{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:08:34Z","timestamp":1781665714559,"version":"3.54.5"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Upon transfer into T cell-deficient hosts, naive CD8+ T cells typically undergo lymphopenia-induced proliferation (LIP, also called homeostatic proliferation) and develop the phenotypic and functional characteristics of memory CD8+ T cells. However, the capacity of T cells with self-peptide\/MHC specificity to respond in this way has not been intensively studied. We examined pmel-1 TCR transgenic CD8+ T cells that are specific for an epitope from gp100, a protein expressed by melanoma cells and normal melanocytes. Despite their self-specificity, naive pmel-1 cells were inefficient at LIP in typical lymphopenic hosts. In CD132 (common \u03b3-chain)-deficient hosts, pmel-1 CD8+ T cells underwent extensive proliferation, but, surprisingly, the majority of these cells retained certain naive phenotypic traits (CD44low, CD122low) rather than acquiring the expected central-memory phenotype. Following LIP, pmel-1 T cells acquired the capacity to control B16F10 tumor growth, but only in common \u03b3-chain\u2013deficient host mice. Together, these data suggest that LIP does not always favor expansion of self-specific CD8 T cells and that sustained extensive lymphopenia is required for such cells to exhibit tumor control.<\/jats:p>","DOI":"10.4049\/jimmunol.1000109","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T22:21:05Z","timestamp":1271283665000},"page":"5604-5611","source":"Crossref","is-referenced-by-count":17,"title":["Self-Specific CD8+ T Cells Maintain a Semi-Naive State Following Lymphopenia-Induced Proliferation"],"prefix":"10.1093","volume":"184","author":[{"given":"Lisa D S","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota , Minneapolis, MN 55414"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C","family":"Jameson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota , Minneapolis, MN 55414"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,5,15]]},"reference":[{"key":"2026012806280824400_r1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells.","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"2026012806280824400_r2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/ni1326","article-title":"The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells.","volume":"7","author":"Hamilton","year":"2006","journal-title":"Nat. Immunol."},{"key":"2026012806280824400_r3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1074-7613(00)80092-8","article-title":"The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery.","volume":"11","author":"Ernst","year":"1999","journal-title":"Immunity"},{"key":"2026012806280824400_r4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1074-7613(00)80093-X","article-title":"Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts.","volume":"11","author":"Goldrath","year":"1999","journal-title":"Immunity"},{"key":"2026012806280824400_r5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4049\/jimmunol.172.1.40","article-title":"A role for TCR affinity in regulating naive T cell homeostasis.","volume":"172","author":"Kieper","year":"2004","journal-title":"J. Immunol."},{"key":"2026012806280824400_r6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.20050359","article-title":"The timing of TCR alpha expression critically influences T cell development and selection.","volume":"202","author":"Baldwin","year":"2005","journal-title":"J. Exp. Med."},{"key":"2026012806280824400_r7","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.4049\/jimmunol.180.8.5320","article-title":"The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15.","volume":"180","author":"Ramsey","year":"2008","journal-title":"J. Immunol."},{"key":"2026012806280824400_r8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.188.2.277","article-title":"gp100\/pmel 17 is a murine tumor rejection antigen: induction of \u201cself\u201d-reactive, tumoricidal T cells using high-affinity, altered peptide ligand.","volume":"188","author":"Overwijk","year":"1998","journal-title":"J. Exp. Med."},{"key":"2026012806280824400_r9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nri1842","article-title":"Adoptive immunotherapy for cancer: building on success.","volume":"6","author":"Gattinoni","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2026012806280824400_r10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ncponc0666","article-title":"Increased intensity lymphodepletion and adoptive immunotherapy\u2013how far can we go?","volume":"3","author":"Muranski","year":"2006","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"2026012806280824400_r11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1172\/JCI30414","article-title":"Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.","volume":"117","author":"Wrzesinski","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2026012806280824400_r12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection.","volume":"76","author":"Hogquist","year":"1994","journal-title":"Cell"},{"key":"2026012806280824400_r13","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.4049\/jimmunol.166.9.5515","article-title":"Il-12 enhances CD8 T cell homeostatic expansion.","volume":"166","author":"Kieper","year":"2001","journal-title":"J. Immunol."},{"key":"2026012806280824400_r14","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/nprot.2007.296","article-title":"Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester.","volume":"2","author":"Quah","year":"2007","journal-title":"Nat. Protoc."