{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:18:06Z","timestamp":1779160686362,"version":"3.51.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neurocysticercosis (NCC) due to infection with Taenia solium is a major cause of epilepsy worldwide. Larval degeneration, which may follow antiparasitic treatment, results in clinical symptoms due to inflammatory cell influx. Mechanisms regulating this are not well understood, but chemokines have a key role. Stimulation of human monocytes by cyst Ags from NCC-infected pigs showed that scolex and membrane Ags drive CXCL8 and CCL2 secretion. Antiparasitic treatment of pigs increased CXCL8 in response to brain, but not muscle, cyst Ags. Cyst-fluid Ags did not elicit monocyte chemokine secretion, inhibited LPS-induced CXCL8 by up to 89%, but did not alter CCL2 secretion. This effect was inhibited by anti\u2013IL-10 Abs. Plasma CXCL8, TNF-\u03b1, IL-10, eotaxin, IL-1, IL-1ra, soluble IL-1R-II, and soluble TNFR-I and -II levels were evaluated in 167 NCC patients. Patients had lower plasma CXCL8 and TNF-\u03b1 concentrations than control subjects. In summary, larval Ags from brain and muscle cysts differentially regulate chemokine secretion. Cyst-fluid inhibits CXCL8, and this is blocked by anti\u2013IL-10 Abs. CXCL8 concentrations are decreased in patient plasma. Following anti-parasitic therapy, scolex and membrane Ags are exposed, and cyst fluid is decreased, leading to inflammatory cell influx. Taken together, the cellular, porcine, and human data may explain, in part, why NCC is usually asymptomatic but may cause proinflammatory symptoms, particularly following treatment.<\/jats:p>","DOI":"10.4049\/jimmunol.0904158","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T02:42:49Z","timestamp":1284000169000},"page":"4478-4484","source":"Crossref","is-referenced-by-count":14,"title":["Mechanisms Regulating Monocyte CXCL8 Secretion in Neurocysticercosis and the Effect of Antiparasitic Therapy"],"prefix":"10.1093","volume":"185","author":[{"given":"Jasim","family":"Uddin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Immunity, Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College London , London ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando E","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia , Lima ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H","family":"Gilman","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia , Lima ,","place":["Peru"]},{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette H","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunity, Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College London , London ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia , Lima ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlton A W","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunity, Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College London , London ,","place":["United Kingdom"]},{"name":"Universidad Peruana Cayetano Heredia , Lima ,","place":["Peru"]},{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G","family":"Remick","sequence":"additional","affiliation":[{"name":"Department of Pathology, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector H","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia , Lima ,","place":["Peru"]},{"name":"Instituto National de Ciencias Neurologicas , Lima ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon S","family":"Friedland","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunity, Wellcome Trust Centre for Clinical Tropical Medicine, Imperial College London , London ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"2025032411581346200_r1","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1371\/journal.pntd.0000300","article-title":"The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination","volume":"2","author":"Hotez","year":"2008","journal-title":"PLoS Negl. 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