{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:39:30Z","timestamp":1779251970584,"version":"3.51.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mice infected with the neurotropic JHM strain of mouse hepatitis virus (JHMV) develop acute and chronic demyelinating diseases with histopathological similarities to multiple sclerosis. The process of demyelination is largely immune-mediated, as immunodeficient mice (RAG1\u2212\/\u2212 mice) do not develop demyelination upon infection; however, demyelination develops if these mice are reconstituted with either JHMV-immune CD4 or CD8 T cells. Because myelin destruction is a consequence of the inflammatory response associated with virus clearance, we reasoned that decreasing the amount of inflammation would diminish clinical disease and demyelination. Given that regulatory T cells (Tregs) have potent anti-inflammatory effects, we adoptively transferred Tregs into infected C57BL\/6 and RAG1\u2212\/\u2212 mice. In both instances, transfer of Tregs decreased weight loss, clinical scores, and demyelination. Transferred Tregs were not detected in the CNS of infected RAG1\u2212\/\u2212 mice, but rather appeared to mediate their effects in the draining cervical lymph nodes. We show that Tregs dampen the inflammatory response mediated by transferred JHMV-immune splenocytes in infected RAG1\u2212\/\u2212 mice by decreasing T cell proliferation, dendritic cell activation, and proinflammatory cytokine\/chemokine production, without inducing apoptosis. By extension, decreasing inflammation, whether by Treg transfer or by otherwise enhancing the anti-inflammatory milieu, could contribute to improved clinical outcomes in patients with virus-induced demyelination.<\/jats:p>","DOI":"10.4049\/jimmunol.0903918","type":"journal-article","created":{"date-parts":[[2010,3,6]],"date-time":"2010-03-06T03:29:03Z","timestamp":1267846143000},"page":"4391-4400","source":"Crossref","is-referenced-by-count":68,"title":["Regulatory T Cells Inhibit T Cell Proliferation and Decrease Demyelination in Mice Chronically Infected with a Coronavirus"],"prefix":"10.1093","volume":"184","author":[{"given":"Kathryn","family":"Trandem","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Anghelina","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"},{"name":"Institute for Tissue Transplantation and Immunology, Jinan University , Guangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Perlman","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Immunology"},{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,4,15]]},"reference":[{"key":"2025032603594355600_r1","first-page":"1057","article-title":"Control of regulatory T cell development by the transcription factor Foxp3.","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"2025032603594355600_r2","first-page":"689","article-title":"Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.","volume":"10","author":"Feuerer","year":"2009","journal-title":"Nat. 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