{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:32:51Z","timestamp":1767961971527,"version":"3.49.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although many studies have shown that pulmonary surfactant protein (SP)-A functions in innate immunity, fewer studies have addressed its role in adaptive immunity and allergic hypersensitivity. We hypothesized that SP-A modulates the phenotype and prevalence of dendritic cells (DCs) and CD4+ T cells to inhibit Th2-associated inflammatory indices associated with allergen-induced inflammation. In an OVA model of allergic hypersensitivity, SP-A\u2212\/\u2212 mice had greater eosinophilia, Th2-associated cytokine levels, and IgE levels compared with wild-type counterparts. Although both OVA-exposed groups had similar proportions of CD86+ DCs and Foxp3+ T regulatory cells, the SP-A\u2212\/\u2212 mice had elevated proportions of CD4+ activated and effector memory T cells in their lungs compared with wild-type mice. Ex vivo recall stimulation of CD4+ T cell pools demonstrated that cells from the SP-A\u2212\/\u2212 OVA mice had the greatest proliferative and IL-4\u2013producing capacity, and this capability was attenuated with exogenous SP-A treatment. Additionally, tracking proliferation in vivo demonstrated that CD4+ activated and effector memory T cells expanded to the greatest extent in the lungs of SP-A\u2212\/\u2212 OVA mice. Taken together, our data suggested that SP-A influences the prevalence, types, and functions of CD4+ T cells in the lungs during allergic inflammation and that SP deficiency modifies the severity of inflammation in allergic hypersensitivity conditions like asthma.<\/jats:p>","DOI":"10.4049\/jimmunol.0904190","type":"journal-article","created":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T04:06:05Z","timestamp":1295669165000},"page":"2842-2849","source":"Crossref","is-referenced-by-count":26,"title":["Lung Effector Memory and Activated CD4+ T Cells Display Enhanced Proliferation in Surfactant Protein A-Deficient Mice during Allergen-Mediated Inflammation"],"prefix":"10.1093","volume":"186","author":[{"given":"Amy M","family":"Pastva","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center , Durham, NC 27710"},{"name":"Division of Physical Therapy, Duke University Medical Center , Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sambuddho","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Giamberardino","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Hsia","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernice","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D","family":"Sempowski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center , Durham, NC 27710"},{"name":"Department of Medicine, Human Vaccine Institute, Duke University Medical Center , Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo Rae","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"key":"2025032411100853300_r1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1165\/ajrcmb.19.2.140","article-title":"Collectins and pulmonary host defense","volume":"19","author":"Crouch","year":"1998","journal-title":"Am. 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