-title":"Arch. 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