{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:36:17Z","timestamp":1791329777672,"version":"4.3.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Active T cells release bioactive exosomes (EXOs). However, its potential modulation in immune responses is elusive. In this study, we in vitro generated active OVA-specific CD8+ T cells by cultivation of OVA-pulsed dendritic cells (DCOVA) with naive CD8+ T cells derived from OVA-specific TCR transgenic OTI mice and purified EXOs from CD8+ T cell culture supernatant by differential ultracentrifugation. We then investigated the suppressive effect of T cell EXOs on DCOVA-mediated CD8+ CTL responses and antitumor immunity. We found that DCOVA uptake OTI T cell EXOs expressing OVA-specific TCRs and Fas ligand via peptide\/MHC Ag I\u2013TCR and CD54\u2013LFA-1 interactions leading to downregulation of peptide\/MHC Ag I expression and induction of apoptosis of DCOVA via Fas\/Fas ligand pathway. We demonstrated that OVA-specific OTI T cell EXOs, but not lymphocytic choriomeningitis virus-specific TCR transgenic mouse CD8+ T cell EXOs, can inhibit DCOVA-stimulated CD8+ CTL responses and antitumor immunity against OVA-expressing B16 melanoma. In addition, these T cell EXOs can also inhibit DCOVA-mediated CD8+ CTL-induced diabetes in transgenic rat insulin promoter-mOVA mice. Interestingly, the anti\u2013LFA-1 Ab treatment significantly reduces T cell EXO-induced inhibition of CD8+ CTL responses in both antitumor immunity and autoimmunity. EXOs released from T cell hybridoma RF3370 cells expressing OTI CD8+ TCRs have a similar inhibitory effect as T cell EXOs in DCOVA-stimulated CTL responses and antitumor immunity. Therefore, our data indicate that Ag-specific CD8+ T cells can modulate immune responses via T cell-released EXOs, and T cell EXOs may be useful for treatment of autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1000386","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T03:40:16Z","timestamp":1285818016000},"page":"5268-5278","source":"Crossref","is-referenced-by-count":118,"title":["Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide\/MHC Class I and Fas Ligand-Mediated Cytotoxicity"],"prefix":"10.1093","volume":"185","author":[{"given":"Yufeng","family":"Xie","sequence":"first","affiliation":[{"name":"Research Unit, Division of Health Research, Saskatchewan Cancer Agency, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Oncology, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Immunology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Unit, Division of Health Research, Saskatchewan Cancer Agency, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Oncology, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Immunology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Research Unit, Division of Health Research, Saskatchewan Cancer Agency, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Oncology, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Immunology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Deng","sequence":"additional","affiliation":[{"name":"Research Unit, Division of Health Research, Saskatchewan Cancer Agency, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Oncology, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Immunology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunatha Ankathatti","family":"Munegowda","sequence":"additional","affiliation":[{"name":"Research Unit, Division of Health Research, Saskatchewan Cancer Agency, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Oncology, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Immunology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Chibbar","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabood","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Xiang","sequence":"additional","affiliation":[{"name":"Research Unit, Division of Health Research, Saskatchewan Cancer Agency, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Oncology, University of Saskatchewan , Saskatoon ,","place":["Canada"]},{"name":"Department of Immunology, University of Saskatchewan , Saskatoon ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"2025032412054917900_r1","first-page":"601","article-title":"Advances in dendritic cell-based vaccine of cancer","volume":"17","author":"Zhang","year":"2002","journal-title":"Cancer Biother. 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