},{"key":"2026012806280824400_r15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.coi.2007.04.015","article-title":"Cytokines and T-cell homeostasis.","volume":"19","author":"Boyman","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"2026012806280824400_r16","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.4049\/jimmunol.174.5.2591","article-title":"CD8+ T cell immunity against a tumor\/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.","volume":"174","author":"Antony","year":"2005","journal-title":"J. Immunol."},{"key":"2026012806280824400_r17","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1084\/jem.20020033","article-title":"Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells.","volume":"195","author":"Goldrath","year":"2002","journal-title":"J. Exp. Med."},{"key":"2026012806280824400_r18","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.0600240103","article-title":"Converting IL-15 to a superagonist by binding to soluble IL-15Ralpha.","volume":"103","author":"Rubinstein","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026012806280824400_r19","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.4049\/jimmunol.177.9.6072","article-title":"Combined IL-15\/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.","volume":"177","author":"Stoklasek","year":"2006","journal-title":"J. Immunol."},{"key":"2026012806280824400_r20","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ni1512","article-title":"\u2018Coreceptor tuning\u2019: cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.","volume":"8","author":"Park","year":"2007","journal-title":"Nat. Immunol."},{"key":"2026012806280824400_r21","doi-asserted-by":"crossref","first-page":"13306","DOI":"10.1073\/pnas.96.23.13306","article-title":"Homeostatic expansion and phenotypic conversion of na\u00efve T cells in response to self peptide\/MHC ligands.","volume":"96","author":"Kieper","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026012806280824400_r22","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1126\/science.1900951","article-title":"Peripheral selection of the T cell repertoire.","volume":"251","author":"Rocha","year":"1991","journal-title":"Science"},{"key":"2026012806280824400_r23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","article-title":"Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.","volume":"2","author":"Cao","year":"1995","journal-title":"Immunity"},{"key":"2026012806280824400_r24","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1172\/JCI24480","article-title":"Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.","volume":"115","author":"Gattinoni","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2026012806280824400_r25","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1326","article-title":"Host-reactive CD8+ memory stem cells in graft-versus-host disease.","volume":"11","author":"Zhang","year":"2005","journal-title":"Nat. Med."},{"key":"2026012806280824400_r26","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nm.1982","article-title":"Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.","volume":"15","author":"Gattinoni","year":"2009","journal-title":"Nat. Med."},{"key":"2026012806280824400_r27","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/eji.200838959","article-title":"Mice deficient in stem cell antigen-1 (Sca1, Ly-6A\/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection.","volume":"39","author":"Whitmire","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2026012806280824400_r28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4049\/jimmunol.179.1.120","article-title":"IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells.","volume":"179","author":"Sandau","year":"2007","journal-title":"J. Immunol."},{"key":"2026012806280824400_r29","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1084\/jem.20061805","article-title":"Antiviral CD4+ memory T cells are IL-15 dependent.","volume":"204","author":"Purton","year":"2007","journal-title":"J. Exp. Med."},{"key":"2026012806280824400_r30","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1084\/jem.20020066","article-title":"Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells.","volume":"195","author":"Tan","year":"2002","journal-title":"J. Exp. Med."},{"key":"2026012806280824400_r31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(91)90164-T","article-title":"Ablation of \u201ctolerance\u201d and induction of diabetes by virus infection in viral antigen transgenic mice.","volume":"65","author":"Ohashi","year":"1991","journal-title":"Cell"},{"key":"2026012806280824400_r32","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4049\/jimmunol.0901199","article-title":"Constitutive activation of Wnt signaling favors generation of memory CD8 T cells.","volume":"184","author":"Zhao","year":"2010","journal-title":"J. Immunol."},{"key":"2026012806280824400_r33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1084\/jem.185.2.189","article-title":"The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis.","volume":"185","author":"Nakajima","year":"1997","journal-title":"J. Exp. Med."},{"key":"2026012806280824400_r34","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.4049\/jimmunol.177.7.4521","article-title":"Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection.","volume":"177","author":"Brown","year":"2006","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/10\/5604\/62719596\/ji_1000109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/184\/10\/5604\/62719596\/ji_1000109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:30:23Z","timestamp":1769599823000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/184\/10\/5604\/8006835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2010,5,15]]},"published-print":{"date-parts":[[2010,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1000109","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,5]]},"published":{"date-parts":[[2010,5]]}}}