{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:03:02Z","timestamp":1790326982105,"version":"4.1.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Monocytes perform diverse roles during infection with the facultative intracellular bacterium Listeria monocytogenes. They are essential as bactericidal cells in host defense but can also become Trojan horses transporting bacteria into the brain. To explain these contrasting roles, we characterized bone marrow (BM) monocytes in steady state and generated during lethal and sublethal L. \u00a0monocytogenes infection. Ly-6ChighCD11b+ BM monocytes expressed high amounts of M-CSFR\/CD115 in steady state and 72 h following sublethal infection. However, infection with increasing numbers of bacteria resulted in progressive loss of CD115 and strongly decreased CD115-encoding c-fms mRNA expression. Conversely, analysis of regulatory molecules showed de novo expression of the nonsignaling IL-1RII, CD121b, under the same conditions. Ly-6ChighCD11b+ monocytes in circulation also acquired a CD115neg\/lowCD121bhigh phenotype during lethal infection. These BM monocytes showed upregulation of suppressor of cytokine signaling 1 and 3 and IL-1R\u2013\"associated kinase-M to a greater extent and\/or earlier compared with cells from sublethal infection and showed decreased LPS-induced IL-6 production despite similar levels of surface TLR4 expression. BM monocytes from uninfected or sublethally infected mice bound and internalized very few L. monocytogenes in vitro. However, both functions were significantly increased in monocytes developing during lethal infection. Nonetheless, these cells did not produce reactive oxygen intermediates, suggesting an inability to kill L. monocytogenes. Together, these data show that systemic infections with lethal and sublethal amounts of bacteria differentially shape developing BM monocytes. This results in distinct phenotypic and functional properties consistent with being Trojan horses rather than bactericidal effector cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1000486","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T16:02:01Z","timestamp":1279123321000},"page":"2432-2441","source":"Crossref","is-referenced-by-count":28,"title":["Severe\n                    <i>Listeria monocytogenes<\/i>\n                    Infection Induces Development of Monocytes with Distinct Phenotypic and Functional Features"],"prefix":"10.1093","volume":"185","author":[{"given":"Douglas A","family":"Drevets","sequence":"first","affiliation":[{"name":"Department of Medicine, Oklahoma University Health Sciences Center , Oklahoma City, OK 73014"},{"name":"Veterans Affairs Medical Center , Oklahoma City, OK 73014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E","family":"Schawang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Oklahoma University Health Sciences Center , Oklahoma City, OK 73014"},{"name":"Veterans Affairs Medical Center , Oklahoma City, OK 73014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay K","family":"Mandava","sequence":"additional","affiliation":[{"name":"Department of Medicine, Oklahoma University Health Sciences Center , Oklahoma City, OK 73014"},{"name":"Veterans Affairs Medical Center , Oklahoma City, OK 73014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn J","family":"Dillon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Oklahoma University Health Sciences Center , Oklahoma City, OK 73014"},{"name":"Veterans Affairs Medical Center , Oklahoma City, OK 73014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J M","family":"Leenen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus University Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,15]]},"reference":[{"key":"2025032411484763300_r1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nri1630","article-title":"Negative regulation of toll-like receptor-mediated immune responses","volume":"5","author":"Liew","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411484763300_r2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"2025032411484763300_r3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1128\/CMR.17.2.323-347.2004","article-title":"Invasion of the central nervous system by intracellular bacteria","volume":"17","author":"Drevets","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"2025032411484763300_r4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-065X.1997.tb00993.x","article-title":"Some macrophages kill Listeria monocytogenes while others do not","volume":"158","author":"Fleming","year":"1997","journal-title":"Immunol. Rev."},{"key":"2025032411484763300_r5","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.4049\/jimmunol.172.7.4418","article-title":"The Ly-6Chigh monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice","volume":"172","author":"Drevets","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411484763300_r6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1462-5822.2004.00444.x","article-title":"Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system","volume":"7","author":"Join-Lambert","year":"2005","journal-title":"Cell. Microbiol."},{"key":"2025032411484763300_r7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1084\/jem.170.1.27","article-title":"Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells. Absence of monocytes at infective foci allows Listeria to multiply in nonphagocytic cells","volume":"170","author":"Rosen","year":"1989","journal-title":"J. Exp. Med."},{"key":"2025032411484763300_r8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"2025032411484763300_r9","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.4049\/jimmunol.172.7.4410","article-title":"Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response","volume":"172","author":"Sunderk\u00f6tter","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411484763300_r10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0022-1759(98)00080-5","article-title":"Bone marrow cellular composition in Listeria monocytogenes infected mice detected using ER-MP12 and ER-MP20 antibodies: a flow cytometric alternative to differential counting","volume":"217","author":"de Bruijn","year":"1998","journal-title":"J. Immunol. Methods"},{"key":"2025032411484763300_r11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1574-695X.2008.00404.x","article-title":"Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion","volume":"53","author":"Drevets","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2025032411484763300_r12","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1128\/IAI.69.3.1344-1350.2001","article-title":"Listeria monocytogenes-infected phagocytes can initiate central nervous system infection in mice","volume":"69","author":"Drevets","year":"2001","journal-title":"Infect. Immun."},{"key":"2025032411484763300_r13","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.4049\/jimmunol.153.11.5141","article-title":"TNF-alpha and IFN-gamma stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner","volume":"153","author":"Leenen","year":"1994","journal-title":"J. Immunol."},{"key":"2025032411484763300_r14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/eji.1830200105","article-title":"Murine macrophage precursor characterization. II. Monoclonal antibodies against macrophage precursor antigens","volume":"20","author":"Leenen","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"2025032411484763300_r15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0022-1759(90)90198-5","article-title":"A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123","volume":"131","author":"Emmend\u00f6rffer","year":"1990","journal-title":"J. Immunol. Methods"},{"key":"2025032411484763300_r16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.humimm.2009.06.017","article-title":"Comparison of degranulation of easily mobilizable intracellular granules by human phagocytes in healthy subjects and patients with infectious diseases","volume":"70","author":"Nuutila","year":"2009","journal-title":"Hum. Immunol."},{"key":"2025032411484763300_r17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/cimm.1996.0167","article-title":"Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium","volume":"171","author":"Kannan","year":"1996","journal-title":"Cell. Immunol."},{"key":"2025032411484763300_r18","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.4049\/jimmunol.166.3.1583","article-title":"TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation","volume":"166","author":"Rovida","year":"2001","journal-title":"J. Immunol."},{"key":"2025032411484763300_r19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.immunol.22.091003.090312","article-title":"The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response","volume":"22","author":"Alexander","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"2025032411484763300_r20","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1086\/651134","article-title":"Synthetic human chorionic gonadotropin-related oligopeptides impair early innate immune responses to Listeria monocytogenes in Mice","volume":"201","author":"van der Zee","year":"2010","journal-title":"J. Infect. Dis."},{"key":"2025032411484763300_r21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/CVI.13.1.156-159.2006","article-title":"Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2","volume":"13","author":"Heesen","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"2025032411484763300_r22","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.4049\/jimmunol.180.9.6421","article-title":"Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression","volume":"180","author":"Pachot","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411484763300_r23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0022-1759(91)90289-R","article-title":"Macrophage phagocytosis: use of fluorescence microscopy to distinguish between extracellular and intracellular bacteria","volume":"142","author":"Drevets","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"2025032411484763300_r24","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.4049\/jimmunol.171.10.5447","article-title":"Localized reactive oxygen and nitrogen intermediates inhibit escape of Listeria monocytogenes from vacuoles in activated macrophages","volume":"171","author":"Myers","year":"2003","journal-title":"J. Immunol."},{"key":"2025032411484763300_r25","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.4049\/jimmunol.169.7.3869","article-title":"MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity","volume":"169","author":"Edelson","year":"2002","journal-title":"J. Immunol."},{"key":"2025032411484763300_r26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1189\/jlb.0905529","article-title":"Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages","volume":"81","author":"Vila-del Sol","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"2025032411484763300_r27","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ni.1671","article-title":"Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens","volume":"9","author":"El Kasmi","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025032411484763300_r28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.it.2009.07.009","article-title":"Endotoxin tolerance: new mechanisms, molecules and clinical significance","volume":"30","author":"Biswas","year":"2009","journal-title":"Trends Immunol."},{"key":"2025032411484763300_r29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1203\/PDR.0b013e3181559774","article-title":"Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome","volume":"62","author":"Hall","year":"2007","journal-title":"Pediatr. Res."},{"key":"2025032411484763300_r30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/CCM.0b013e318194b1bf","article-title":"Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis)","volume":"37","author":"Wiersinga","year":"2009","journal-title":"Crit. Care Med."},{"key":"2025032411484763300_r31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/cimm.2000.1749","article-title":"Relationships between IFNgamma, IL-6, corticosterone, and Listeria monocytogenes pathogenesis in BALB\/c mice","volume":"207","author":"Kim","year":"2001","journal-title":"Cell. Immunol."},{"key":"2025032411484763300_r32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4049\/jimmunol.181.1.529","article-title":"Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain","volume":"181","author":"Drevets","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411484763300_r33","doi-asserted-by":"crossref","first-page":"e1000355","DOI":"10.1371\/journal.ppat.1000355","article-title":"Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes","volume":"5","author":"Stockinger","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025032411484763300_r34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1600-065X.2008.00659.x","article-title":"Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins","volume":"224","author":"Dimitriou","year":"2008","journal-title":"Immunol. Rev."},{"key":"2025032411484763300_r35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00062752-200701000-00004","article-title":"The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways","volume":"14","author":"Wormald","year":"2007","journal-title":"Curr. Opin. Hematol."},{"key":"2025032411484763300_r36","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.178.4.2407","article-title":"Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive mice","volume":"178","author":"Humann","year":"2007","journal-title":"J. Immunol."},{"key":"2025032411484763300_r37","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.166.1.466","article-title":"Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3","volume":"166","author":"Stoiber","year":"2001","journal-title":"J. Immunol."},{"key":"2025032411484763300_r38","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.4049\/jimmunol.156.7.2534","article-title":"Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes","volume":"156","author":"Colotta","year":"1996","journal-title":"J. Immunol."},{"key":"2025032411484763300_r39","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1182\/blood-2006-02-001115","article-title":"Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes","volume":"109","author":"Ehrchen","year":"2007","journal-title":"Blood"},{"key":"2025032411484763300_r40","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1128\/iai.64.9.3475-3483.1996","article-title":"Differential regulation of cytokine and cytokine receptor mRNA expression upon infection of bone marrow-derived macrophages with Listeria monocytogenes","volume":"64","author":"Demuth","year":"1996","journal-title":"Infect. Immun."},{"key":"2025032411484763300_r41","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1182\/blood-2002-03-0898","article-title":"Interaction of human hematopoietic stem cells with bacterial pathogens","volume":"100","author":"Kolb-M\u00e4urer","year":"2002","journal-title":"Blood"},{"key":"2025032411484763300_r42","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.niox.2004.04.007","article-title":"Nitric oxide activates the expression of IRAK-M via the release of TNF-alpha in human monocytes","volume":"10","author":"del Fresno","year":"2004","journal-title":"Nitric Oxide"},{"key":"2025032411484763300_r43","doi-asserted-by":"crossref","first-page":"15258","DOI":"10.1074\/jbc.M709549200","article-title":"CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases","volume":"283","author":"Kim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025032411484763300_r44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0092-8674(02)00827-9","article-title":"IRAK-M is a negative regulator of Toll-like receptor signaling","volume":"110","author":"Kobayashi","year":"2002","journal-title":"Cell"},{"key":"2025032411484763300_r45","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1074\/jbc.M308620200","article-title":"Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages","volume":"279","author":"Nakayama","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2025032411484763300_r46","first-page":"2532","article-title":"Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M","volume":"116","author":"Deng","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2025032411484763300_r47","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.8332913","article-title":"Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4","volume":"261","author":"Colotta","year":"1993","journal-title":"Science"},{"key":"2025032411484763300_r48","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.4049\/jimmunol.148.5.1486","article-title":"Type I IL-1 receptor blockade exacerbates murine listeriosis","volume":"148","author":"Havell","year":"1992","journal-title":"J. Immunol."},{"key":"2025032411484763300_r49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4049\/jimmunol.169.1.393","article-title":"The epistatic interrelationships of IL-1, IL-1 receptor antagonist, and the type I IL-1 receptor","volume":"169","author":"Irikura","year":"2002","journal-title":"J. Immunol."},{"key":"2025032411484763300_r50","doi-asserted-by":"crossref","first-page":"978","DOI":"10.4049\/jimmunol.163.2.978","article-title":"Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase","volume":"163","author":"Thomas","year":"1999","journal-title":"J. Immunol."},{"key":"2025032411484763300_r51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.imbio.2007.10.008","article-title":"Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins","volume":"213","author":"Dalpke","year":"2008","journal-title":"Immunobiology"},{"key":"2025032411484763300_r52","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1242\/jcs.112.18.2993","article-title":"Leishmania species: models of intracellular parasitism","volume":"112","author":"Alexander","year":"1999","journal-title":"J. Cell Sci."},{"key":"2025032411484763300_r53","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1189\/jlb.0306206","article-title":"Mycobacterium avium-induced SOCS contributes to resistance to IFN-gamma-mediated mycobactericidal activity in human macrophages","volume":"80","author":"V\u00e1zquez","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2025032411484763300_r54","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.4049\/jimmunol.176.3.1840","article-title":"Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling","volume":"176","author":"Zimmermann","year":"2006","journal-title":"J. Immunol."},{"key":"2025032411484763300_r55","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.4049\/jimmunol.180.9.6270","article-title":"Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo","volume":"180","author":"Liu","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411484763300_r56","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.4049\/jimmunol.149.8.2656","article-title":"IFN-gamma\/lipopolysaccharide activation of macrophages is associated with protein kinase C-dependent down-modulation of the colony-stimulating factor-1 receptor","volume":"149","author":"Baccarini","year":"1992","journal-title":"J. Immunol."},{"key":"2025032411484763300_r57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1242\/jcs.70.1.147","article-title":"Receptor-mediated binding and internalization of colony-stimulating factor (CSF-1) by mouse peritoneal exudate macrophages","volume":"70","author":"Chen","year":"1984","journal-title":"J. Cell Sci."},{"key":"2025032411484763300_r58","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.4049\/jimmunol.163.12.6541","article-title":"Bacterial\/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival","volume":"163","author":"Sester","year":"1999","journal-title":"J. Immunol."},{"key":"2025032411484763300_r59","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.4049\/jimmunol.143.8.2534","article-title":"Modulation of colony-stimulating factor-1 receptors on macrophages by tumor necrosis factor","volume":"143","author":"Shieh","year":"1989","journal-title":"J. Immunol."},{"key":"2025032411484763300_r60","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.4049\/jimmunol.173.9.5343","article-title":"Mechanisms of soluble cytokine receptor generation","volume":"173","author":"Levine","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411484763300_r61","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2741\/2700","article-title":"The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis","volume":"13","author":"Bonifer","year":"2008","journal-title":"Front. Biosci."},{"key":"2025032411484763300_r62","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0092-8674(90)90510-L","article-title":"Expression of the M-CSF receptor is controlled posttranscriptionally by the dominant actions of GM-CSF or multi-CSF","volume":"63","author":"Gliniak","year":"1990","journal-title":"Cell"},{"key":"2025032411484763300_r63","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1242\/jcs.109.7.1795","article-title":"IL-3, GM-CSF and CSF-1 modulate c-fms mRNA more rapidly in human early monocytic progenitors than in mature or transformed monocytic cells","volume":"109","author":"Panterne","year":"1996","journal-title":"J. Cell Sci."},{"key":"2025032411484763300_r64","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.20072108","article-title":"Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder","volume":"205","author":"O\u2019Connell","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025032411484763300_r65","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.4049\/jimmunol.0900612","article-title":"Selective expansion of the monocytic lineage directed by bacterial infection","volume":"183","author":"Serbina","year":"2009","journal-title":"J. Immunol."},{"key":"2025032411484763300_r66","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1182\/blood.V91.3.863","article-title":"Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice","volume":"91","author":"Zhan","year":"1998","journal-title":"Blood"},{"key":"2025032411484763300_r67","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","article-title":"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization","volume":"84","author":"Lieschke","year":"1994","journal-title":"Blood"},{"key":"2025032411484763300_r68","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1182\/blood-2007-03-079178","article-title":"The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo","volume":"110","author":"Boyle","year":"2007","journal-title":"Blood"},{"key":"2025032411484763300_r69","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1128\/iai.56.1.247-251.1988","article-title":"Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs","volume":"56","author":"Cheers","year":"1988","journal-title":"Infect. Immun."},{"key":"2025032411484763300_r70","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1128\/iai.45.1.180-184.1984","article-title":"Changes in serum colony-stimulating factor and monocytic progenitor cells during Listeria monocytogenes infection in mice","volume":"45","author":"Wing","year":"1984","journal-title":"Infect. Immun."},{"key":"2025032411484763300_r71","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0165-2478(91)90158-7","article-title":"Identification of cytokines which enhance (CSF-1, IL-3) or restrict (IFN-gamma) growth of intramacrophage Listeria monocytogenes","volume":"27","author":"Denis","year":"1991","journal-title":"Immunol. Lett."},{"key":"2025032411484763300_r72","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/jlb.66.6.961","article-title":"Surface interleukin-10 inhibits listericidal activity by primary macrophages","volume":"66","author":"Fleming","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"2025032411484763300_r73","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jlb.51.1.69","article-title":"Differential immunocompetence of macrophages derived using macrophage or granulocyte-macrophage colony-stimulating factor","volume":"51","author":"Rutherford","year":"1992","journal-title":"J. Leukoc. Biol."},{"key":"2025032411484763300_r74","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.4049\/jimmunol.178.8.5245","article-title":"Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation","volume":"178","author":"Fleetwood","year":"2007","journal-title":"J. Immunol."},{"key":"2025032411484763300_r75","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nm0503-517","article-title":"Novel strategies for the treatment of sepsis","volume":"9","author":"Riedemann","year":"2003","journal-title":"Nat. Med."},{"key":"2025032411484763300_r76","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm0697-678","article-title":"Monocyte deactivation in septic patients: restoration by IFN-gamma treatment","volume":"3","author":"D\u00f6cke","year":"1997","journal-title":"Nat. Med."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/4\/2432\/61610989\/1000486.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/4\/2432\/61610989\/1000486.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T19:22:20Z","timestamp":1743189740000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/185\/4\/2432\/7977699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1000486","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,8]]},"published":{"date-parts":[[2010,8]]}}}